Ozone composition and preparation method thereof, and method for preparing glyoxylic acid through reactive distillation

Abstract

The invention discloses an ozone composition and a preparation method thereof, and a method for preparing glyoxylic acid through reactive distillation. An oxygen source containing a certain concentration of carbon dioxide and nitrogen is used for preparing ozone in an ozone generator. A trace amount of nitrogen and carbon dioxide are compounded, so that ozonolysis can be inhibited, and the efficiency of the ozone generator is improved. A maleic acid aqueous solution and ozone gas are subjected to countercurrent contact in a reactive distillation column for reaction, a formic acid-water mixed solution is extracted from the top of the column, and a glyoxylic acid solution is obtained from the bottom of the column. The contact time of glyoxylic acid and oxygen is short, so that deep oxidation is less, and the yield is high; water is adopted as a solvent, the reaction temperature is increased, the tail gas formic acid concentration is properly increased to be smaller than or equal to 2%, the tolerance range is wider, it is still guaranteed that the formic acid content is far lower than the explosion limit, technological operation is safer, and energy conservation and consumption reduction are achieved.

Description

technical field [0001] The invention relates to the field of gas preparation and organic synthesis, in particular to a method for preparing glyoxylic acid by reactive distillation of ozone preparation. Background technique [0002] As an important organic chemical intermediate raw material, glyoxylic acid, ethyl vanillin made from glyoxylic acid, is widely used in the fragrance and fixative of cosmetics, the essence of daily chemicals, and the fragrance of food. . Allantoin made from glyoxylic acid. It is used as a good healing agent for skin wounds, an additive for high-end cosmetics, and a plant growth regulator. In medicine, glyoxylic acid is used for the preparation of p-hydroxyphenylglycine (the raw material for amoxicillin and cephalosporin), p-hydroxyphenylacetamide (for the manufacture of an effective substance for the treatment of cardiovascular disease and hypertension - Atel) , as well as pharmaceutical products such as p-hydroxyphenylacetic acid and p-hydroxyb...

AI Technical Summary

Problems solved by technology

[0011] (1) Reaction intermittent oxidation process, low reaction efficiency;

[0012] (2) The reaction uses organic solvents such as methanol, which has a low flash point and a high risk of explosion, which does not meet the design principles of intrinsic safety;

[0013] (3) The reaction uses a large amount of chilled water to remove a large amount of heat generated, which leads to high energy consumption and high cost;

[0014] (4) The reaction liquid generated by the reaction requires secondary separation, which consumes a large amount of steam and cooling water

There are difficult problems in the existing production processes, so there is an urgent need for a more green and efficient solution

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