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Photo-thermal antibacterial medical injectable hydrogel and preparation method thereof

A water injection, photothermal technology, applied in medical science, resistance to vector-borne diseases, bandages, etc., can solve the problems of non-water solubility, increase the difficulty of clinical application, etc., achieve uniform dispersion and stable load, and achieve long-term release. , the effect of accelerating wound healing

Active Publication Date: 2022-08-02
BEOGENE BIOTECH GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its strong antibacterial effect, less damage to normal tissues, and certain penetration depth, photothermal therapy provides a new way for the development of wound antibacterial dressings, but few existing photosensitizers can be used as drugs. Carriers, while delivering therapeutic drugs, can only play the role of photothermal conversion
[0005] In addition, for the inflammatory response disorder in the process of wound healing, some studies have used anti-oxidative drugs, such as resveratrol, tea extracts, etc. to clear free radicals in the wound, but these drugs usually do not have a good effect. Water solubility increases the difficulty of clinical application

Method used

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  • Photo-thermal antibacterial medical injectable hydrogel and preparation method thereof
  • Photo-thermal antibacterial medical injectable hydrogel and preparation method thereof
  • Photo-thermal antibacterial medical injectable hydrogel and preparation method thereof

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Embodiment 1

[0035]Embodiment 1 of the present invention provides a photothermal antibacterial medical injectable hydrogel, which includes hollow bismuth nanospheres loaded with aminolevulinic acid hydrochloride, methacrylated gelatin, oxidized dextran, gelatin, photoinitiated agent and an aqueous medium, wherein the aminolevulinate hydrochloride and the hollow bismuth nanospheres in the hollow bismuth nanospheres loaded with aminolevulinate hydrochloride are loaded according to a weight ratio of 2:1, and the photoinduced The agent is lithium phenyl-2,4,6-trimethylbenzoylphosphonate, and the aqueous medium is deionized water.

Embodiment 2

[0037] Embodiment 2 of the present invention provides a photothermal antibacterial medical injectable hydrogel, which comprises hollow bismuth nanospheres loaded with aminolevulinic acid hydrochloride, methacrylated gelatin, oxidized dextran, gelatin, photoinitiated agent and an aqueous medium, wherein aminolevulinate hydrochloride and hollow bismuth nanospheres in the hollow bismuth nanospheres loaded with aminolevulinate hydrochloride are loaded according to a weight ratio of 3:1, and the photoinduced The agent is lithium phenyl-2,4,6-trimethylbenzoylphosphonate, and the aqueous medium is phosphate buffered saline (PBS).

Embodiment 3

[0039] Embodiment 3 of the present invention provides a method for preparing a photothermal antibacterial medical injectable hydrogel, which comprises the following specific operation steps:

[0040] 1) Preparation of hollow bismuth nanospheres: 0.148g of bismuth nitrate was weighed and dissolved in 5mL of nitric acid solution, and 0.15g of polyvinylpyrrolidone and 25mL of ethylene glycol were added to the above solution, wherein the average molecular weight of the polyvinylpyrrolidone was 10000; then the mixed solution was transferred to a hydrothermal kettle and reacted at 180°C for 12 h; the reaction solution was centrifuged to collect the precipitate, washed with deionized water for several times, and dried to obtain the hollow bismuth nanospheres. The particle size of the bismuth nanospheres measured by dynamic light scattering (DLS) is 500-600 nm;

[0041] 2) Loading of aminolevulinic acid hydrochloride: Weigh 6 mg of aminolevulinic acid hydrochloride and 2 mg of the hol...

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Abstract

The invention relates to a photo-thermal antibacterial medical injectable hydrogel and a preparation method thereof, the photo-thermal antibacterial medical injectable hydrogel comprises hollow bismuth nanospheres loaded with aminolevulinate hydrochloride, methacrylated gelatin, oxidized dextran, gelatin, a photoinitiator and an aqueous medium, the hydrogel has the advantages of being injectable and rapid in curing, and by means of cross-linking after injection, complete sealing of irregular wounds is achieved, the moist environment of the wounds is maintained, and healing of the wounds is accelerated. Besides, the aminolevulinate hydrochloride is loaded in the cavities of the hollow bismuth nanospheres, the aminolevulinate hydrochloride is used for realizing an immune regulation function, and the bismuth nanomaterial has a photo-thermal sterilization effect, so that the wound infection problem can be effectively solved, and the bismuth nanomaterial can also be used as a slow-release carrier material to realize long-term release of the aminolevulinate hydrochloride; the problems that in the prior art, a nano-antibacterial solution and the like are used for treating the wound surface, multiple times of drug administration is needed, and the treatment process is complex are solved.

Description

technical field [0001] The invention relates to the technical field of medical biological materials, in particular to a photothermal antibacterial medical injectable hydrogel and a preparation method thereof. Background technique [0002] Modern medical nursing methods for difficult-to-heal wounds mainly include surgical debridement, negative pressure drainage, etc. However, these technical methods can only promote wound healing to a small extent, and patients still face a large economic burden and the torment of skin ulceration, which seriously affects patient quality of life. In addition, for some wounds that have been infected for a long time, festering and unhealed for a long time, severe cases may face the risk of amputation. Existing treatment methods are still difficult to achieve satisfactory therapeutic effects for these conditions. [0003] After years of research on the mechanism of wound healing, researchers have found that the reasons for the difficulty in wou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J3/075C08J3/24C08L89/00C08L5/02
CPCA61L26/008A61L26/0061A61L26/0066A61L26/0038A61L26/0023A61L26/0004C08J3/075C08J3/24A61L2400/06A61L2300/102A61L2300/41A61L2300/404A61L2300/45A61L2300/204A61L2400/12C08J2305/02C08J2489/00C08L5/02Y02A50/30
Inventor 刘慧玲郭瑞
Owner BEOGENE BIOTECH GUANGZHOU
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