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Recombination alpha-interferon gelatin injection

A gel propellant, interferon technology, applied in the direction of antiviral agents, drug combinations, peptide/protein components, etc., can solve the problems of inconvenient vaginal medication, dissolving exudates and contaminating clothes, etc., achieving no negative effects, Safe to use and simple to process

Inactive Publication Date: 2004-12-15
SHENYANG SUNSHINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the interferon preparations that have been marketed for the treatment of gynecological viral inflammation are suppositories, using gelatin-glycerin base or fat-soluble base, which is not very convenient for vaginal administration, and the dissolved effluent contaminates clothes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Ingredient content (weight%)

[0025] Carbomer 934 0.5%

[0026] 10% Sodium Hydroxide 2%

[0027] Methylparaben 0.2%

[0028] Recombinant Human Alpha Interferon 333,000 IU / g

[0029] Water make up 100%

[0030] Take water, add methyl p-hydroxybenzoate, add carbomer after dissolving, add sodium hydroxide solution after dissolving, neutralize, and form a gel. Add recombinant human α-interferon, mix well, and fill in a syringe.

Embodiment 2

[0032] Ingredient content (weight%)

[0033] Carbomer 934 0.5%

[0034] 10% Sodium Hydroxide 2%

[0035] Methylparaben 0.18%

[0036] Propylparaben 0.02%

[0037] Glycerin 10%

[0038] Disodium edetate 0.02%

[0039] Recombinant Human Alpha Interferon 10,000 IU / g

[0040] Water make up 100%

[0041] Take water, add glycerin, add methyl p-hydroxybenzoate and propyl p-hydroxybenzoate after dissolving, add disodium edetate after dissolving, add carbomer after dissolving, add sodium hydroxide solution after dissolving, and, to form a gel. Add recombinant human α-interferon, mix well, and fill in a syringe.

Embodiment 3

[0043] Ingredient content (weight%)

[0044] Carbomer 940 0.5%

[0045] 10% Sodium Hydroxide 2%

[0046] Methylparaben 0.2%

[0047] Ethanol 10%

[0048] Sodium thiosulfate 0.02%

[0049] Recombinant Human Alpha Interferon 100,000 IU / g

[0050] Water make up 100%

[0051] Take water, add ethanol, add methyl p-hydroxybenzoate after dissolving, add sodium thiosulfate after dissolving, add carbomer after dissolving, add sodium hydroxide solution after dissolving, neutralize, and form a gel. Add recombinant human α-interferon, mix well, and fill in a syringe.

[0052] The recombinant human alpha interferon of the above-mentioned example 1-3 is stable at 2~8°C,

[0053] See the table below for details:

[0054] Interferon activity (×10 5 IU / g)

[0055] Conclusion: The interferon activity remains unchanged within 15 months of storage at 2-8°C; the long-term investigation is still in progress.

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PUM

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Abstract

A recombinant human alpha interferon gel propellant for the treatment of female viral vaginal diseases, the technical gist of which is to contain a certain amount of the following ingredients: recombinant human alpha interferon as the active ingredient, gel matrix carbomer, preservatives incompatible with interferon, sodium hydroxide or triethanolamine as carbomer resin neutralizer; the balance is water. It is characterized in that the recombinant human α-interferon is prepared into a stable water-soluble gel, filled in a disposable injector, and prepared as a recombinant human α-interferon gel propellant for viral gynecological inflammation. It has the characteristics of safe, convenient, non-irritating and non-polluting clothing. The invention also has the advantages of simple production process, long storage period, convenient use and no side effects.

Description

technical field [0001] The invention relates to a recombinant human alpha interferon gel propellant for treating gynecological diseases. Interferon is an important cell activity factor, which has biological activities such as anti-virus, immune regulation, hormone-like activity, and anti-tumor. Clinically, it has been widely used in antiviral infection, treatment of tumors and activation of immune cells to play an immune mediation role. Background technique [0002] Chronic cervicitis (cervical erosion) caused by herpes simplex virus and human papillomavirus is a common disease in gynecology, and it is the most common inflammation of the female reproductive system. At present, the interferon preparations that have been marketed for the treatment of gynecological viral inflammation are suppositories, which use gelatin-glycerin base or fat-soluble base, which is not very convenient for vaginal administration, and the dissolved effluent contaminates clothes. Using gelatin-gly...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K38/21A61P15/02A61P31/12
Inventor 赵会林侯绪凤苏冬梅
Owner SHENYANG SUNSHINE PHARMA
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