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Preparation method for constructing photodynamic antibacterial osteogenesis-promoting dexamethasone/hydroxyapatite coating by using polypyrrole to regulate and control copper nanoparticles

A photodynamic antibacterial and hydroxyapatite technology, applied in photodynamic therapy, medical preparations containing active ingredients, coatings, etc., can solve problems affecting surface plasmon resonance, cytotoxicity, and reduced antibacterial ability , to achieve good application prospects, promote angiogenesis, and easy to operate

Pending Publication Date: 2022-04-22
XINJIANG NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the agglomeration of Cu-NPs in the application process affects its surface plasmon resonance, reduces its antibacterial ability, and produces toxicity to cells.

Method used

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  • Preparation method for constructing photodynamic antibacterial osteogenesis-promoting dexamethasone/hydroxyapatite coating by using polypyrrole to regulate and control copper nanoparticles
  • Preparation method for constructing photodynamic antibacterial osteogenesis-promoting dexamethasone/hydroxyapatite coating by using polypyrrole to regulate and control copper nanoparticles
  • Preparation method for constructing photodynamic antibacterial osteogenesis-promoting dexamethasone/hydroxyapatite coating by using polypyrrole to regulate and control copper nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method of polypyrrole regulating copper nanoparticles to construct a photodynamic antibacterial and promoting bone dexamethasone / hydroxyapatite coating, comprising the following steps:

[0027] (1) Grind medical titanium and its alloys with sandpaper until the titanium surface has no black stains and presents a silver-white metallic luster; clean the polished titanium sheet with acetone for 10 min under ultrasonic waves, and repeat 3 times; after cleaning with acetone, wash it with distilled water Ultrasonic cleaning for 10 minutes, repeated 3 times, the amount of acetone and distilled water should not exceed the titanium sheet; prepare a mixed acid with a volume ratio of concentrated sulfuric acid (98%), concentrated hydrochloric acid (36%), and water at a volume ratio of 1:1:1, and process in the previous step The good titanium pieces are placed in mixed acid, and treated in a water bath at a constant temperature of 60 °C for 5 hours under sealed conditio...

Embodiment 2

[0032] A preparation method of polypyrrole regulating copper nanoparticles to construct a photodynamic antibacterial and promoting bone dexamethasone / hydroxyapatite coating, comprising the following steps:

[0033] (1) Grind medical titanium and its alloys with sandpaper until the titanium surface has no black stains and presents a silver-white metallic luster; clean the polished titanium sheet with acetone for 10 min under ultrasonic waves, and repeat 3 times; after cleaning with acetone, wash it with distilled water Ultrasonic cleaning for 10 minutes, repeated 3 times, the amount of acetone and distilled water should not exceed the titanium sheet; prepare a mixed acid with a volume ratio of concentrated sulfuric acid (98%), concentrated hydrochloric acid (36%), and water at a volume ratio of 1:1:1, and process in the previous step The good titanium pieces are placed in mixed acid, and treated in a water bath at a constant temperature of 60 °C for 5 hours under sealed conditio...

Embodiment 3

[0037] A preparation method of polypyrrole regulating copper nanoparticles to construct a photodynamic antibacterial and promoting bone dexamethasone / hydroxyapatite coating, comprising the following steps:

[0038] (1) Grind medical titanium and its alloys with sandpaper until the titanium surface has no black stains and presents a silver-white metallic luster; clean the polished titanium sheet with acetone for 10 min under ultrasonic waves, and repeat 3 times; after cleaning with acetone, wash it with distilled water Ultrasonic cleaning for 10 minutes, repeated 3 times, the amount of acetone and distilled water should not exceed the titanium sheet; prepare a mixed acid with a volume ratio of concentrated sulfuric acid (98%), concentrated hydrochloric acid (36%), and water at a volume ratio of 1:1:1, and process in the previous step The good titanium pieces are placed in mixed acid, and treated in a water bath at a constant temperature of 60 °C for 5 hours under sealed conditio...

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PUM

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Abstract

The invention discloses a preparation method for constructing a photodynamic antibacterial osteogenesis-promoting dexamethasone / hydroxyapatite coating by using polypyrrole to regulate and control copper nanoparticles, and the method integrates the coordination effect of polypyrrole on metal ions, the broad-spectrum antibacterial property and blood vessel promoting function of copper, and the responsiveness characteristic of copper nanoparticles on near-infrared light. The composite coating with photo-thermal accelerated sterilization, angiogenesis promotion and bone formation stimulation under the irradiation of 808 nm light is prepared by using the characteristics of dexamethasone, hydroxyapatite and pulse electrochemistry, the osteogenesis promotion characteristic of dexamethasone, the good biocompatibility of hydroxyapatite and the unique advantages of pulse electrochemistry in the aspect of construction of a coating with controllable morphology, and the composite coating with the functions of photo-thermal accelerated sterilization, angiogenesis promotion and bone formation stimulation under the irradiation of 808 nm light is prepared. The material can be widely applied to the fields of bone injury repair and bone defect treatment as a bone repair material.

Description

technical field [0001] The invention relates to a preparation method of a bionic bone tissue composite material, in particular to a preparation method of polypyrrole regulating copper nanoparticles to construct a photodynamic antibacterial and bone-promoting dexamethasone / hydroxyapatite coating. Background technique [0002] Increasing number of fractures related to aging population, orthopedic diseases, and osteoporosis has resulted in growing demand for artificial implant materials. Titanium and its alloys are widely used in the manufacture of artificial bone repair materials due to their good mechanical properties, compatibility with cells, and closeness to the elastic modulus of cortical bone. However, titanium and its alloys lack biological activity, no antibacterial ability, and insufficient osseointegration ability. Therefore, it is of great significance to endow titanium and its alloys with antibacterial and osteogenic properties. [0003] Hydroxyapatite (HA) conta...

Claims

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Application Information

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IPC IPC(8): C25D3/38C25D5/18C25D9/02C25D9/04A61L27/06A61L27/32A61L27/30A61L27/28A61L27/34A61L27/50A61L27/54A61K41/00A61P31/04
CPCC25D3/38C25D5/18C25D9/02C25D9/04A61L27/06A61L27/32A61L27/306A61L27/28A61L27/34A61L27/50A61L27/54A61K41/0052A61K41/0057A61P31/04A61L2300/404A61L2300/43A61L2430/02A61L2300/412A61L2420/02A61L2420/04A61L2420/06A61L2300/606A61L2400/12C08L79/04
Inventor 王英波骆江洪张小楠尹辉
Owner XINJIANG NORMAL UNIVERSITY
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