Anticarcinogen composition

A technology of anticancer drugs and compositions, applied in the direction of drug combinations, antineoplastic drugs, anhydride/acid/halide active ingredients, etc., can solve the problems of inability to dilate blood vessels, coronary artery theft, etc., achieve high curative effect, convenient medication, The effect of broad-spectrum anticancer activity

Inactive Publication Date: 2007-05-16
刘国廉
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, it is not used in clinical practice at present. The reason is that this product mainly expands the small resistance blood vessels of the coronary arteries, and the blood vessels in the myocardial ischemic area have been compensatoryly expanded to maintain their maximum blood supply. Therefore, this product is used Not only can it not expand the blood vessels in the ischemic area and improve its blood supply, but it will make the blood in the ischemic area flow to the non-ischemic area, which is the so-called "coronary artery stealing" phenomenon.

Method used

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  • Anticarcinogen composition
  • Anticarcinogen composition
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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1, adjuvant, granulation condition and the impact of packaging on Depa Kaluo (Dipycaro)

[0016] 1. Screening of excipients

[0017] It is reported in the literature that β-carotene is easily oxidized when exposed to oxygen, so it should be stored airtight in the refrigerator (4°C); DP is relatively stable in nature, but it is also easy to decompose under high heat conditions. The amount of the two ingredients in Depacalol is not large, and most of them need to be filled with auxiliary materials.

[0018] The contriver has selected β-CD, starch, dextrin, microcrystalline cellulose to mix respectively with principal agent, under the situation of strong light (4900LX), high temperature (60 ℃), high humidity (humidity 92%), investigate the effect of auxiliary materials on The effect of the main drug.

[0019] The steps are as follows: Weigh 2.5g of DP, 5g of 10% β-carotene dry powder, and 17.5g of auxiliary materials, a total of 25g, mix well, divide into 3 pa...

Embodiment 2

[0034] Embodiment 2, the preparation of Pakaluo (Dipycaro) capsule

[0035] Capsule Formulation:

[0036] DP 25g

[0037] 10% βC 50g

[0038] Starch 150g

[0039] Made into 1000 capsules, 225mg each.

[0040] The capsule preparation process flow chart is as shown in Figure 1, and specifically includes the following steps:

[0041] (1) drying the starch at 80°C-90°C to a water content of 3%-5% for later use;

[0042] (2) Mix the above-mentioned crude drug with the dried starch, stir thoroughly until the mixed drug powder is orange-red, and take it out;

[0043] (3) Carry out dry granulation with the above-mentioned mixed medicinal powder;

[0044] (4) capsule filling, polishing;

[0045] (5) Double aluminum outer packaging is ready.

Embodiment 3

[0046] Embodiment 3, the antitumor effect of Pacarol (Dipycaro)

[0047] 1. In vitro cell experiments

[0048] Human lung cancer cells (A549), human liver cancer cells (BEL-7402), human gastric cancer cells (BCK-823) and human leukemia (HL60) four cells were selected, and the single prescription, the compound prescription and the positive control drug (fluridine) were respectively tested against Tests on the above tumor strains.

[0049] Dipyridamole was prepared with 0.1N hydrochloric acid (HCl), β-carotene was prepared with 20% dimethyl sulfoxide (DMSO), and Pacalol and fluridine solutions were prepared with normal saline. with RPMI-1640 medium in 5% CO 2 Cultivate human lung cancer cells, human liver cancer cells, and human gastric cancer cells under static conditions in an incubator at 37°C. After culturing for 24-36 hours, inoculate them into cell culture plates, and add the above solution to the cell culture plates to make the concentration of DP in the culture system ...

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Abstract

A composite anticancer medicine with 10w poison, high curative effect and broad spectrum contains dipyridamole and beta-carotene.

Description

technical field [0001] The invention relates to an anticancer drug composition. Background technique [0002] Tumor has become one of the major diseases that seriously threaten human survival and health, and its morbidity and mortality are on the rise. [0003] Dipyridamole (DP) is a non-nitrate coronary artery dilator, mainly used for coronary insufficiency, or the prevention and treatment of angina pectoris and myocardial infarction, the molecular formula is C 24 h 10 N 8 o 4 , the molecular weight is 504.65, and the structural formula is shown in the formula (I), which has been loaded into the Chinese Pharmacopoeia (2000 edition) and the United States Pharmacopoeia (XXI-XXIII). However, it is not used in clinical practice at present. The reason is that this product mainly expands the small resistance blood vessels of the coronary arteries, and the blood vessels in the myocardial ischemic area have been compensatoryly expanded to maintain their maximum blood supply. Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61P35/00A61K31/557
Inventor 刘国廉周淑珍
Owner 刘国廉
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