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A kind of oral preparation for lowering uric acid and preparation method thereof

An oral preparation, a technology for lowering uric acid, which is applied in the directions of antitoxins, pharmaceutical formulations, and medical preparations containing active ingredients, etc. the effect of

Active Publication Date: 2022-05-31
河北一然生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above-mentioned shortcomings and deficiencies of the prior art, the present invention provides a uric acid-lowering oral preparation and a preparation method thereof. By designing a formula of a Chinese medicine composition, screening specific probiotics, and fermenting the Chinese medicine composition to produce a fermented liquid, the The fermented liquid is further made into uric acid-lowering oral liquid or concentrated and added with excipients to make oral medicaments. It has been proved by taking experiments that it can significantly reduce uric acid in human blood, which solves the side effects caused by traditional western medicine and traditional Chinese medicine soup. Traditional Chinese medicines and Chinese patent medicines have slow onset and insignificant effects, etc.

Method used

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  • A kind of oral preparation for lowering uric acid and preparation method thereof
  • A kind of oral preparation for lowering uric acid and preparation method thereof
  • A kind of oral preparation for lowering uric acid and preparation method thereof

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Effect test

Embodiment 1

[0058] The present embodiment provides a preparation method of a uric acid-lowering oral liquid, and the specific method is as follows:

[0059] Step 1: Activation of Lactobacillus plantarum LP45 strain

[0060] Lactobacillus plantarum LP45, which was frozen at -80 °C, was inserted into MRS liquid medium, cultivated at 37 °C for 18 h, and after continuous activation for three generations, centrifuged at 6000 rpm for 10 min at 4 °C, discarded the supernatant, and sterilized the bacteria. After washing three times with normal saline, resuspend in normal saline and adjust the cell concentration to 1 × 10 9 CFU / mL is the cell suspension, which is stored at a low temperature of 4°C until use.

[0061] Step 2: Preparation of uric acid-lowering oral solution

[0062] (1) Weigh 18 parts by mass of Angelica sinensis, 19 parts by mass of Codonopsis pilosula, 15 parts by mass of Poria cocos, 20 parts by mass of Chuanxiong, 16 parts by mass of licorice, 25 parts by mass of Tianzhu Huang...

Embodiment 2

[0066] The present embodiment provides a preparation method of a uric acid-lowering oral liquid, and the specific method is as follows:

[0067] Step 1: Activate the Lactobacillus plantarum LP45 strain according to the method of Example 1

[0068] Step 2: Preparation of uric acid-lowering oral solution

[0069] (1) Weigh 18 parts by mass of Angelica sinensis, 9 parts by mass of Codonopsis pilosula, 20 parts by mass of Poria cocos, 20 parts by mass of Chuanxiong, 16 parts by mass of licorice, 20 parts by mass of Tianzhu Huang, 25 parts by mass of raw land, 25 parts by mass of Parts of white peony root, 22 parts by mass of dried tangerine peel, 25 parts by mass of Fried Chicken Neijin, 30 parts by mass of Jiaoshan Hawthorn and 16 parts by mass of Curcuma Radix are removed and ground to obtain traditional Chinese medicine powder.

[0070] (2) Add 15 times pure water according to the quality of the traditional Chinese medicine powder, sterilize in an autoclave at 115° C. for 20 m...

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Abstract

The present invention relates to a preparation method of an oral preparation for lowering uric acid, which comprises: S1, compatibility of traditional Chinese medicine composition, including: angelica, codonopsis, poria cocos, chuanxiong, licorice, tianzhuhuang, raw land, white peony root, tangerine peel, fried gallinaceous gold, Jiao hawthorn and turmeric; S2. Fermentation to obtain traditional Chinese medicine fermentation liquid: grind the traditional Chinese medicine composition to obtain traditional Chinese medicine powder, add water, sterilize it as a fermentation substrate, inoculate Lactobacillus plantarum LP45 for fermentation, and produce a traditional Chinese medicine fermentation liquid. Further make oral preparations for lowering uric acid. The traditional Chinese medicine fermentation liquid prepared by the present invention can inhibit the oxidative stress of the body caused by the increase of uric acid, effectively remove free radicals such as hydroxyl radicals, DPPH, superoxide anion, and ABTS, and achieve anti-oxidation and reduce uric acid production by removing free radicals Oxidative stress in the body during the process, thereby reducing or inhibiting the occurrence of inflammation. The traditional Chinese medicine fermentation liquid can also significantly inhibit the activity of xanthine oxidase, which is beneficial to reducing the production of uric acid in patients and treating gout.

Description

technical field [0001] The invention relates to the technical field of functional foods, in particular to a probiotic traditional Chinese medicine fermented liquid uric acid-lowering oral preparation and a preparation method thereof. Background technique [0002] Hyperuricemia refers to the abnormal increase of serum uric acid concentration caused by the disorder of purine metabolism or the intake of excessive purine foods. There are generally three reasons for high uric acid: First, a large amount of food containing high purines is consumed in the usual diet, and these foreign purines are metabolized to produce uric acid into the blood; catabolism to form uric acid; third, the decline in renal function that is, the ability to excrete uric acid is reduced. Long-term hyperuricemia can lead to serious diseases such as gout, kidney stones, renal insufficiency, impaired liver function, arteriosclerosis, and high blood pressure. [0003] The acute attack of gout is that the cry...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P19/06A61P39/06A23L33/105A61K35/57
CPCA61K36/232A61K36/344A61K36/076A61K36/236A61K36/484A61K36/899A61K36/804A61K36/71A61K36/65A61K36/752A61K35/57A61K36/734A61K36/9066A61P19/06A61P39/06A23L33/105A61K2236/19A23V2002/00A61K2300/00A23V2200/30Y02P60/87
Inventor 赵星严超范会芬王建云马若琰李水玲王岩赵林森
Owner 河北一然生物科技股份有限公司