Preparation method of amide compound
A technology of dehydration and condensation of amide compounds, applied in the preparation of organic compounds, carboxylic acid amide preparation, chemical instruments and methods, etc., can solve the problems of high cost of coupling reagents, many chemical wastes, cumbersome procedures, etc., and achieve easy separation Purification, broad substrate range, and simple operation
Pending Publication Date: 2022-01-11
WUHAN UNIV OF TECH
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Abstract
The invention relates to a preparation method of an amide compound. The method comprises the following steps: by taking amine and carboxylic acid as raw materials and bromomethylsulfonyl fluoride as a coupling reagent, carrying out dehydration condensation reaction in the presence of alkali and a solvent, and finally separating and purifying to obtain the amide compound. The preparation method has the characteristics of simplicity in operation, low preparation cost, easiness in separation and purification of products and the like, is wide in substrate range, can be used for condensation of amino acids and synthesis and modification of bioactive molecules, and is expected to be used for large-scale synthesis of amides.
Application Domain
Carbamic acid derivatives preparationOrganic compound preparation +1
Technology Topic
Sulfonyl fluorideCoupling reagent +9
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