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Traditional Chinese medicine composition for treating intrahepatic cholestasis in gestation period and preparation method thereof

A technology of cholestasis and composition, which is applied in the field of traditional Chinese medicine composition for the treatment of intrahepatic cholestasis of pregnancy and its preparation, can solve the problems of poor therapeutic effect and slow curative effect, and achieve improved therapeutic effect, accelerated fat metabolism, The effect of enhancing the potency

Inactive Publication Date: 2022-01-04
浙江养和健康管理科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Existing drugs have slow curative effect and poor therapeutic effect

Method used

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  • Traditional Chinese medicine composition for treating intrahepatic cholestasis in gestation period and preparation method thereof

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preparation example Construction

[0033] A preparation method of a traditional Chinese medicine composition for treating intrahepatic cholestasis of pregnancy, comprising the following steps:

[0034] Add water to decoct evening primrose, ginkgo biloba, Osmanthus osmanthus at 70-90°C for 1-2h, filter the dregs and add water to decoct at 50-60°C for 0.5-1h, combine the two decoctions to obtain the extract; Poria cocos, Atractylodes macrocephala, Polygonum multiflorum, walnut kernel, psoraleae, and salvia miltiorrhiza are ultrafinely pulverized by airflow, passed through a 40-70 mesh sieve, and chloroform is added to the powder for ultrasonic extraction for 30-50 minutes. The quality of chloroform is 2-7 times that of the raw material. The extract is obtained by filtration, and the extract is separated by chromatography to obtain a chromatographic liquid; the extract and the chromatographic liquid are mixed, and centrifuged at 200-300 r / min for 10-20 min to obtain a medicinal liquid.

[0035] In this embodiment,...

Embodiment 1

[0042] A traditional Chinese medicine composition for treating intrahepatic cholestasis of pregnancy, comprising the following raw materials:

[0043] 5g evening primrose, 8g Poria cocos, 3g Atractylodes macrocephala, 10g Polygonum multiflorum, 1g ginkgo leaf, 2g walnut kernel, 4g Osmanthus chinensis, 5g psoraleae and 6g salvia miltiorrhiza.

[0044] A preparation method of a traditional Chinese medicine composition for treating intrahepatic cholestasis of pregnancy, comprising the following steps:

[0045] Add water to decoct evening primrose, ginkgo leaves, and Osmanthus osmanthus at 70°C for 1 hour, filter and add water to decoct the medicinal residues at 50°C for 0.5 hour, combine the two decoctions to obtain the extract; Ren, psoraleae, and salvia are ultrafinely pulverized by airflow, passed through a 40-mesh sieve, added chloroform to the drug powder and extracted ultrasonically for 30 minutes. The quality of chloroform is twice that of the raw material, and the extract...

Embodiment 2

[0047] A traditional Chinese medicine composition for treating intrahepatic cholestasis of pregnancy, comprising the following raw materials:

[0048] 9g evening primrose, 17g Poria cocos, 10g Atractylodes macrocephala, 20g Polygonum multiflorum, 6g ginkgo leaves, 7g walnut kernels, 12g Osmanthus chinensis, 11g psoraleae and 15g salvia miltiorrhiza.

[0049] A preparation method of a traditional Chinese medicine composition for treating intrahepatic cholestasis of pregnancy, comprising the following steps:

[0050] Add water to decoct evening primrose, ginkgo leaves, Osmanthus osmanthus at 90°C for 2 hours, filter the dregs and add water to decoct at 60°C for 1 hour, combine the two decoctions to obtain the extract; , Psoraleae, and Salvia miltiorrhiza were ultrafinely pulverized by airflow, passed through a 70-mesh sieve, added chloroform to the powder for ultrasonic extraction for 50 minutes, the quality of chloroform was 7 times that of the raw material, filtered to obtain ...

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Abstract

The invention provides a traditional Chinese medicine composition for treating intrahepatic cholestasis in a gestation period and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine composition is prepared from the following raw materials of evening primrose, poria cocos, bighead atractylodes rhizome, radix polygoni multiflori, ginkgo leaves, walnut kernels, rhizoma osmundae, fructus psoraleae and salvia miltiorrhiza. The traditional Chinese medicine composition can quickly promote biliary secretion and discharge, reduce the content of estrogen, remarkably reduce the content of cholic acid and reduce cholesterol, and achieves the effect of protecting the liver, so that intrahepatic cholestasis in the gestation period is treated. In the preparation method, the effective components of the medicinal materials are extracted by using different methods, so that the effective components in the different medicinal materials can be fully extracted, the content of the effective components in the extract is increased, and the medicine has a better treatment effect and a faster curative effect on the intrahepatic stasis disease in the gestation period.

Description

technical field [0001] The invention relates to the technical field of preparation of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating intrahepatic cholestasis of pregnancy and a preparation method thereof. Background technique [0002] Intrahepatic cholestasis of pregnancy (ICP) is a unique complication in the second and third trimesters of pregnancy. Clinically, it is characterized by skin itching and elevated bile acids. It mainly harms the fetus and increases perinatal morbidity and mortality. The main cause of the disease is that the level of estrogen in pregnant women increases significantly, and estrogen can make Na + -K + - ATPase activity decreases, energy supply decreases, leading to bile acid metabolism disorder; estrogen can increase the ratio of cholesterol to phospholipids in the liver cell membrane, reduce fluidity, affect the permeability of bile acid, and block the outflow of bile; estrogen effect Estr...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61P15/00A61P1/16A23L33/10A23L31/00A61K31/353
CPCA61K36/185A61K36/076A61K36/284A61K36/704A61K36/16A61K36/52A61K36/12A61K36/487A61K36/537A61K36/54A61K36/282A61K36/28A61K31/353A61K36/82A61P15/00A61P1/16A23L33/10A23L31/00A61K2236/331A61K2236/39A61K2236/35A23V2002/00A61K2300/00A23V2200/324
Inventor 吕向东
Owner 浙江养和健康管理科技有限公司
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