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A kind of preparation method of porous nanofiber membrane

A nanofiber membrane, dry membrane technology, applied in the chemical characteristics of fibers, rayon manufacturing, non-woven fabrics, etc. The effect of good affinity function, good air permeability and moisture permeability, and simple preparation method

Inactive Publication Date: 2018-03-13
YANCHENG SHIBANG TRADE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese Patent Publication No. CN104353127A provides an antibacterial silk protein material and its preparation method. In this invention, graphene quantum dots and silk protein aqueous solution are blended and then solidified and molded. The silk protein material has antibacterial effect, but it is made by solidification molding method The obtained material does not have a porous nanostructure, and the air and moisture permeability of the material is poor, and graphene quantum dots are used and compounded with heavy metal salts containing gold, platinum, lead, ruthenium, etc. The affinity of the material to cells is poor, which cannot be used as Requirements for Wound Covering Materials
Chinese Patent Publication No. CN1887362A discloses a cell culture scaffold and its preparation method. The invention uses electrospinning to compound silk protein and gelatin to prepare a porous nanofiber membrane. The material has good air and moisture permeability The compounding of materials such as gelatin improves the cell affinity of the material, but the material does not have antibacterial properties, so it is limited in the application of materials such as wound dressing

Method used

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  • A kind of preparation method of porous nanofiber membrane
  • A kind of preparation method of porous nanofiber membrane
  • A kind of preparation method of porous nanofiber membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Disperse the cleaned 0.5 g sheet-shaped graphene oxide in 9.5 g anhydrous formic acid, and place it in an ultrasonic oscillator to oscillate for 2 hours to obtain a uniform dispersion of graphene oxide anhydrous formic acid. The mass fraction of graphene oxide in the dispersion is 5%. Add 1.3 g of the regenerated silk protein dry membrane to the above dispersion, and stir for 2 hours with a magnetic stirrer to obtain a uniform spinning solution. The mass fraction of the regenerated silk protein dry membrane in the spinning solution is 11.5%. Adjust the working parameters of the electrostatic spinning device: the voltage is 30kV, the spinning solution flow rate is 0.2mL / h, the distance between the spinneret and the collection device is 13cm, the above spinning solution is added to a 5mL glass syringe, and the spinning solution is electrospun for 2h Afterwards, a porous nanofiber membrane with a thickness of 0.5 mm was obtained on the collection device.

Embodiment 2

[0041] Disperse the cleaned 0.4 g sheet-shaped graphene oxide in 9.5 g of anhydrous formic acid, and place it in an ultrasonic oscillator to oscillate for 2 hours to obtain a uniformly dispersed dispersion of graphene oxide anhydrous formic acid. The mass fraction of graphene oxide in the dispersion is 4%. Add 1.5 g of the regenerated silk protein dry membrane to the above dispersion, and stir for 2 hours with a magnetic stirrer to obtain a uniform spinning solution. The mass fraction of the regenerated silk protein dry membrane in the spinning solution is 13%. Adjust the working parameters of the electrospinning device: the voltage is 20kV, the spinning solution flow rate is 0.3mL / h, the distance between the spinneret and the collection device is 15cm, the above spinning solution is added to a 5mL glass syringe, and the spinning is performed for 2h Then, a porous nanofiber membrane with a thickness of 0.4 mm was obtained on the collection device.

Embodiment 3

[0043] Disperse the cleaned 0.3 g sheet-shaped graphene oxide in 9.5 g of anhydrous formic acid, and place it in an ultrasonic oscillator to oscillate for 2 hours to prepare a uniformly dispersed graphene oxide anhydrous formic acid dispersion. The mass fraction of graphene oxide in the dispersion is 3%. Add 1.2 g of the regenerated silk protein dry membrane to the above dispersion, and stir for 2 hours with a magnetic stirrer to obtain a uniform spinning solution. The mass fraction of the regenerated silk protein dry membrane in the spinning solution is 12%. Adjust the working parameters of the electrospinning device: the voltage is 15kV, the spinning solution flow rate is 0.5mL / h, the distance between the spinneret and the collecting device is 18cm, the above spinning solution is added to a 5mL glass syringe, and the spinning solution is electrospun for 2h Afterwards, a porous nanofiber membrane with a thickness of 0.6 mm was obtained on the collection device.

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Abstract

The invention provides a preparation method of a porous nano fiber membrane. The preparation method comprises the following steps: preparing flake oxide grapheme and a regenerated fibroin dry membrane; dispersing the flake oxide grapheme into an anhydrous formic acid solution, to prepare dispersion liquid; adding the regenerated fibroin dry membrane into the dispersion liquid, to prepare a mixed spinning solution; preparing the porous nano fiber membrane from the mixed spinning solution. The porous fiber membrane prepared by the preparation method disclosed by the invention is high in breathability and moisture-penetrability, good in cell affinity function and better in antibacterial effect; furthermore, the preparation method is simple, and suitable for batch production.

Description

Technical field [0001] The invention relates to a method for preparing a membrane, and more specifically to a method for preparing a porous nanofiber membrane with antibacterial and enhanced cell affinity. Background technique [0002] The main components of silk are sericin and silk fibroin. Silk fibroin, or silk fibroin, is a natural polymer material with abundant output. A large number of domestic and foreign scholars have discovered that the regenerated silk fibroin obtained by degumming, dissolving and purifying silk has good biodegradability and biocompatibility, and is non-toxic, non-irritating, and easy to process into various forms. At present, scholars at home and abroad have been able to prepare fibroin materials into film-like materials, and use these materials in the field of biomedical materials such as wound coating. However, silk protein also has its inherent defects. For example, the silk protein material is not antibacterial, and lacks recognition and induction...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H1/728D04H1/30D01F1/10
CPCD01F1/103D04H1/30D04H1/728
Inventor 王曙东樊理山瞿才新
Owner YANCHENG SHIBANG TRADE
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