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Method for preparing noumenal modification polymethyl methacrylate micro flow control chip

A technology of polymethyl methacrylate and methyl methacrylate is applied in measurement devices, material analysis by electromagnetic means, instruments, etc., and can solve the problems of poor reproducibility of the same chip, deformation of capillary grooves, etc. To achieve the effect of simple operation, improved separation and good reproducibility

Inactive Publication Date: 2005-06-29
FUDAN UNIV
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AI Technical Summary

Problems solved by technology

The production of polymer chips mainly uses techniques such as injection molding, stamping and casting, but the capillary grooves on the produced plastic chips are deformed, which is somewhat different from the design value, and the reproducibility of the same chip is not good.

Method used

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  • Method for preparing noumenal modification polymethyl methacrylate micro flow control chip
  • Method for preparing noumenal modification polymethyl methacrylate micro flow control chip
  • Method for preparing noumenal modification polymethyl methacrylate micro flow control chip

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Embodiment Construction

[0022] Further describe the present invention below by embodiment and accompanying drawing:

[0023] 1. Fabrication of polymethyl methacrylate microfluidic chip modified with methacrylic acid body

[0024] (A) The design of the electrophoresis chip uses Adobe Illustrator 10.0 software to design the capillary channel and solution connection hole of the chip, and uses a high-resolution (3600dpi) laser phototypesetting system to print a mask negative on a polyester transparent film. The channel width is 50 μm, and the solution connection hole is a circular hole with a diameter of 2 mm, in which the microfluidic channel (separation capillary 2 and injection capillary 7) and solution holes 1, 4, 5 and 6 ( figure 1 ) is transparent and the rest is black. The positive image of the microfluidic chip see figure 1 . The separation microfluidic channel 2 is 6.0 cm long, and the sampling microfluidic channel 5 is 0.5 cm long, and the distance from the intersection of capillary tubes 4 ...

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Abstract

This invention belongs to biological test technique field, which is in detail is the process method of the polymethyl methacryate microflow control core with body modification. The method is the following: first to mix the methyl methacrylate with the modification agent; to join thermal initiation agent and light initiation agent into the mixture liquid; to pre-focus the single liquid by heating in the water; to inject the pre-focus liquid into the chip model; to get the micro-flow control chip base by ultraviolet light shining and body initiation; then to cover and seal the micro-flow control chip.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and in particular relates to a method for preparing a body-modified polymethyl methacrylate microfluidic chip. Background technique [0002] Since A. Manz et al. [1] first proposed the micro total analysis system (μ-TAS) in 1990, as a new interdisciplinary field, its goal is to realize chemical analysis system from The overall miniaturization, integration and portability from sample processing to detection is an important direction and frontier in the development of analytical instruments. The microfluidic chip is characterized by the structure of the micropipeline network, which is the focus of the development of the current micro-total analysis system, and has attracted domestic and foreign analysis and life sciences due to its advantages of high efficiency, rapidity, less reagent consumption, low consumption and high integration. It has shown good application prospects in the fie...

Claims

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Application Information

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IPC IPC(8): G01N27/00G01N35/00
Inventor 陈刚张鲁雁杨芃原吴性良
Owner FUDAN UNIV
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