Preparation of romidepsin-loaded heterojunction nanoparticles with sonodynamic effect

Abstract

The invention discloses preparation of a romidepsin-loaded heterojunction nanoparticle with a sonodynamic effect, which is a novel nanoparticle material taking pharmaceutical chemistry as a synthesis basis and is used for tumor treatment by utilizing the specific excellent properties of the romidepsin-loaded heterojunction nanoparticle. The preparation method specifically comprises the following steps: (1) preparing mesoporous titanium dioxide; (2) preparation of carbon nitride quantum dots (g-C3N4 QD) and composite preparation of the carbon nitride quantum dots and a titanium dioxide material; (3) loading an endogenous response small molecule drug romidepsin, so as to prepare a romidepsin-loaded heterojunction nano particle with a sonodynamic effect; and (4) verifying the successful synthesis of the nanoparticles and the synergistic treatment effect of sonodynamic and chemotherapy through experiments. The finally obtained nanoparticle complex has good dispersibility, biocompatibility and good tumor treatment effect, and has great application potential in the field of biomedicine and other fields of social economy.

Description

technical field [0001] The invention relates to the field of chemical medicines, in particular to the preparation and use of heterojunction nanoparticles carrying romidepsin and having an acoustic dynamic effect. Background technique [0002] With the development of nanobiomedicine, more and more researchers are devoted to studying the application of nanomaterials in minimally invasive and non-invasive treatment of cancer. This method can not only precisely target cancer cells, but also have more accurate At the same time, it can ensure the integrity of normal tissues and cells, greatly improve the therapeutic effect and reduce adverse effects. Sonodynamic therapy for cancer is a new type of non-invasive treatment, which has a good therapeutic effect in tumor treatment. It can stimulate the sonosensitizer to generate toxic reactive oxygen species through ultrasound, thereby killing cancerous cells in the tissue. Among them, inorganic nanomaterials have the characteristics o...

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Problems solved by technology

[0004] In view of the fact that the drug delivery carrier currently used for tumor treatment has a single function and the therapeutic effect is not good, the traditional photodynamic therapy has a shallow tissue penetration depth and has certain harm to normal tissues, and the small molecule chemotherapy drugs have poor targeting and toxic side effects. The present invention aims to synthesize a novel drug delivery platform with high biocompatibility, long circulation time in vivo and synergistic therapy of sonodynamics and chemotherapy

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