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Preparation of romidepsin-loaded heterojunction nanoparticles with sonodynamic effect

A nanoparticle and heterojunction technology, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, and materials for wave energy or particle radiation treatment, etc., can solve the problem of fast blood removal and shallow tissue penetration depth. , large toxic and side effects, etc., to achieve good dispersion and stability, enhance the therapeutic effect, and induce cell apoptosis.

Pending Publication Date: 2022-06-24
SOUTHWEST UNIVERSITY
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Problems solved by technology

[0004] In view of the fact that the drug delivery carrier currently used for tumor treatment has a single function and the therapeutic effect is not good, the traditional photodynamic therapy has a shallow tissue penetration depth and has certain harm to normal tissues, and the small molecule chemotherapy drugs have poor targeting and toxic side effects. The present invention aims to synthesize a novel drug delivery platform with high biocompatibility, long circulation time in vivo and synergistic therapy of sonodynamics and chemotherapy

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  • Preparation of romidepsin-loaded heterojunction nanoparticles with sonodynamic effect
  • Preparation of romidepsin-loaded heterojunction nanoparticles with sonodynamic effect
  • Preparation of romidepsin-loaded heterojunction nanoparticles with sonodynamic effect

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Embodiment 1

[0027] Example 1 Preparation of heterojunction nanoparticles loaded with romidepsin with acoustodynamic effect

[0028] The synthesis principle of heterojunction nanoparticles loaded with romidepsin with acoustodynamic effect is as follows figure 1 shown, including the following synthesis steps:

[0029](1) Preparation of mid-cavity mesoporous titanium dioxide nanoparticles: First, 4 mL of polyvinylpyrrolidone PVP K30 aqueous solution (83.75 mg / mL), 27.6 mL of absolute ethanol and 0.1 mol / L of hydrochloric acid were magnetically stirred at room temperature for 20 min. A mixed dispersion was obtained; then 2.5 mL of titanium tetrafluoride aqueous solution (4.96 mg / mL) was added dropwise to the above dispersion, and slowly stirred at room temperature for 1 h to obtain a mixed solution; the above mixed solution was transferred to a stainless steel autoclave , the temperature was programmed to 180 °C for 3 h, and then the temperature was programmed to cool to room temperature to ...

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Abstract

The invention discloses preparation of a romidepsin-loaded heterojunction nanoparticle with a sonodynamic effect, which is a novel nanoparticle material taking pharmaceutical chemistry as a synthesis basis and is used for tumor treatment by utilizing the specific excellent properties of the romidepsin-loaded heterojunction nanoparticle. The preparation method specifically comprises the following steps: (1) preparing mesoporous titanium dioxide; (2) preparation of carbon nitride quantum dots (g-C3N4 QD) and composite preparation of the carbon nitride quantum dots and a titanium dioxide material; (3) loading an endogenous response small molecule drug romidepsin, so as to prepare a romidepsin-loaded heterojunction nano particle with a sonodynamic effect; and (4) verifying the successful synthesis of the nanoparticles and the synergistic treatment effect of sonodynamic and chemotherapy through experiments. The finally obtained nanoparticle complex has good dispersibility, biocompatibility and good tumor treatment effect, and has great application potential in the field of biomedicine and other fields of social economy.

Description

technical field [0001] The invention relates to the field of chemical medicines, in particular to the preparation and use of heterojunction nanoparticles carrying romidepsin and having an acoustic dynamic effect. Background technique [0002] With the development of nanobiomedicine, more and more researchers are devoted to studying the application of nanomaterials in minimally invasive and non-invasive treatment of cancer. This method can not only precisely target cancer cells, but also have more accurate At the same time, it can ensure the integrity of normal tissues and cells, greatly improve the therapeutic effect and reduce adverse effects. Sonodynamic therapy for cancer is a new type of non-invasive treatment, which has a good therapeutic effect in tumor treatment. It can stimulate the sonosensitizer to generate toxic reactive oxygen species through ultrasound, thereby killing cancerous cells in the tissue. Among them, inorganic nanomaterials have the characteristics o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K41/00A61K38/15A61K47/54A61P35/00
CPCA61K38/15A61K41/0033A61K47/54A61K9/0009A61K41/0047A61P35/00A61K9/145A61K2300/00
Inventor 薛鹏何梦婷张蕾刘晓喆张芷瑜
Owner SOUTHWEST UNIVERSITY
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