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Nanofiber dressing and preparation method thereof

A nanofiber and nanofiber membrane technology, applied in the field of biomedical materials, can solve problems such as unclear mechanism of action, pharmacological toxicity, and inability to assess safety, and achieve the effects of avoiding side effects, obvious healing effect, and reducing usage.

Active Publication Date: 2022-08-05
诺一迈尔(苏州)生命科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many drug ingredients commonly used to accelerate the treatment of skin wounds, such as bioglass, cork liquid, etc., but these drugs are mixtures, and the mechanism of action is not clear. They act directly on the wound, and may have pharmacological toxicity and safety cannot be evaluated.

Method used

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  • Nanofiber dressing and preparation method thereof
  • Nanofiber dressing and preparation method thereof
  • Nanofiber dressing and preparation method thereof

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preparation example Construction

[0028] In order to obtain a non-toxic dressing to accelerate wound healing, the present invention provides a preparation method of a nanofiber dressing, the preparation method comprising the following steps:

[0029] S1: Based on amino acid peptidation reaction, synthesis of short peptides for recruiting endogenous VEGF;

[0030] S2: Dissolve the short peptide, degradable polymer material, and natural polymer material in a solvent, and mix evenly to obtain an electrospinning solution;

[0031] S3: electrospinning the electrospinning solution by electrospinning technology to obtain an electrospinning nanofiber membrane;

[0032] S4: drying and cutting the electrospun nanofiber membrane to obtain a nanofiber dressing.

[0033] VEGF (vascular endothelial growth factor) has the effect of promoting increased vascular permeability, vascular endothelial cell migration, proliferation and angiogenesis; the present application introduces a short peptide for recruiting endogenous VEGF i...

Embodiment 1

[0051] The present embodiment provides a preparation method of a nanofiber dressing, the preparation method comprising the following steps:

[0052] S1: Preparation of short peptide PR1P: According to the set amino acid sequence, the amino acid sequence of short peptide PR1P is synthesized by amino acid peptide-forming reaction, and then the short peptide PR1P powder is obtained by further purification, drying and other processes;

[0053] S2: Preparation of short peptide PR1P spinning solution: take 1 mg of short peptide PR1P powder, dissolve it in 10 mL of HFIP (>99%, Shanghai Darui Chemical Co., Ltd.) reagent (short peptide PR1P concentration 0.01 mg / mL), measure 20 μL of short peptide PR1P solution with a concentration of 0.01 mg / mL was transferred into 19.88 mL of HFIP solution, and 2 g of PLGA (molar ratio 75:25, Jinan Daigang Bioengineering Co., Ltd.) / Gel (molecular weight) was further added to 20 mL of HFIP solution. >8000, MP Biomedicals, LLC) (w:w=7 / 3) mixture, the H...

Embodiment 2

[0058] The present embodiment provides a preparation method of a nanofiber dressing, the preparation method comprising the following steps:

[0059] S1: Preparation of short peptide PR1P: According to the set amino acid sequence, the amino acid sequence of short peptide PR1P is synthesized by amino acid peptide-forming reaction, and then the short peptide PR1P powder is obtained by further purification, drying and other processes;

[0060] S2: Preparation of short peptide PR1P spinning solution: take 1 mg of short peptide PR1P powder, dissolve it in 10 mL of HFIP (>99%, Shanghai Darui Chemical Co., Ltd.) reagent (short peptide PR1P concentration 0.01 mg / mL), measure 200 μL of short peptide PR1P solution with a concentration of 0.01 mg / mL was transferred into 19.88 mL of HFIP solution, and 2 g of PLGA (molar ratio 75:25, Jinan Daigang Bioengineering Co., Ltd.) / Gel (molecular weight) was further added to 20 mL of HFIP solution. >8000, MP Biomedicals, LLC) (w:w=7 / 3) mixture, the ...

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Abstract

The invention provides a nanofiber dressing and a preparation method thereof, and relates to the technical field of biomedical materials.The preparation method comprises the following steps that on the basis of amino acid peptide forming reaction, oligopeptide for collecting endogenous VEGF is synthesized; dissolving the oligopeptide, a degradable high polymer material and a natural high polymer material in a solvent, and uniformly mixing to obtain an electrostatic spinning solution; carrying out electrostatic spinning on the electrostatic spinning solution by utilizing an electrostatic spinning technology to obtain an electrostatic spinning nanofiber membrane; the electrostatic spinning nanofiber membrane is dried and cut, and the nanofiber dressing is obtained. According to the preparation method of the nanofiber dressing provided by the invention, by utilizing the VEGF collecting performance of the oligopeptide, the repair of tissues needing revascularization can be remarkably promoted, and the healing effect on skin wounds and abnormal body diabetes wounds is obvious; meanwhile, the oligopeptide can be safely degraded in an organism, and a degradation product is amino acid and has no toxic effect on the organism.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a nanofiber dressing and a preparation method thereof. Background technique [0002] Skin trauma refers to a common tissue injury caused by an uncontrollable external force, resulting in severing or defecting of the skin tissue. After skin trauma, the body generally has a spontaneous healing process, including the regeneration of various tissues, the proliferation of granulation tissue, and the formation of scar tissue. However, when the skin tissue is excessively damaged or the abnormal body (such as diabetes and other chronic healing patients) has skin damage, the body's spontaneous healing rate cannot repair the wound in time, which may lead to complications such as wound infection and increased tissue inflammation. Based on severe trauma patients and chronic healing patients such as diabetes, it is necessary to provide a safe and highly feasible wound dressing s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/26A61L15/42A61L15/32D04H1/728D01D5/00
CPCA61L15/44A61L15/26A61L15/42A61L15/325A61L15/32D04H1/728D01D5/003A61L2400/12A61L2300/414C08L67/04C08L89/00Y02A50/30
Inventor 莫秀梅潘信袁征超穆罕默德·沙菲克吴凡
Owner 诺一迈尔(苏州)生命科技有限公司
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