Effect of copper wire stem root in preparation of medicine for treating osteoarthritis

Abstract

The invention discloses an effect of copper wire stem root in preparation of a medicine for treating osteoarthritis. According to the invention, chemical components contained in the copper wire stem root are separated and represented, and it is found for the first time that the copper wire stem root contains various anti-osteoarthritis active components, including 6-hydroxy-2-isopropyl-7-methyl-1, 4-naphthoquinone, protocatechualdehyde, (E)-3, 3, 4, 5, 6-tetramethyl-1, 3, 4, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, 5-tetramethyl-1, 3, the compound is prepared from 2, 4-dihydroxybenzylidene acetone, 3-chloro-4-hydroxy-benzoic acid, kaempferol-3-O-rutinoside, p-hydroxymethylene benzyl acetone and the like. According to the application disclosed by the invention, the (E)-3, 4-dihydroxybenzylidene acetone, the 3-chloro-4-hydroxy-benzoic acid and the p-hydroxymethylene benzyl acetone are found for the first time, so that not only can the content of MMP-13 in a cartilage cell culture supernatant be remarkably reduced, but also the survival rate of the cartilage cells after IL-1beta intervention can be remarkably improved; therefore, the copper wire stem root and the three compounds can be used for preparing the medicine for treating osteoarthritis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the effect of copper wire rattan root in the preparation of a drug for treating osteoarthritis. Background technique [0002] The main manifestation of osteoarthritis is the inflammatory reaction of the body or the bones and joints. At present, there is no cure for arthritis. Most of them use non-steroidal anti-inflammatory drugs or glucocorticoids to alleviate the symptoms. The treatment of such diseases needs to be further developed. development. [0003] Copper wire rattan root is a traditional medicinal material of the She nationality. It is the dry root and rhizome of Lygodium japonicum (Thunb.) Sw., which is now included in the 2015 edition of "Zhejiang Province Traditional Chinese Medicine Processing Specifications", also known as iron centipede , wire grass, iron footed centipede root, sea sand root. Its properties are sweet, light, cold, non-toxic, and h...

AI Technical Summary

Problems solved by technology

[0004] At present, there are few studies on the chemical components and pharmacological effects of copper vine root, so there is no report on the use of copper vine root for the treatment of osteoarthritis

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