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Biological degradable injectable bracket of modified hydrogel for use in cartilage tissue engineering

A technology of biodegradation and cartilage tissue, applied in the field of biomedical engineering materials, can solve the problems of donor site deformity and infection, less donor tissue, and difficulty in achieving satisfactory results, and achieve fast gelation, strong water retention, and gelation The effect of excellent mechanical properties

Inactive Publication Date: 2004-10-27
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Autologous transplantation has disadvantages such as less donor tissue, postoperative deformity and infection of the donor site, and allogeneic cartilage transplantation has not yet resolved the contradiction between chondrocyte activity and immunogenicity, and both are difficult to achieve satisfactory results

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 1 gram of polyethylene glycol dimethacrylate (PEGDMA) with an average molecular weight of 330, 0.125 gram of N-vinylpyrrolidone (NVP), 1 mg of ammonium persulfate, 70 mg of sodium sulfite, and 1 gram of deionized water in a beaker Prepare the solution, and react in a constant temperature water bath at 50°C for 15 minutes to obtain a gel of unsuspended chondrocytes.

Embodiment 2

[0024] Take 1 gram of polyethylene glycol dimethacrylate (PEGDMA) with an average molecular weight of 550, 2 grams of N-vinylpyrrolidone (NVP), 8 mg of potassium persulfate, 4 mg of sodium bisulfite, and 2 grams of deionized water. The solution was prepared in a beaker, and then reacted in a constant temperature water bath at 40°C for 30 minutes to obtain a gel of unsuspended chondrocytes.

Embodiment 3

[0026] Take 1 gram of polyethylene glycol dimethacrylate (PEGDMA) with an average molecular weight of 875, 8 grams of N-vinylpyrrolidone (NVP), 30 mg of ammonium persulfate, 10 milliliters of absolute ethanol, and 10 grams of deionized water in The solution was prepared in a beaker, and then reacted in a constant temperature water bath at 30°C for 45 minutes to obtain a gel of unsuspended chondrocytes.

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PUM

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Abstract

A biodegradable modified aqueogel scaffold able to be injected to chondrotissue engineering is prepared from water-soluble redox triggering system, deionized water, and two biocompatible polymers through proportionally mixing, and reaction in constant-temp water bath. Its advantages are high gelatinizing speed, high gel strength and water-preserving power and high degradation speed.

Description

technical field [0001] The invention belongs to the field of biomedical engineering materials, in particular to a biodegradable injectable modified hydrogel support for cartilage tissue engineering. Background technique [0002] Cartilage is a kind of tissue with poor regenerative ability. The repair of cartilage defect caused by trauma and other reasons is a difficult problem in clinical medicine. At present, autograft or allograft is mainly used to repair it. Autologous transplantation has disadvantages such as less donor tissue, and it is easy to cause deformity and infection of the donor site after operation. However, allogeneic cartilage transplantation has not yet resolved the contradiction between chondrocyte activity and immunogenicity, and both are difficult to achieve satisfactory results. Since the creation of tissue culture technology in 1907, repairing tissue defects with tissue cell transplantation has provided a new method to solve this problem. Scaffold mate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/56A61F2/28A61K38/00A61L27/00A61L27/50
Inventor 胡平许波
Owner TSINGHUA UNIV