Traditional Chinese medicine syndrome differentiation and typing system for early breast cancer chemotherapy period and construction method and application of traditional Chinese medicine syndrome differentiation and typing system
A construction method, breast cancer technology, applied in medical informatics, medical data mining, computer-aided medical procedures, etc. Deficiency, spleen and stomach disharmony, liver and kidney deficiency and other problems, to achieve the effect of broad application prospects
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Embodiment 1
[0051] Example 1 Collection and entry of TCM syndrome information for breast cancer chemotherapy patients
[0052] 1) Source of cases: Collected from December 2019 to January 2021, a total of 400 patients with malignant breast tumors treated with chemotherapy at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine and Cancer Hospital Affiliated to Shanghai Fudan University .
[0053] 2) Diagnostic criteria: refer to "Surgery" (editor-in-chief: Chen Xiaoping, Beijing: People's Health Publishing House, 2nd edition in August 2010). Combined with the patient's clinical manifestations, physical examination, imaging examination, and pathological examination, it was diagnosed as breast cancer. Postoperative TNM staging was based on the American Joint Committee on Cancer AJCC 2010 edition; breast cancer molecular typing was based on the St.Gallen Consensus.
[0054] 3) Inclusion criteria: ① female; ...
Embodiment 2
[0061] Example 2 Cluster analysis method to establish a candidate system for TCM syndrome differentiation in the chemotherapy period of early breast cancer
[0062] ①Syndrome entry screening of TCM syndrome differentiation and typing during breast cancer chemotherapy: the syndrome entries were sorted by frequency analysis method, the syndrome entries with frequency 0 were kept and included as TCM syndrome differentiation during the chemotherapy period of early breast cancer. Diagnostic metrics for typing candidate systems. i. Retrieve the binary classification information in the TCM syndrome database during the chemotherapy period of breast cancer, and carry out logistic regression analysis through SPSS software to obtain the original weight coefficient of each syndrome entry;
[0063] ii. Set the total score of each syndrome type in the TCM syndrome differentiation candidate system obtained in step 3-3 as M, and calculate the weight coefficient of the syndrome entry correspo...
Embodiment 3
[0078] Example 3 Screening and Determining the TCM Syndrome Differentiation and Typing System of Early Breast Cancer During Chemotherapy
[0079] According to the cluster analysis results recorded in Table 2-5, screened according to the screening criteria, the result: the weight coefficient of dark tongue in category II of scheme one (grouping three categories) is 40, and this scheme is eliminated; scheme three (grouping five categories) In category I, the weight coefficient of purple tongue is 50, and this scheme is eliminated; in scheme four (grouping six categories), the weight coefficient of pulse sinking in category I is 31, the weight coefficient of pulse sinking in category II is 48, and the weight coefficient of dark tongue in category V The coefficient is 27, and the weight coefficient of vein fineness in category VI is 37, so this scheme should be eliminated. The second plan (grouping of four categories) is finally reserved.
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