3D printing metal base material with polydopamine-mesoporous bioactive glass composite coating as well as preparation method and application of 3D printing metal base material

A bioactive glass, 3D printing technology, applied in coating, metal material coating process, drug delivery, etc., can solve problems such as disadvantage, increased coating surface roughness, uncontrollable reaction, etc., and achieve good biocompatibility , the effect of improving hydrophilicity

Active Publication Date: 2022-06-24
GUANGZHOU INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional self-polymerization method reacts uncontrollably under alkaline conditions, which easily leads to the appearance of aggregated polydopamine particles on Ti, which increases the surface roughness of the coating, which is not conducive to the construction of mesoporous bioactive glass nanospheres with ordered Nanostructured Coatings

Method used

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  • 3D printing metal base material with polydopamine-mesoporous bioactive glass composite coating as well as preparation method and application of 3D printing metal base material
  • 3D printing metal base material with polydopamine-mesoporous bioactive glass composite coating as well as preparation method and application of 3D printing metal base material
  • 3D printing metal base material with polydopamine-mesoporous bioactive glass composite coating as well as preparation method and application of 3D printing metal base material

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Experimental program
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Effect test

Embodiment 1

[0026] This embodiment provides a method for preparing a 3D printed metal substrate with a polydopamine-mesoporous bioactive glass composite coating, including the following steps:

[0027] (1) Pretreatment of 3D printed metal substrates: 1 cm × 2 cm 3D printed titanium sheets were ultrasonically cleaned with acetone, anhydrous ethanol, and deionized water for 15 min, and then the 3D printed Ti sheets were placed in a 40°C oven to dry. 10mL HF, 40mL HNO 3 and 50mL H 2 O is configured as a pickling solution, and the 3D printed Ti sheet is immersed in the pickling solution for 50s. After taking it out, rinse it with absolute ethanol to remove the residual acid solution on the surface, and dry it in an oven for use.

[0028] (2) Preparation of MBG: Add 4g of cetyltrimethylammonium bromide (CTAB) into 220ml of deionized water and 104ml of anhydrous ethanol mixed solution, stir until the solution is clear and transparent, then drop in 10ml of ammonia water, and stir for 30min . ...

Embodiment 2

[0031] This embodiment provides a method for preparing a 3D printed metal substrate with a polydopamine-mesoporous bioactive glass composite coating, including the following steps:

[0032] (1) Pretreatment of 3D printed metal substrates: 1 cm × 2 cm 3D printed titanium sheets were ultrasonically cleaned with acetone, anhydrous ethanol, and deionized water for 15 min, and then the 3D printed Ti sheets were placed in a 40°C oven to dry. 15mL HF, 50mL HNO 3 and 70mL H 2O is configured as a pickling solution, and the 3D printed Ti sheet is immersed in the pickling solution for 40s. After taking it out, it is rinsed with absolute ethanol to remove the residual acid solution on the surface, and it is dried in an oven for use.

[0033] (2) Preparation of MBG: Add 1 g of cetyl trimethyl ammonium bromide (CTAB) to a mixed solution of 220 ml of deionized water and 104 ml of absolute ethanol, stir until the solution is clear and transparent, then drop in 10 ml of ammonia water, and sti...

Embodiment 3

[0036] This embodiment provides a method for preparing a 3D printed metal substrate with a polydopamine-mesoporous bioactive glass composite coating, including the following steps:

[0037] (1) Pretreatment of 3D printed metal substrates: 1 cm × 2 cm 3D printed titanium sheets were ultrasonically cleaned with acetone, anhydrous ethanol, and deionized water for 15 min, and then the 3D printed Ti sheets were placed in a 40°C oven to dry. 5mL HF, 50mL HNO 3 and 75mL H 2 O is configured as a pickling solution, and the 3D printed Ti sheet is immersed in the pickling solution for 40s. After taking it out, it is rinsed with absolute ethanol to remove the residual acid solution on the surface, and it is dried in an oven for use.

[0038] (2) Preparation of MBG: Add 3g of cetyltrimethylammonium bromide (CTAB) to 220ml of deionized water and 104ml of anhydrous ethanol mixed solution, stir until the solution is clear and transparent, drop in 10ml of ammonia water, and stir for 30min . ...

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Abstract

The invention provides a 3D printing metal base material with a polydopamine-mesoporous bioactive glass composite coating and a preparation method and application of the 3D printing metal base material with the polydopamine-mesoporous bioactive glass composite coating, a PDA coating is deposited on the surface of the 3D printing metal base material with the polydopamine-mesoporous bioactive glass composite coating, and MBG nanometer microspheres are doped in the PDA coating. The preparation method comprises the following steps: by taking MBG nano-microspheres and dopamine as raw materials, forming a PDA coating on the surface of a 3D printing metal substrate by adopting an electro-polymerization method, and doping the MBG nano-microspheres into the PDA coating at the same time. The finally obtained base material has a micro-nano structure, biological activity and an organic/inorganic composite coating tightly combined with a base body, the coating has a nano spherical structure, the nano spherical structure is combined with a micron-sized structure on 3D printing Ti, the biomineralization rate of the bone implant can be increased, the hydrophilicity of the 3D printing Ti can be remarkably improved, and the biomineralization rate of the bone implant can be improved. Better biocompatibility is realized.

Description

technical field [0001] The invention belongs to the technical field of bone implant preparation, and in particular relates to a 3D printing metal substrate with a polydopamine-mesoporous bioactive glass composite coating, a preparation method and application thereof. Background technique [0002] 3D printed metal titanium (Ti, Titanium) has an elastic modulus similar to that of bone, excellent corrosion resistance and a micro-rough surface that is conducive to cell adhesion, and has great potential in bone tissue engineering applications. But because Ti is an inert biomaterial, it triggers an immune system response after implantation, and its surface is surrounded by granulation tissue and gradually becomes fibrotic. And this combination of metal implant-fibrous tissue-bone cannot guarantee the long-term use of Ti in the body, so porous Ti must be surface-treated to enhance its biological activity and promote the formation of a good bond between the implant and bone. . At ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/04A61L27/30A61L27/34A61L27/54C23C26/00
CPCA61L27/06A61L27/042A61L27/34A61L27/306A61L27/54C23C26/00A61L2430/02A61L2300/624A61L2300/10A61L2420/04C08L79/04
Inventor 孙学通邸思金建
Owner GUANGZHOU INST OF ADVANCED TECH CHINESE ACAD OF SCI
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