Pure beta ray corrying safe microball and its preparation

A β-ray and safe technology, applied in radiotherapy, radioactive carriers, radioactive physical shapes, etc., can solve problems such as patient health hazards, and achieve the effects of reliable safety, simple and easy-to-control preparation methods, and strong killing ability.

Inactive Publication Date: 2004-03-10
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with polymer resin microspheres Although the radioisotopes of the above two patents are relatively firmly combined with the vitreous body, the common disadvantage is that there is still a phenomenon that some radionuclides are leached out from the glass microspheres, and they dissolve in the blood, which brings harm to the patient. Health hazards, and the glass microspheres of the previous patent also contain impurity rays of considerable strength in addition to beta rays

Method used

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  • Pure beta ray corrying safe microball and its preparation
  • Pure beta ray corrying safe microball and its preparation
  • Pure beta ray corrying safe microball and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 100 grams will contain Y 2 O 3 , SiO 2 , Al 2 O 3 The Y-89 glass microspheres 1 are placed in a container, 0.4 g of silane coupling agent surfactant is added, and the pretreatment is completed by stirring 3, and then immersed in a sol containing 100% ethyl orthosilicate solution, and placed in a magnetic stirring On the stage, the gelatinization coating treatment 4 is carried out with stirring, and then the solid-liquid separation 5 is carried out. After organic solvent, ageing at room temperature for 25 days to stabilize the polymerization 7, and finally heating and evaporating heat treatment 8 at 500-600 ° C in a muffle furnace to make it vitrified, that is, the surface of the present invention has SiO 2 Coated yttrium-containing security microspheres. The diameter of the safety glass microspheres is in the range of 20 to 60 μm. Coated with SiO 2 The coated glass microspheres have a 30-day yttrium dissolution rate of 9 × 10 in a physiological simulant -7 g / g, ...

Embodiment 2

[0020] 100 grams will contain P 2 O 5 , Al 2 O 3 , MgO P-31 glass microspheres 1 in 0.5 g polyethylene glycol, stir to make it wet, and complete the pretreatment 3. Then, the above-mentioned glass microspheres 1 are immersed in a sol solution containing 80-90% of ethyl orthosilicate and 10-20% of aluminum nitrate, which can form a corrosion-resistant coating 2, and stirred to perform gelation coating treatment 4 , through the above-mentioned glass microsphere gel substance, carry out solid-liquid separation 5, take out the glass microspheres 1 coated with sol, and carry out cyclone together with the dry 40-60 ℃ hot air entering in the same direction at the inlet of the cyclone dryer Drying 6, removing part of the organic solvent and aging at room temperature for 30 days to stabilize the polymerization 7, and finally heating and evaporating heat treatment at 400-500°C in a muffle furnace 8, making it vitrified, and obtaining a surface with SiO 2 and Al 2 O 3 Coated phosph...

Embodiment 3

[0021] 100 grams will contain P 2 O 5 , Al 2 O 3 , MgO P-31 glass microspheres 1 in 0.5 g polyethylene glycol, stir to make it wet, and complete the pretreatment 3. Then, the above-mentioned glass microspheres 1 are immersed in a sol solution containing 80-95% of ethyl orthosilicate and 5-20% of butyl titanate which can form a corrosion-resistant coating 2 and stirred to perform gel coating. Treatment 4, the above-treated glass microsphere gel substance is subjected to solid-liquid separation 5, the sol-coated glass microspheres 1 are taken out, and the dry 40-60 ℃ hot air entering in the same direction at the inlet of the cyclone dryer Perform cyclone drying 6, remove part of the organic solvent and age at room temperature for 30 days to stabilize the polymerization 7, and finally heat it in a muffle furnace at 400-500 ℃ for heat treatment 8 to make it vitrified to obtain a surface with SiO 2 and TiO2 Coated phosphorus-containing safety microspheres. The diameter of the ...

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Abstract

The present invention relates to a glass microphere with pure beta-rays capable of producing action for curing carcinoma after having been activated and its preparation process. It is made up by using glass microsphere with pure beta-rays and anticorrosive coating layer applied onto external surface of the glass microsphere by adopting sol-gel method. The advantages of said invention lies in that the radioisotope in not easy to be penetrated into blood, the external physiological simulation liquid soaking test shows that the resolution of its correspondent nuclein is reduced by 1-2 orders of magnitude as compared with resolution of nucleic of microsphere without anticorrosive coating layer, it has no radioactive pollution, and its chemical stability is high. Said invention is simple in preparation process, its operation is safe and reliable, can be extensively used for radiotherapy to cure carcinoma.

Description

technical field [0001] The invention relates to a glass microsphere with high chemical stability and a pure beta ray for cancer treatment after being activated by neutrons and a process thereof. Background technique [0002] Surgery, chemotherapy and radiotherapy are the traditional methods of cancer treatment. As we all know, radiotherapy is more targeted and flexible than chemotherapy, and cancer patients are more willing to use radiotherapy for direct treatment, so that the tumor can shrink and get the opportunity for surgery, or the tumor cells can be completely killed and necrotic. Although cancer cells absorb radiation more easily than normal cells, normal cells are still damaged by radiation. Therefore, the radiation dose of external radiotherapy is generally not large enough to kill all cancer cells, which also affects the efficacy. In the early 1980s, interventional internal radiation therapy was started abroad. The isotopes that emit radiation are complexed with ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/02A61K51/12A61N5/00A61P35/00C03C17/23
Inventor 黄文旵钱达兴周萘吴知方茅波
Owner TONGJI UNIV
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