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Water-soluble fullerene compound as well as preparation method and application thereof

A fullerene complex, water-soluble technology, applied in the direction of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve problems such as difficult to achieve industrialization goals, complicated process, and affect the use effect, and achieve good water solubility Sexuality, simple preparation process, and the effect of repairing the skin barrier

Pending Publication Date: 2022-01-07
苏州仁生泽发生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many defects in the prior art, including complex technological process, high industrialization cost, no large-scale production, and it is difficult to achieve the purpose of industrialization; a large amount of organic reagents are used, resulting in solvent residue; the suspension of fullerenes does not fully absorb the fullerenes. Dispersed or dissolved state; the compounding of fullerene with polymer materials or compositions may affect the effect of later use, making it difficult to be absorbed by the skin

Method used

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  • Water-soluble fullerene compound as well as preparation method and application thereof
  • Water-soluble fullerene compound as well as preparation method and application thereof
  • Water-soluble fullerene compound as well as preparation method and application thereof

Examples

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preparation example Construction

[0073] Another aspect of the present disclosure relates to a method for preparing a water-soluble fullerene complex, the preparation method comprising:

[0074] Take fullerene powder and mix evenly with water-soluble raw materials, wherein the weight ratio of fullerene to water-soluble raw materials is 1:10–1:200;

[0075] The fullerene powder and the water-soluble raw material mixture are subjected to intensive dispersion treatment to obtain a mixture powder material; the obtained powder material is fully dissolved in water, and after high-speed centrifugation in a centrifugal device, a supernatant is obtained; Concentrate and dry to obtain the water-soluble fullerene complex.

[0076] In one embodiment, the preparation method of the water-soluble fullerene complex, wherein the weight percentage of the fullerene and the water-soluble raw material is 1:2-1:200, preferably 1:10-1:100, or 1:20-1:100, or 1:20-1:50, or 1:30-1:50, or 1:50-1:100.

[0077] In one embodiment, the pr...

Embodiment 1

[0119] Example 1: Preparation and Water Solubility Test of Fullerene Tremella Polysaccharide Complex

[0120] Weigh 1g of fullerene C60 and 60g of tremella polysaccharide, add them to the mixing tank, the equipment acceleration is 10g, run for 7h, sample 0.2g every 1h, add 50ml of water to dissolve, use a desktop centrifuge for centrifugation, and take the supernatant for Filter with a 0.45um syringe filter to obtain a fullerene tremella polysaccharide solution for ultraviolet detection. The experimental results are shown in Table 1.

[0121] The results showed that: under the same feed ratio, the treatment time was 1-7h, and the fullerene tremella polysaccharide complex with good water solubility could be obtained. With the increase of treatment time, the value of ultraviolet detection absorbance A gradually increased, indicating that the fullerene content in the water-soluble composition gradually increased, and the recombination rate gradually increased, but when the treat...

Embodiment 2

[0130] Example 2: Preparation and water solubility test of fullerene ectoine complex

[0131] Weigh 1g of fullerene C60 and 50g of ectoine, add them to the mixing tank, the equipment acceleration is 10g, run for 7h, take 0.5g of samples every 1h, add 50ml of water to dissolve, use a desktop centrifuge for centrifugation, and take the supernatant The solution was filtered through a 0.45um syringe filter to obtain a fullerene ectoine solution for ultraviolet detection. The experimental results are shown in Table 3.

[0132] The results show that: under the same feed ratio, the treatment time is 1-5h, and the fullerene ectoine complex with good water solubility can be obtained. With the increase of treatment time, the value of ultraviolet detection absorbance A gradually increased, indicating that the fullerene content in the fullerene ectoin water-soluble composition gradually increased, and the recombination rate gradually increased, and the fullerene content was the highest a...

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Abstract

The invention relates to a water-soluble fullerene polymer compound as well as a preparation method and application thereof. The fullerene compound disclosed by the invention has good water solubility, and can be more easily added into cosmetics to accelerate skin absorption, so that the effects of scavenging free radicals, whitening, moisturizing and the like are achieved.

Description

technical field [0001] The disclosure relates to the field of polymer materials, in particular to a water-soluble fullerene compound and its preparation method and application. Background technique [0002] In 1985, scientists Kroto, Smalley, Curl and others discovered C60 fullerene when studying carbon elements in deep space. In 1996, they won the Nobel Prize in Chemistry for this. Fullerene, diamond and graphite are allotropes of carbon. C60 is a spherical molecule composed of 60 carbon atoms. It consists of 12 pentagons and 20 hexagons. Each carbon atom and the adjacent three carbon atoms form bonds through SP2 hybridization. It is called football because of its shape. For football ene. [0003] The large π-bonded conjugated system composed of multiple P orbitals of fullerene makes it have a strong ability to accept electrons. Because of its unique structure and physical and chemical properties, it has excellent free radical scavenging performance, known as The "free r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/19A61K8/49A61K8/60A61K8/65A61K8/68A61K8/73A61K8/88A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/88A61K8/4953A61K8/68A61K8/65A61K8/19A61K8/60A61K8/73A61Q19/02A61Q19/08A61Q19/00A61K2800/522
Inventor 李慧许哲
Owner 苏州仁生泽发生物科技有限公司