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Cefepime compound antibacterial drugs

A cefepime and drug technology, applied in the field of fourth-generation cephalosporin antibiotics, can solve the problems of insensitivity to β-lactamase-producing bacteria and poor efficacy

Inactive Publication Date: 2005-01-19
张哲峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a drug with a wider antibacterial spectrum and stronger antibacterial effect for the defects that the existing single cefepime component drug is insensitive to cefepime-resistant bacteria, β-lactamase-producing bacteria, and has poor curative effect. cefepime antimicrobial combination

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Under sterile and clean conditions, 10 kg of cefepime inner salt and 5 kg of potassium clavulanate (calculated as free acid) were mixed, and operated according to the powder injection preparation process procedure to prepare 10,000 powder injections of the present invention.

Embodiment 2

[0023] Embodiment 2: Under aseptic and clean conditions, 10 kilograms of cefepime hydrochloride (calculated by cefepime) and 20 kilograms of potassium clavulanate (calculated as free acid) were mixed, and the powder injection preparation process was operated to prepare this product. 10,000 powder injections were invented.

Embodiment 3

[0024] Embodiment 3: Under aseptic and clean conditions, 10 kilograms of cefepime (calculated as cefepime), 1 kilogram of potassium clavulanate (calculated as free acid) and 7.25 kilograms of L-arginine are mixed, press freeze-dried The powder injection preparation process is operated to prepare 10,000 powder injections of the present invention.

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PUM

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Abstract

The invention discloses a cefepime antibacterial drug comprising cefepime and beta-lactam enzyme inhibitor by the ratio by weight of 1:2 to 1:0.1, wherein the cefepime is cefepime inner salt, or cefepime hydrochlorate, or cefepime hydrochlorate hydrate, or one of the former medicaments with added adjunct (L-arginine, or sodium carbonate, or sodium hydrogen carbonate, the beta-lactam enzyme inhibitor can be Tazobactam, or clavulanic acid, or tapazole or their derivatives.

Description

technical field [0001] The invention relates to fourth-generation cephalosporin antibiotics, namely a cefepime (Cefepime) antibacterial combination drug. Background technique [0002] The antibacterial activity of the fourth-generation cephalosporin antibiotic Cefepime (Cefepime) is similar to that of the third-generation cephalosporin antibiotic, but the antibacterial spectrum has been further expanded, and it is effective against G+ bacteria including Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, saprophytic bacteria Staphylococcus, Streptococcus pneumoniae (including penicillin-resistant strains with penicillin MIC of 0.1-1.0 μg / ml) and other hemolytic streptococci have obvious antibacterial effects; G-bacteria include Pseudomonas, Escherichia coli, Klebsiella, Enterobacter, Proteus, Acinetobacter calcoacetate, Aeromonas hydrophila, Capnocytophaga, Citrobacter, Campylobacter jejuni, Gardnerella vaginalis, Haemophilus, Nai...

Claims

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Application Information

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IPC IPC(8): A61K31/545A61P31/04
Inventor 张哲峰
Owner 张哲峰
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