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Quantum dot-MXene fluorescence sensor as well as preparation method and application thereof

A fluorescent sensor and graphene quantum dot technology, which is applied in the construction and application of chemical sensors, can solve the problems of low fluorescence quantum yield of noble metal nanoclusters, non-negligible surface defects, and toxic half-quantum dots, and achieve shortened detection time, Low cost, good quenching effect

Active Publication Date: 2022-05-10
SPECIAL EQUIP SAFETY SUPERVISION INSPECTION INST OF JIANGSU PROVINCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The discovery of organic fluorophores has fundamentally changed the landscape of biomedical research, but poor photostability makes long-term imaging difficult; semiconductor quantum dots are considered a promising alternative due to their high fluorescence intensity and photostability, but semi-quantum Toxic and insoluble
Metal nanoclusters exhibit lower toxicity and satisfactory renal clearance, but the fluorescence quantum yields of most noble metal nanoclusters are still low
Although rare-earth upconversion nanoparticles have many excellent advantages over other fluorescent counterparts, they still suffer from poor luminescence efficiency due to many factors such as low absorption efficiency, non-negligible surface defects, concentration quenching, etc.

Method used

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  • Quantum dot-MXene fluorescence sensor as well as preparation method and application thereof
  • Quantum dot-MXene fluorescence sensor as well as preparation method and application thereof
  • Quantum dot-MXene fluorescence sensor as well as preparation method and application thereof

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Effect test

Embodiment 1

[0044] The construction method of graphene quantum dot-MXene fluorescent sensor described in the present embodiment comprises the steps:

[0045] (1) Preparation of functionalized graphene quantum dots (Glu-His-GQD): citric acid (0.03mol), glutathione (0.01mol) and histidine (0.03mol) were mixed and dissolved in ultrapure water ( The mass ratio of the total amount of citric acid, glutathione and histidine to water was 1:1), and then evaporated at 80° C. for 2 h to remove all the water. Then, the mixture was heated at 180°C for 3 h to obtain Glu-His-GQD solid powder, which was dissolved in ultrapure water and neutralized to pH 7.0 with NaOH solution to form a transparent Glu-His-GQD solid powder. GQDs solution (20mg / ml). The solution was dialyzed in a dialysis bag with a molecular weight cut-off of 3 kDa, changing the water every 6 hours. Collect the solution in the bag, then vacuum dry at 60°C for 7 hours to obtain the Glu-His-GQD product;

[0046] (2) Preparation of aptame...

Embodiment 2

[0050] The construction method of graphene quantum dot-MXene fluorescent sensor described in the present embodiment comprises the steps:

[0051] (1) Preparation of functionalized graphene quantum dots (Glu-His-GQD): citric acid (0.01mol), glutathione (0.01mol) and histidine (0.01mol) were mixed and dissolved in ultrapure water ( The mass ratio of the total amount of citric acid, glutathione and histidine to water was 5:1), and then evaporated at 80° C. for 2 h to remove all the water. Then, the mixture was heated at 200°C for 2 h to obtain Glu-His-GQD solid powder, which was dissolved in ultrapure water and neutralized to pH 7.0 with NaOH solution to form a transparent Glu-His-GQD solid powder. GQDs solution (20mg / ml). The solution was dialyzed in a dialysis bag with a molecular weight cut-off of 3 kDa, changing the water every 6 hours. Collect the solution in the bag, then vacuum dry at 80°C for 3 hours to obtain the Glu-His-GQD product;

[0052] (2) Preparation of aptame...

Embodiment 3

[0056] The construction method of graphene quantum dot-MXene fluorescent sensor described in the present embodiment comprises the steps:

[0057] (1) Preparation of functionalized graphene quantum dots (Glu-His-GQD): citric acid (0.05mol), glutathione (0.01mol) and histidine (0.01mol) were mixed and dissolved in ultrapure water ( The mass ratio of the total amount of citric acid, glutathione and histidine to water was 3:1), and then evaporated at 80° C. for 2 h to remove all the water. Then, the mixture was heated at 160°C for 5 h to obtain Glu-His-GQD solid powder, which was dissolved in ultrapure water and neutralized to pH 7.0 with NaOH solution to form a transparent Glu-His- GQDs solution (20mg / ml). The solution was dialyzed in a dialysis bag with a molecular weight cut-off of 3 kDa, changing the water every 6 hours. Collect the solution in the bag, and then vacuum-dry it at 75°C for 4 hours to obtain the Glu-His-GQD product;

[0058] (2) Preparation of aptamer linker: ...

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Abstract

The invention discloses a quantum dot-MXene fluorescence sensor as well as a preparation method and application thereof. The preparation method disclosed by the invention comprises the following steps: (1) preparing a Glu-His-GQDs product; (2) preparing an aptamer connector; (3) preparing an MXene solution; and (4) preparing the graphene quantum dot-MXene fluorescence sensor. The fluorescence sensor prepared by the invention has the characteristics of easiness in synthesis, low cost, high light stability and low toxicity, has high sensitivity and high specificity on omethoate, and has wide application prospects in environmental monitoring and food safety monitoring in the market.

Description

technical field [0001] The invention relates to the technical field of construction and application of chemical sensors, in particular to a quantum dot-MXene fluorescence sensor and its preparation method and application. Background technique [0002] Organophosphorus pesticides are widely used as insecticides, fungicides and herbicides and have been used for decades in the control of agricultural pests worldwide. The widespread use of organophosphorus pesticides in contaminated water resources, fruits, vegetables, and processed foods can adversely affect the health of various non-target organisms such as birds, fish, and humans, and major Acute toxicity is the inhibition of acetylcholinesterase activity, resulting in accumulation of choline toxicity. The excessive use of organophosphorus pesticides poses a threat to human health and harms the ecology, so it is very important to develop effective detection methods. Omethoate is an organophosphorus pesticide with the simple...

Claims

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Application Information

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IPC IPC(8): G01N21/64C09K11/02C09K11/65
CPCG01N21/6428C09K11/025C09K11/65G01N2021/6432G01N2021/6439
Inventor 杨永强王勤生李在均王群区炳显丁杰
Owner SPECIAL EQUIP SAFETY SUPERVISION INSPECTION INST OF JIANGSU PROVINCE
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