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Levofloxacin dripping pills and its preparing process

A technology of levofloxacin lactate and levofloxacin hydrochloride, which is applied in the directions of pill delivery, medical preparations containing active ingredients, antibacterial drugs, etc., can solve problems such as insufficient efficacy, and achieve increased bioavailability, reduced side effects, and drug efficacy. quick effect

Inactive Publication Date: 2005-07-06
彭红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no one that uses levofloxacin lactate or levofloxacin hydrochloride to make oral drops, and its effectiveness has not been fully exerted.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Prescription: Levofloxacin Lactate 10.0g

[0016] Macrogol 4000 5.0g

[0017] Glyceryl monostearate 2.0g

[0018] Poloxamer 0.5g

[0019] Polyethylene glycol 6000 10.0g

[0020] Made into 1000 capsules, with an average of 27.5mg per capsule

[0021] Add 10.0g of levofloxacin lactate to 10.0g of polyethylene glycol 6000, 2.0g of glyceryl monostearate, 5.0g of polyethylene glycol 4000, and 0.5g of poloxamer, heat, melt and mix well, and then heat and mix them at 70°C-95°C In the state, drip into the condensation of simethicone oil at a rate of 40 drops per minute. After forming, take it out, remove the condensing agent, check the amount of ingredients, pass it, pack it, and get the finished product. Every 1000 levofloxacin lactate dripping pills contains 10.0g of levofloxacin lactate.

[0022] The test method is: this product is a white or slightly yellow dripping pill with a bitter taste. The content determination method is a high performan...

Embodiment 2

[0024] Prescription: Levofloxacin Hydrochloride 5.0g

[0025] Macrogol 4000 15.0g

[0026] Polyethylene glycol 6000 5.0g

[0027] Made into 1000 capsules, with an average of 25.0mg per capsule

[0028] Add 5.0g of levofloxacin hydrochloride to 5.0g of polyethylene glycol 6000, 15.0g of polyethylene glycol 4000, heat, melt and mix well, then drop it into the liquid paraffin condensed oil at a rate of 50 drops per minute at 80°C-95°C , after forming, take it out, remove the condensing agent, inspect the component quantity, pass it, pack it, and get the finished product. Every 1000 levofloxacin hydrochloride dripping pills contains 5.0g of levofloxacin hydrochloride.

[0029] The inspection method is: this product is in the form of slightly yellow dripping pills with a bitter taste. The content determination method is a high performance phase chromatography using octadecylsilane bonded silica gel as a filler.

Embodiment 3

[0031] Prescription: Levofloxacin Lactate 2.0g

[0032] Glycerin Gelatin 5.0g

[0033] Polyoxyethylene monostearate 10.0g

[0034] Macrogol 4000 13.0g

[0035] Made into 1000 capsules, with an average of 30.0mg per capsule

[0036] Add 2.0g of levofloxacin lactate to 13.0g of polyethylene glycol 4000, 5.0g of glycerin gelatin, and 10.0g of polyoxyethylene monostearate; Drop it into the condensed vegetable oil at a high speed, after forming, take it out, remove the condensing agent, check the amount of ingredients, pass it, pack it, and get the finished product. Every 1000 levofloxacin lactate dripping pills contains 2.0g of levofloxacin lactate.

[0037] The inspection method is: this product is in the form of slightly yellow dripping pills with a bitter taste. The content determination method is a high performance phase chromatography using octadecylsilane bonded silica gel as a filler.

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PUM

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Abstract

The invention discloses a lactic acid levofloxacin dripping pills and its preparing process, wherein each drop pill contains Levofloxacin 1-10 mg and right amount of drop pill base material, the drop pill base material is selected from one or two of polyethylene glycol 6000, polyethylene glycol 4000, polyoxyethglene monostearate, sodium stearate, glycerol gelatine, poloxamer, stearic acid, glyceryl monostearate, insect wax. And the preparing process comprises the steps of heating till melting, mixing homogeneously, instilling into condensation agent, taking-up and removing the condensation agent, checking and packaging.

Description

technical field [0001] The invention relates to an oral drop pill, in particular to a levofloxacin lactate drop pill or levofloxacin hydrochloride drop pill with broad-spectrum antibacterial effect and a preparation method. Background technique [0002] Lactic acid or levofloxacin hydrochloride, chemical name (-) 9-fluoro-3-methyl-10-[4-methyl-piperazinyl]-7-oxo-2,3-dihydro-7H-pyrido[1 , 2,3-de]-[1,4]benzoxazine-6-carboxylic acid lactic acid or hydrochloride. It is the L-isomer of ofloxacin S configuration, white or yellowish crystalline powder, odorless, bitter taste, gradually changing color when exposed to light. It is a third-generation quinolone broad-spectrum antibacterial synthetic drug. For Staphylococcus, Streptococcus, Streptococcus pneumoniae, Neisseria gonorrhoeae, Escherichia coli, Citrobacter, Shigella, Klebsiella pneumoniae, Enterobacter, Haemophilus influenzae, Acinetobacter, Helicobacter, etc. Good antibacterial effect. It has certain antibacterial activ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/5383A61P31/04
Inventor 彭红许军
Owner 彭红
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