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Traditional Chinese medicine syndrome differentiation and typing system for early breast cancer chemotherapy period and construction method and application of traditional Chinese medicine syndrome differentiation and typing system

A construction method, breast cancer technology, applied in medical informatics, medical data mining, computer-aided medical procedures, etc. Deficiency, spleen and stomach disharmony, liver and kidney deficiency and other problems, to achieve the effect of broad application prospects

Pending Publication Date: 2022-03-11
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, some scholars have used statistical methods to conduct research on syndrome types. However, literature reviews have found that breast cancer staging and syndrome differentiation studies have relatively large-scale and high-level evidence in the consolidation period, perioperative period, and late period. According to clinical research reports, the research on syndrome differentiation during chemotherapy is still mostly based on the experience of doctors. For example, Professor Lin Yi mainly distinguishes the deficiency of Qi and Yin, deficiency of both Qi and blood, disharmony of spleen and stomach, and deficiency of liver and kidney in patients with breast cancer during chemotherapy; Professor Li Tong believes that chemotherapy patients mostly suffer from deficiency of both qi and yin, and hyperactivity of fire due to yin deficiency, and there are few studies on macroscopic syndrome differentiation based on large samples
At the same time, in most studies, the use of traditional Chinese medicine is mostly the own experience of each research group, lacking the basis of syndrome differentiation and treatment
Although traditional Chinese medicine is widely used in breast cancer chemotherapy and has achieved certain clinical curative effects, it has not been widely recognized and promoted in clinical practice due to the lack of more scientific and objective support for syndrome differentiation.

Method used

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  • Traditional Chinese medicine syndrome differentiation and typing system for early breast cancer chemotherapy period and construction method and application of traditional Chinese medicine syndrome differentiation and typing system
  • Traditional Chinese medicine syndrome differentiation and typing system for early breast cancer chemotherapy period and construction method and application of traditional Chinese medicine syndrome differentiation and typing system
  • Traditional Chinese medicine syndrome differentiation and typing system for early breast cancer chemotherapy period and construction method and application of traditional Chinese medicine syndrome differentiation and typing system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 Collection and entry of TCM syndrome information for breast cancer chemotherapy patients

[0052] 1) Source of cases: Collected from December 2019 to January 2021, a total of 400 patients with malignant breast tumors treated with chemotherapy at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine and Cancer Hospital Affiliated to Shanghai Fudan University .

[0053] 2) Diagnostic criteria: refer to "Surgery" (editor-in-chief: Chen Xiaoping, Beijing: People's Health Publishing House, 2nd edition in August 2010). Combined with the patient's clinical manifestations, physical examination, imaging examination, and pathological examination, it was diagnosed as breast cancer. Postoperative TNM staging was based on the American Joint Committee on Cancer AJCC 2010 edition; breast cancer molecular typing was based on the St.Gallen Consensus.

[0054] 3) Inclusion criteria: ① female; ...

Embodiment 2

[0061] Example 2 Cluster analysis method to establish a candidate system for TCM syndrome differentiation in the chemotherapy period of early breast cancer

[0062] ①Syndrome entry screening of TCM syndrome differentiation and typing during breast cancer chemotherapy: the syndrome entries were sorted by frequency analysis method, the syndrome entries with frequency 0 were kept and included as TCM syndrome differentiation during the chemotherapy period of early breast cancer. Diagnostic metrics for typing candidate systems. i. Retrieve the binary classification information in the TCM syndrome database during the chemotherapy period of breast cancer, and carry out logistic regression analysis through SPSS software to obtain the original weight coefficient of each syndrome entry;

[0063] ii. Set the total score of each syndrome type in the TCM syndrome differentiation candidate system obtained in step 3-3 as M, and calculate the weight coefficient of the syndrome entry correspo...

Embodiment 3

[0078] Example 3 Screening and Determining the TCM Syndrome Differentiation and Typing System of Early Breast Cancer During Chemotherapy

[0079] According to the cluster analysis results recorded in Table 2-5, screened according to the screening criteria, the result: the weight coefficient of dark tongue in category II of scheme one (grouping three categories) is 40, and this scheme is eliminated; scheme three (grouping five categories) In category I, the weight coefficient of purple tongue is 50, and this scheme is eliminated; in scheme four (grouping six categories), the weight coefficient of pulse sinking in category I is 31, the weight coefficient of pulse sinking in category II is 48, and the weight coefficient of dark tongue in category V The coefficient is 27, and the weight coefficient of vein fineness in category VI is 37, so this scheme should be eliminated. The second plan (grouping of four categories) is finally reserved.

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Abstract

The invention discloses an early breast cancer chemotherapy period traditional Chinese medicine syndrome differentiation typing system which comprises four syndrome types, namely liver depression yin deficiency syndromes, corresponding syndrome items including dysphoria and irritability, thin and white tongue coating, amnesia, chest and hypochondrium swelling pain, dry mouth, hectic fever, chest and abdominal pain, ostalgia, abdominal distension and chest distress; the corresponding syndrome items of the qi-yin deficiency syndrome include deep pulse, thin and white tongue coating, red tongue, hectic fever, amnesia, dry mouth, pale complexion, soreness and weakness of waist and knees, spontaneous perspiration and ruddy complexion; the corresponding syndrome items of the spleen deficiency and hemophthisis are light white tongue color, white and greasy tongue coating, pale complexion, dry mouth, poor appetite, fine pulse and fat and big tongue; the corresponding syndrome items of the qi stagnation and blood stasis syndrome include ecchymosis on the tongue, cyan and purple mouth and lips, collaterals under the tongue, pulse strings, gloomy complexion, numbness of limbs and dental ulcer. The invention further discloses a construction method and application of the system. The invention provides a theoretical basis for standardized traditional Chinese medicine treatment of early breast cancer chemotherapy period patients, and has a wide application prospect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine syndrome differentiation system for early breast cancer chemotherapy and its construction method and application. Background technique [0002] Breast cancer is the most common malignant tumor in women, and its incidence in my country is increasing year by year. At present, the comprehensive treatment of breast cancer has formed a relatively standardized and reasonable treatment mode. Adjuvant chemotherapy as a main treatment method can enable patients to obtain better benefits and survival time, reduce the recurrence and metastasis rate, and improve disease-free survival. Expect. However, toxic and side effects of chemotherapy such as leukopenia, impaired liver function, hair loss, and mouth sores often make patients daunting. Long-term clinical application has found that the combined treatment of traditional Chinese medici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H20/90G16H50/70
CPCG16H20/90G16H50/70
Inventor 盛佳钰李春阳江科董梦婷帕提古丽·加帕尔袁敏佳李晓菲
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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