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Combination of Chinese traditional medicine for curing disease of respiratory system and preparing method

A technology for respiratory diseases and compositions, applied in respiratory diseases, drug combinations, pharmaceutical formulas, etc., can solve problems such as the difficulty of extraction and separation, the formulation of drug quality standards and the difficulty of quality control

Inactive Publication Date: 2004-10-27
任秀云
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the extremely low content of isofaskolin in the medicinal material (0.05%), and the difficulty of extraction and separation, coupled with the high activity and small dose, it is very difficult to formulate drug quality standards and control the quality.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Scented compound microcapsule dry powder inhaler

[0018] Formula (1000 doses):

[0019] Laudanane-type diterpenoids (80%) 0.15g

[0020] Mugwort Oil 1ml

[0021] Cinnamon oil 1.5ml

[0022] Panax notoginseng 5.5g

[0023] Ethyl cellulose 20g

[0024] PVA 6g

[0025] magnolia oil amount

[0026] Preparation Process:

[0027] Under the condition of 100,000 grades, dissolve the prescribed amount of drugs and excipients in 600ml of ethyl cellulose and PVA isopropanol solution, select the inlet temperature at 70°C to 90°C, and the outlet temperature at 45°C to 65°C . Choose a gas-material-airflow spray dryer, and control the slow sampling speed, so that the particle size of the product can reach a diameter of less than 10 μm, and the compound microcapsules with fragrance can be obtained after spray drying. The microcapsules are uniformly mixed with an appropriate amount of superfine mannitol and other fillers, and encapsulated in a capsule (or blister-typ...

Embodiment 2

[0028] Embodiment 2 compound soft capsule

[0029] Prescription (1000 capsules):

[0030] Laudanane-type diterpenoids (40%) 0.2g

[0031] Mugwort Oil 2ml

[0032] Cinnamon Oil 4ml

[0033] Panax notoginseng saponins 15g

[0034] soybean oil 400g

[0035] The processing process of the compound soft capsule is as follows: after mixing the raw materials according to the required ratio, ultra-fine treatment such as jet milling or ball milling is used to achieve a particle size of less than 200 μm, and the ultra-fine compound drug is added to the solvent matrix, fully Stir, dissolve, filter, degas, and send to the tank above the filling machine for use; at the same time, prepare the gelatin solution for the rubber in the thermal insulation gelatin tank above the soft capsule filling machine for use; ~25°C, RH%: 39~41%, start the rotary molding machine to press pellets, wash the soft capsules, dry at 28±2°C for 19~27 hours, subpackage and pack to get the finished product .

Embodiment 3

[0036] Embodiment 3 scented compound microcapsules

[0037] formula:

[0038] Laudanane-type diterpenoids (10%) 0.4g

[0039] Mugwort Oil 10ml

[0040] Cinnamon Oil 29ml

[0041] Panax notoginseng saponins 120g

[0042] Ethyl cellulose 4000g

[0043] PVA 1000g

[0044] Orange spice amount

[0045] Preparation Process:

[0046]Under the condition of 100,000 grades, dissolve the original medicine and orange flavor of the formula in 900ml of ethyl cellulose and PVA isopropanol solution, choose the inlet temperature at 70°C~85°C, and the outlet temperature at 45°C~ 60°C. After spray drying, the compound microcapsules with orange flavor can be obtained. The microcapsules can be directly compressed into tablets or capsules.

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PUM

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Abstract

A Chinese medicine for treating the diseases in respiratory system, such as allergic rhinitis, asthma, branchitis, etc is prepared from 4 Chinese-medicinal materials including felon herb, cinnamon bark, notoginseng, etc.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine composition for treating respiratory diseases and a preparation method thereof. Background technique [0002] In the 1970s, German and Indian scholars collected Coleus Forskohlii from Mumbai, India, and isolated from it the highly active Laudanane diterpene compound - Forskolin (forkolin) and its analogous compounds. Pharmacological studies have confirmed that forskolin is the strongest adenylyl cyclase activator known so far. It does not inhibit phosphodiesterase, but directly increases the concentration of cAMP in cells to produce physiological activity. 10 -9 g / ml is active. Since this type of compound exhibits obvious antihypertensive and cardiotonic activities, it has remarkable curative effects in the treatment of cardiovascular diseases, congestive heart failure, tumor metastasis, bronchial asthma, skin diseases, etc., and has a good development prospect. After knowing this information ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61M37/00A61P11/00
Inventor 任秀云
Owner 任秀云
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