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Lipopeptide chain and Fab-aliphatic chain conjugate

A technology of aliphatic chains and conjugates, applied in the fields of peptides, drug combinations, allergic diseases, etc., can solve problems such as complex modification process, reduced protein activity, and difficult separation of modified products, achieving high reaction efficiency, extended half-life, and avoidance of The effect of the product heterogeneity problem

Pending Publication Date: 2022-07-19
CHIA TAI TIANQING PHARMA GRP CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the long-acting strategy based on PEG modification technology has problems such as complicated modification process, difficult separation of modified products, and reduced protein activity after modification.

Method used

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  • Lipopeptide chain and Fab-aliphatic chain conjugate
  • Lipopeptide chain and Fab-aliphatic chain conjugate
  • Lipopeptide chain and Fab-aliphatic chain conjugate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0122] Embodiment [1]: a lipopeptide chain, characterized in that the lipopeptide chain has the structural formula shown in formula 1, formula 2 or formula 3:

[0123]

[0124] Wherein, -NH-Xaa-CO- is D-alanine residue, β-alanine residue, 4-aminobutyric acid residue, 2-aminoisobutyric acid residue, 2-aminobutyric acid residue , arginine residues, aspartic acid residues, asparagine residues, cysteine ​​residues, glutamic acid residues, D-glutamic acid residues, γ-glutamic acid residues, glutamic acid residues Aminoamide residues, glycine residues, histidine residues, isoleucine residues, leucine residues, lysine residues, proline residues, phenylalanine residues, serine residues , a tyrosine residue, a threonine residue, a tryptophan residue, a valine residue or a methionine residue or one or the absence thereof,

[0125] a is 0, 1, 2, 3, 4, or 5,

[0126] b is 0, 1, 2, 3, 4 or 5,

[0127] c is 1, 2, 3, 4 or 5,

[0128] R 1 for C 6-20 aliphatic straight-chain or branch...

Embodiment approach 2

[0131] Embodiment [2]: The lipopeptide chain according to Embodiment [1], wherein the -NH-Xaa-CO- is a 4-aminobutyric acid residue, a 2-aminoisobutyric acid residue, D-alanine residues, β-alanine residues, aspartic acid residues, cysteine ​​residues, glutamic acid residues, γ-glutamic acid residues, glycine residues, serine residues One or the absence of a tyrosine residue or a tyrosine residue.

Embodiment approach 3

[0132] Embodiment [3]: The lipopeptide chain according to Embodiment [1] or [2], wherein the a is 1, 2 or 3, preferably 2.

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Abstract

The invention provides a fat peptide chain and Fab fragment analogue, and also provides a Fab-fat chain conjugate as well as a preparation method and application thereof. According to the invention, a fat peptide chain is subjected to site-specific modification on a Fab fragment through SortaseA enzyme, such that the Fab-fat chain conjugate is obtained. The Fab-aliphatic chain conjugate disclosed by the invention retains an antigen binding effect of Fab fragment specificity and has albumin binding capacity, and the half-life period in vivo is prolonged.

Description

technical field [0001] The invention belongs to the field of biotechnology, in particular to the field of long-acting biological drug development, and in particular to a class of lipopeptide chains, Fab-fatty chain conjugates and Fab fragment analogs, and preparations by using lipopeptide chains and Fab fragment analogs Methods of Fab-aliphatic chain conjugates and applications of Fab-aliphatic chain conjugates. Background technique [0002] Autoimmune disease refers to abnormal immunity of the body, the immune system attacks self-antigens, and ultimately mediates tissue inflammation and damage. Among them, inflammatory diseases such as rheumatoid arthritis (RA), Crohn's disease (CD), and ankylosing spondylitis (AS) are all autoimmune diseases. Studies have shown that these inflammatory diseases have the same pathogenesis. As a pro-inflammatory factor, TNF-α (tumornecrosis factor α, tumor necrosis factor α) plays a key role in the pathological process of RA, CD, AS and othe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/083C07K7/06A61K39/395A61K47/64A61P35/00A61P37/02
CPCC07K5/0806C07K7/06C07K16/241A61K47/64A61P35/00A61P37/02C07K2317/56C07K2317/565C07K2317/55C07K2317/92A61K2039/505
Inventor 冯军张庆彬张喜全东圆珍赵文杰赵伟徐宏江钱梦歆张金华
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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