Process for extracting polygonatum polysaccharides, preparing process for medical preparation and use thereof

Abstract

The present invention relates to extraction process of fragrant solomonseal polysaccharide and its medicine preparation and use. Fragrant solomonseal polysaccharide extracting process includes cutting fragrant solomonseal rhizome into small dices, twice boiling in water, filtering, centrifuging to obtain supernatant, decompression concentration to relative density of 1.08-1.25, ethanol precipitation, dissolving the precipitate in hot distilled water, ethanol precipitation to obtain precipitate, thrice alcohol washing of the precipitate, freeze drying, vacuum drying and crushing to obtain white powdered fragrant solomonseal polysaccharide. The fragrant solomonseal polysaccharide may be further prepared into various fragrant solomonseal polysaccharide preparations, including tablet, capsule, granule, oral liquid, etc. via adding proper amount of supplementary material and the preparations has the functions of lower blood sugar and blood fat.

Description

technical field [0001] The invention relates to a method for extracting polysaccharides from polygonatum polysaccharides, a method for preparing pharmaceutical preparations and uses thereof. Background technique [0002] Cardiovascular disease has become one of the most important diseases affecting the health of our people. Hyperlipidemia is not only a common cardiovascular disease, but also an important pathogenic factor of atherosclerosis (AS) and coronary heart disease. Blood lipid-lowering drugs It can delay and partially reverse the progression of atherosclerotic lesions, prevent plaque rupture, improve endothelial function, and significantly reduce the morbidity and mortality of cardiovascular diseases. At present, blood lipid-regulating drugs can be divided into the following categories according to their functions: ① Drugs mainly lowering blood cholesterol: including bile acid complexing agents, hydroxymethylglutaryl coenzyme (HMG-CoA) reductase inhibitors, steroid d...

AI Technical Summary

Problems solved by technology

The above polysaccharide preparation method has the following disadvantages: 1. It has darker yellow and brown colors, and it is difficult to decolorize; 2. The extraction process is complicated and takes a long time, high cost, and large-scale production is difficult; 3. Organic solvents are used in the extraction and refining process 4. Most of them contain monosaccharides

In short, the above methods are not easy to obtain high-purity polysaccharides

[0006] At the same time, there are also the following deficiencies in the research on Polygonatum Polygonatum: 1. There are more researches on the compound prescription of Polygonatum Polygonatum, but less research on single Polygonatum Polygonatum; Active ingredient or active ingredient group of Polygonatum odoratum pharmacological action

3. There is no report on the extraction and preparation of Polygonatum polysaccharides; 4. In traditional Chinese medicine, Polygonatum is mainly used to nourish yin and nourish the kidney. Reports on the reduction of blood pressure, and reports on the inhibitory effect of the extract on hyperglycemia caused by adrenaline, glucose, and alloxan (see Ma Qingjun, Wang Shuling, editor-in-chief. Clinical Practical Chinese Materia Medica, Jiangxi Science and Technology Press, 2002

), but there is no literature report on Polygonatum polysaccharides lowering blood sugar, especially blood lipids;