Novel allyl hydroximic acid derivative containing sulfonate structure as well as preparation method and application of novel allyl hydroximic acid derivative
A technology of propenyl hydroxamic acid and sulfonate ester, which is applied in the direction of sulfonate ester preparation, drug combination, organic chemistry, etc., to achieve the effect of improving biological activity
Pending Publication Date: 2022-07-22
NANJING UNIV
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The invention discloses a benzene propenyl hydroximic acid derivative containing a sulfonate structure as well as a preparation method and application of the benzene propenyl hydroximic acid derivative. According to the source and the effect in spartina alterniflora resource utilization, the spartina alterniflora is named as spartina alterniflora G series. The structural formula of the benzene allyl hydroximic acid derivative containing the sulfonate structure is shown as a formula (I), wherein R1 is selected from-H or C1-C6 alkoxy, and R2 is selected from C1-C6 alkyl and substituted or non-substituted phenyl. The compound provided by the invention has xanthine oxidase inhibitory activity, and can be used for preparing drugs for treating and/or preventing hyperuricemia. The upstream preparation raw materials p-coumaric acid and ferulic acid of the compound can be obtained by a natural extraction method, and resource utilization of spartina alterniflora can be realized.
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