Antibacterial hydrogel loaded with pH response type microcarrier as well as preparation method and application of antibacterial hydrogel

Abstract

The invention discloses antibacterial hydrogel loaded with a pH response type microcarrier and a preparation method and application thereof.The hydrogel comprises polyacrylamide hydrogel and composite microspheres, the composite microspheres comprise calcium alginate microspheres loaded with a vascular endothelial growth factor (VEGF), the calcium alginate microspheres are covered with a polydopamine coating, and the polydopamine coating is coated with a pH response type microcarrier. The polydopamine coating comprises polydopamine microspheres, and silver nanoparticles are attached to the surfaces of the polydopamine microspheres. The hydrogel is polyacrylamide hydrogel grafted with composite microspheres, slow and controlled release of VEGF is achieved through polydopamine coatings coated on the surfaces of calcium alginate microspheres loaded with the VEGF, and under the combined action of nano-silver ions formed by in-situ reduction and attached to the polydopamine microspheres, the VEGF can be released slowly and slowly, so that the VEGF can be released slowly and slowly. The hydrogel is endowed with toughness, adhesion, oxidation resistance, antibacterial property and vascularization promotion performance.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to an antibacterial hydrogel loaded with pH-responsive microcarriers, a preparation method and application thereof. Background technique [0002] The skin is the largest multi-layered organ in the human body, including the epidermis and dermis. Once the epidermis is damaged, the skin will lose its most basic protective function. If the wound cannot be treated effectively in time, the wound is easily colonized by pathogens such as Escherichia coli and Staphylococcus aureus, and microbial infection at the wound site will seriously prolong the healing process and form a chronically infected wound. Although the development of antibacterial materials has made progress, there is still a lack of ideal wound repair materials for infected wound healing. The main problems are that they cannot control and prevent bacterial infections well and prolong the inflammatory p...

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Problems solved by technology

[0004] Vascular endothelial growth factor (VEGF) is a highly specific growth factor for promoting vascular endothelial cells, which can promote the increase of vascular permeability, extracellular matrix degeneration, vascular Endothelial cell migration, proliferation and angiogenesis, etc. However, the half-life of VEGF in the body is very short, which greatly affects its effectiveness as a signaling molecule. In addition, excessive VEGF can cause bleeding, and there may be negative feedback control , that is, cells may stop receiving extracellular VEGF signals by down-regulating the level of VEGF membrane receptors. How to realize the intelligent and sustained release of VEGF at the wound and maintain the VEGF concentration at the required standard during the treatment window period is still a challenge

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