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Radioactive lumen stent and preparation method thereof

A radioactive and radionuclide technology, applied in the field of radioactive lumen stents and their preparation, can solve the problems of increased treatment costs and risks, poor radiation dose uniformity, harsh production conditions, etc. The effect of simple production cost and production method

Active Publication Date: 2022-01-11
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005]1. The existing radioactive stent design has only a few radioactive particles attached to the stent, while the stent itself covers a much larger area, which leads to poor Uniformity of radiation dose, resulting in local exposure to excessive radiation dose, while the area with too little radiation dose will still cause the tumor to grow into the stent, which may affect the patient's curative effect;
[0006]2. When the existing radioactive stent is placed, the patient needs to undergo multiple puncture operations, which increases the treatment cost and risk;
[0007]3. The existing radioactive stent design method has harsh production conditions, high production cost and high price

Method used

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  • Radioactive lumen stent and preparation method thereof
  • Radioactive lumen stent and preparation method thereof
  • Radioactive lumen stent and preparation method thereof

Examples

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Embodiment 1

[0056] This example is marked with a polydopamine coating 131 I nuclide radioactive stent (referred to as stent@PDA- 131 I) and its synthetic method are examples.

[0057] The principle of polydopamine labeling iodine: polydopamine coating labeling iodine-131 nuclide radioactive stent, firstly, polydopamine coating self-polymerizes on the surface of bare metal stent, and then uses sodium periodate to further oxidize polydopamine coating for labeling The chemical form of radioactive iodine is Na 131 I, I- must be oxidized to the high-valent oxidation state I 2 or I + In order to label organic compound molecules. Oxidation of Na using chloramine T 131 I, chloramine T (N-chloro p-benzenesulfonamide sodium salt), produces hypochlorous acid in aqueous solution, hypochlorous acid can I - Oxidized to I 2 , I 2 Na 131 After I is reduced by chloramine T into high-priced iodine-131 simple substance, the ortho-carbon of the phenolic hydroxyl group of polydopamine is electrophili...

Embodiment 2

[0072] This embodiment is labeled with polydopamine coating ligand 131 I radioactive stent (referred to as Tyr-stent@PDA- 131 I) and its synthetic method are examples.

[0073] In the Tyr-stent@PDA-131I of this example, the ligand is Tyrosine (Tyrosine), and Tyrosine is first bound to the polydopamine coating on the surface of the stent through Michael addition reaction, 131 The I label is through its electrophilic attack on the ortho-carbon of the phenolic hydroxyl group of tyrosine, so that the 131 I marks on the surface of the stent. Iodine labeling by tyrosine is 131 Conventional method of labeling of I.

[0074] The preparation method comprises the following steps:

[0075] (1) The stent was ultrasonically cleaned in isopropanol and ultrapure water for 10 min each. Weigh 10 mg of dopamine in a glass bottle, add 5 mL of Tris-HCl (pH 8.5) buffer solution into the glass bottle to make a 2 mg / mL dopamine solution, completely immerse the stent in the dopamine solution, a...

Embodiment 3

[0082] In this embodiment, the polydopamine coating has a ligand label 131 I radioactive stent (referred to as Tyr-stent@PDA- 131 I) and its synthetic method are examples.

[0083] In this embodiment Tyr-stent@PDA- 131 In I, the ligand adopts tyrosine (Tyrosine), and tyrosine is first combined on the polydopamine coating on the surface of the stent by Michael addition reaction, at this moment, 131 I electrophilically attacks the ortho-carbon of the phenolic hydroxyl group of tyrosine, thereby 131 I is labeled on the surface of the scaffold, which is a ligand-labeled method for iodine-131.

[0084] The preparation method comprises the following steps:

[0085] (1) The stent was ultrasonically cleaned in isopropanol and ultrapure water for 10 min each. Weigh 10 mg of dopamine in a glass bottle, add 5 mL of Tris-HCl (pH 8.5) buffer solution into the glass bottle to make a 2 mg / mL dopamine solution, completely immerse the stent in the dopamine solution, and react at room temp...

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Abstract

The invention discloses a radioactive lumen stent and a preparation method thereof, and relates to the technical field of medical instruments containing radioactive substances. The radioactive lumen stent comprises a bare stent, a polymer coating and radionuclides, the polymer coating uniformly covers the surface of the bare stent, and the radionuclides are marked on the bare stent through the polymer coating; the preparation method of the radioactive lumen stent comprises a ligand-free labeling preparation method and a ligand labeling preparation method, the ligand-free labeling preparation method comprises the step of directly labeling radionuclides on the surface of a polymer coating stent, and the ligand labeling preparation method comprises the step of labeling the radionuclides on the surface of the polymer coating stent by using ligands. Clinical application of the radioactive stent can be greatly promoted, and the treatment effect of a patient is expected to be improved.

Description

technical field [0001] The invention relates to the technical field of medical devices containing radioactive substances, in particular to a radioactive lumen stent and a preparation method thereof. Background technique [0002] Malignant biliary obstruction refers to the narrowing of the biliary tract that prevents the flow of bile from the liver into the duodenum, resulting in symptoms such as obstructive jaundice, usually caused by pancreatic cancer and cholangiocarcinoma. However, because patients have no obvious symptoms in the early stage, they are usually at an unresectable stage when they are diagnosed, and only 10%-20% of patients can undergo surgery. The 3- and 5-year survival rates after resection remain low at 18-52% and 5-31%, respectively. In unresectable patients, implantation of biliary obstruction stents is considered the preferred modality for relief of pruritus, cholangitis, pain, and jaundice. However, the stents currently used clinically only play a dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/16A61L31/14A61N5/10A61F2/04A61F2/82
CPCA61L31/10A61N5/1014A61N5/1007A61F2/04A61F2/82A61L31/16A61L31/14A61F2002/041A61F2210/0095A61F2240/001A61L2300/44A61L2300/606C08L79/04
Inventor 张春富刘梅榕
Owner SHANGHAI JIAO TONG UNIV
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