Process for extracting polygonatum polysaccharides, preparing process for medical preparation and use thereof

A polysaccharide and extraction method technology of Polygonatum japonica is applied in the directions of drug combinations, medical preparations containing active ingredients, pharmaceutical formulations, etc. Active ingredient groups, etc.

Inactive Publication Date: 2004-12-29
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above polysaccharide preparation method has the following disadvantages: 1. It has darker yellow and brown colors, and it is difficult to decolorize; 2. The extraction process is complicated and takes a long time, high cost, and large-scale production is difficult; 3. Organic solvents are used in the extraction and refining process 4. Most of them contain monosaccharides
In short, the above methods are not easy to obtain high-purity polysaccharides
[0006] At the same time, there are also the following deficiencies in the research on Polygonatum Polygonatum: 1. There are more researches on the compound prescription of Polygonatum Polygonatum, but less research on single Polygonatum ...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0073] Dried Polygonatum 9Kg and cut into small pieces, add 10 times the amount of water, boil and extract for 1 hour, filter the extract, add 10 times more water to the dregs, boil and extract for 1 hour, filter the extract, and combine the two extracts , centrifuged, the supernatant was concentrated under reduced pressure to a relative density of 1.15 (50°C), placed at room temperature, added 95% ethanol to make the alcohol content 80%, stirred and left for 12 hours, separated to get the precipitate , wash with cold distilled water 1.5 times, heat the distilled water to dissolve the precipitate, add 95% ethanol to make the alcohol content 70%, let it stand for 12 hours, separate the precipitate, wash three times with 3 times the amount of 95% ethanol, discard The alcohol washing solution and the precipitate were freeze-dried for 12 hours, then vacuum-dried to dryness at a temperature of 60° C., taken out, and pulverized to obtain 340 g of white powder with a yield of 3.8% and...

specific Embodiment 2

[0074] Dried Polygonatum 10Kg and cut into small pieces, add 10 times the amount of water, boil and extract for 1 hour, filter the extract, add 10 times more water to the dregs, boil and extract for 1 hour, filter the extract, and combine the two extracts , centrifuged, the supernatant was concentrated under reduced pressure to a relative density of 1.15 (50° C.), placed at room temperature, added 95% ethanol to make the alcohol content 80%, left to stand for 12 hours, separated to get the precipitate, Add cold distilled water to wash 1.5 times, dissolve the alcohol precipitate in water, make a 1:10 (alcohol precipitate: water) suspension, and centrifuge to remove the insoluble matter. First use a hollow fiber ultrafiltration column with a relative molecular weight cut-off of 40,000 to remove macromolecular substances such as gums with a relative molecular weight greater than 40,000, the flow rate is 20ml / min, and the pressure is 0.15×106Pa; then use a hollow fiber ultrafiltrat...

specific Embodiment 3

[0075] Capsule preparation: Polygonatum polysaccharide 50g

[0076] Micronized silica gel 50g

[0077] Dextrin 50g

[0078] About 1000 capsules can be made

[0079] Mix the prescription amount of micro-powder silica gel and dextrin, then add it to the prescription amount of polysaccharide, mix well, vacuum dry (vacuum degree 0.08-0.09Mpa), crush, mix well, pack into capsules (No. 2), about 1000 grain. Each capsule weighs 0.15g, and each capsule contains 0.05g Polygonatum polysaccharide.

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PUM

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Abstract

The present invention relates to extraction process of fragrant solomonseal polysaccharide and its medicine preparation and use. Fragrant solomonseal polysaccharide extracting process includes cutting fragrant solomonseal rhizome into small dices, twice boiling in water, filtering, centrifuging to obtain supernatant, decompression concentration to relative density of 1.08-1.25, ethanol precipitation, dissolving the precipitate in hot distilled water, ethanol precipitation to obtain precipitate, thrice alcohol washing of the precipitate, freeze drying, vacuum drying and crushing to obtain white powdered fragrant solomonseal polysaccharide. The fragrant solomonseal polysaccharide may be further prepared into various fragrant solomonseal polysaccharide preparations, including tablet, capsule, granule, oral liquid, etc. via adding proper amount of supplementary material and the preparations has the functions of lower blood sugar and blood fat.

Description

technical field [0001] The invention relates to a method for extracting polysaccharides from polygonatum polysaccharides, a method for preparing pharmaceutical preparations and uses thereof. Background technique [0002] Cardiovascular disease has become one of the most important diseases affecting the health of our people. Hyperlipidemia is not only a common cardiovascular disease, but also an important pathogenic factor of atherosclerosis (AS) and coronary heart disease. Blood lipid-lowering drugs It can delay and partially reverse the progression of atherosclerotic lesions, prevent plaque rupture, improve endothelial function, and significantly reduce the morbidity and mortality of cardiovascular diseases. At present, blood lipid-regulating drugs can be divided into the following categories according to their functions: ① Drugs mainly lowering blood cholesterol: including bile acid complexing agents, hydroxymethylglutaryl coenzyme (HMG-CoA) reductase inhibitors, steroid d...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P3/06A61P3/10C08B37/00
Inventor 向大雄刘韶李焕德李新中朱运贵张毕奎龚莉
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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