Pharmaceutical preparation containing racecadotril and preparation method thereof

A technology for racecadotril and pharmaceutical preparations, which is applied in the field of pharmaceutical preparations containing racecadotril and its preparation, and can solve the problems of insignificant taste-masking effect, reduced dissolution rate, low solubility of racecadotril, etc. , to achieve the effect of improving water vapor permeability and tension, increasing film forming temperature, and good drug loading performance
CN114469873AActive Publication Date: 2022-05-13BEIJING CHILDRENS HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING CHILDRENS HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Publication Date
2022-05-13

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Abstract

The invention discloses a pharmaceutical preparation containing racecadotril and a preparation method thereof, and belongs to the field of pharmaceutical preparations. The preparation comprises racecadotril, a taste masking material, a filling agent, a flavoring agent and a lubricant, the taste masking material is composed of NE30D and ethyl cellulose fine powder according to a certain proportion, and further aggregation of an acrylate copolymer is prevented through formation of an incompatible phase between ethyl cellulose and acrylate copolymer particles; the water vapor permeability and tension of the membrane are improved, so that the drug release rate is stabilized, the bitter taste of the drug is effectively covered, and the membrane is suitable for acute diarrhea treatment of infant and child patients; the product stability is good; the preparation method has the advantages of good drug entrapment performance, good taste masking effect, and simple preparation process by adopting a conventional wet granulation process, and is more suitable for industrial production.
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Description

technical field

[0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a pharmaceutical preparation containing racecadotril and a preparation method thereof. Background technique

[0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art.

[0003] Racecadotril (Racecadotril) is a kind of enkephalinase inhibitor, is the antidiarrheal drug of a kind of new mechanism of action developed by French Bioproject company, and it can inhibit enkephalinase selectively and reversibly, thereby Protect endogenous enkephalins from degradation, prolong the physiological activity of endogenous enkephalins in the digestive tract, directly inhibit the excessive secretion of ...

Claims

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