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Application of tetrahydrocurcumin in preparation of medicine for preventing and/or treating type 2 diabetes mellitus complicated with non-alcoholic fatty liver

A technology of tetrahydrocurcumin and type 2 diabetes, applied in the field of application of tetrahydrocurcumin in the preparation of drugs for the prevention and/or treatment of type 2 diabetes combined with non-alcoholic fatty liver, to slow down inflammation and oxidative stress , reducing the accumulation, improving the effect of liver morphology

Pending Publication Date: 2022-03-01
SICHUAN CENT FOR TRANSLATIONAL MEDICINE OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no research report on tetrahydrocurcumin in the treatment of diabetes with fatty liver, especially for the prevention and treatment of type 2 diabetes with non-alcoholic fatty liver

Method used

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  • Application of tetrahydrocurcumin in preparation of medicine for preventing and/or treating type 2 diabetes mellitus complicated with non-alcoholic fatty liver
  • Application of tetrahydrocurcumin in preparation of medicine for preventing and/or treating type 2 diabetes mellitus complicated with non-alcoholic fatty liver
  • Application of tetrahydrocurcumin in preparation of medicine for preventing and/or treating type 2 diabetes mellitus complicated with non-alcoholic fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Discussion on the Mechanism of Tetrahydrocurcumin in Treating Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking Technology

[0040] Using network pharmacology method to predict and analyze the target of THC and explore its potential mechanism of prevention and treatment of type 2 diabetes. According to the chemical structure of tetrahydrocurcumin, the drug target was obtained by using the Pharmmapper database for target prediction. T2DM disease targets obtained by screening four databases of Pharmgkb, TTD, Disgenet, and genecard. Match the disease target with the drug target to obtain the common target. The STRING database was used for protein interaction analysis, and the metascape platform was used for GO enrichment analysis and KEGG pathway enrichment analysis. The compound-target-pathway diagram was constructed using Cytoscape3.7.1 software. According to the network screening results, a total of 103 targets of tetrahydrocurcum...

Embodiment 2 4

[0075] Example 2 Study on pharmacodynamics and mechanism of tetrahydrocurcumin in treating type 2 diabetes combined with non-alcoholic fatty liver model rats

[0076]Objective: To explore the effect of THC intervention on fatty acid oxidase and MAPK signaling pathway in rats with type 2 diabetes mellitus and nonalcoholic fatty liver disease. Methods: Among 24 male SD rats, 6 were randomly selected according to body weight as the normal group and given conventional diet, and the remaining 18 rats were fed with high-fat and high-sugar diet for 6 weeks, and then intraperitoneally injected streptozotocin to establish type 2 diabetes mellitus. Model of non-alcoholic fatty liver disease. Divided into normal group (equal volume of normal saline), model group (equal volume of normal saline), THC group (130mg·kg -1 ), metformin group (150mg·kg -1 ), rats in each group were gavaged for 8 weeks. Blood glucose was measured every two weeks during the administration period, blood was col...

Embodiment 3 4

[0118] Example 3 Tetrahydrocurcumin treatment of type 2 diabetes combined with non-alcoholic fatty liver model rats serum metabolomics research

[0119] Objective: To investigate the effect of THC on the metabolism of rats with type 2 diabetes mellitus complicated with non-alcoholic fatty liver. Method: Take the experimental rat serum in Example 2, use liquid chromatography-mass spectrometry (LC-MS) technology, combined with multiple analysis methods, analyze the endogenous metabolites in the rat serum and their changes, and look for THC intervention 2 Potential biomarkers in rats with type 2 diabetes and nonalcoholic fatty liver disease. Results: After THC intervention, the content changes of 33 metabolites were compared with those in the model group. Most of the metabolites are lysophosphatidylcholine (LPC) and TG, and THC can reduce its content, so as to slow down the inflammatory response and oxidative stress. In addition to lipids and lipid-like molecules, THC may also ...

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Abstract

The invention provides application of tetrahydrocurcumin or pharmaceutically acceptable salt thereof in preparation of a medicine for preventing and / or treating type 2 diabetes mellitus combined with non-alcoholic fatty liver. Through network pharmacology, pharmacodynamics and mechanism research and screening of rats with type 2 diabetes mellitus combined with non-alcoholic fatty liver, and serum metabonomics research, tetrahydrocurcumin is found to play roles in reducing blood sugar, liver weight index, insulin resistance, FFA, AST, ALT, TC, TG and LDL-C, increasing HDL-C, reducing accumulation of liver fat, reducing blood fat content, reducing blood fat content and reducing blood fat content through a multi-target and multi-channel cooperation mechanism. The traditional Chinese medicine composition has the effects of preventing and treating type 2 diabetes mellitus combined with non-alcoholic fatty liver disease, reducing cholesterol synthesis, improving liver morphology, slowing down inflammatory response and oxidative stress, and regulating serum metabolites, thereby achieving the purpose of preventing and treating type 2 diabetes mellitus combined with non-alcoholic fatty liver disease.

Description

technical field [0001] The invention relates to the use of tetrahydrocurcumin in preparing a medicine for treating type 2 diabetes combined with non-alcoholic fatty liver. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) is closely related to factors such as type 2 diabetes, obesity, dyslipidemia, insulin resistance (IR) and unhealthy diet. Vascular disease (CVD) is an independent risk factor and is currently the most common type of chronic liver disease in my country. In recent years, with the development of metabolic syndromes such as obesity and type 2 diabetes (T2DM), the prevalence and incidence of NAFLD have also increased year by year. A large number of epidemiological studies have shown that NAFLD is a global epidemic trend, the incidence rate of the general population in western countries is as high as 20% to 35%, and the accompanying rate of fatty liver in T2DM population is as high as 57% to 80%. Type 2 diabetes is not only a risk factor fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P3/10A61P1/16A61P5/50A61P3/06
CPCA61K31/12A61P3/10A61P1/16A61P5/50A61P3/06
Inventor 王剑波袁权尤晓舟龚晓丽戴瑛赵军宁
Owner SICHUAN CENT FOR TRANSLATIONAL MEDICINE OF TRADITIONAL CHINESE MEDICINE
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