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Wilsonii oral disintegrating tablet and preparation method thereof

A technology of Acanthopanax and Acanthopanax extract, which is applied in the direction of medical preparations containing active ingredients, pill delivery, digestive system, etc., and can solve problems such as high manufacturing and medical costs, difficulty in taking it by patients, and difficult operation

Inactive Publication Date: 2005-07-06
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Due to the dosage form, most oral preparations need to be taken with a lot of water, which makes it difficult for many elderly people, infants, or patients with difficulty swallowing and inconvenient water intake.
Injections are often prone to allergic reactions or adverse reactions, etc. At the same time, injections also have the disadvantages of difficult operation, great pain for patients, high manufacturing and medical costs, and heavy economic burden for patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Direct Preparation Method of Acanthopanax Radix Extract

[0040] 1. Prescription:

[0041] Acanthopanax extract 150g

[0042] Microcrystalline Cellulose 150g

[0043] Mannitol 130g

[0044] Low-substituted hydroxypropyl cellulose 20g

[0045] Crospovidone 20g

[0046] Low-substituted hydroxypropyl cellulose 20g

[0047] Magnesium Stearate 5g

[0048] Proper amount of ethanol

[0049] Sodium carboxymethyl starch appropriate amount

[0050] Pressed into 1000 pieces

[0051] Second, the preparation process:

[0052] Take 150g of Acanthopanax acanthopanax extract, add 30ml-50ml of water to make a dilute extract with good fluidity, use stirring granulation method, add the dilute extract to 150g microcrystalline cellulose, stir and granulate. The wet granules are taken out, dried at 50°C for 2 hours, taken out, granulated, and set aside.

[0053] 130 grams of mannitol, 20 g of low-substituted hydroxypropyl cellulose, granulate...

Embodiment 2

[0057] Embodiment 2: Acanthopanax fine powder direct preparation method

[0058] 1. Prescription:

[0059] Acanthopanax fine powder 150g

[0060] Microcrystalline Cellulose 150g

[0061] Mannitol 130g

[0062] Low-substituted hydroxypropyl cellulose 20g

[0063] Crospovidone 20g

[0064] Low-substituted hydroxypropyl cellulose 20g

[0065] Magnesium Stearate 5g

[0066] Proper amount of ethanol

[0067] Sodium carboxymethyl starch appropriate amount

[0068] Pressed into 1000 pieces

[0069] Second, the preparation process:

[0070] Get 150 g of Acanthopanax senticosus fine powder and 150 g of microcrystalline cellulose, mix well, and use 85% ethanol as a wetting agent to stir and granulate. The wet granules are taken out, dried at 50°C for 2 hours, taken out, sorted, and set aside.

[0071] 130 grams of mannitol, 20 g of low-substituted hydroxypropyl cellulose, granulated with 2% sodium carboxymethyl starch slurry, dried at 50° C. for 2 hours...

Embodiment 3

[0074] Example 3 : Acanthopanax fine powder fluidized bed granulation method

[0075] prescription:

[0076] Acanthopanax fine powder 150g

[0077] Microcrystalline Cellulose 120g

[0078] Micronized silica gel 2g

[0079] Mannitol 150g

[0080] Low-substituted hydroxypropyl cellulose 20g

[0081] Crospovidone 20g

[0082] Low-substituted hydroxypropyl cellulose 25g

[0083] Magnesium Stearate 5g

[0084] Proper amount of ethanol

[0085] Sodium carboxymethyl starch appropriate amount

[0086] Pressed into 1000 pieces

[0087] Preparation Process:

[0088] Get Acanthopanax fine powder 150g, microcrystalline cellulose 120g, micropowder silica gel 2g, mix evenly, put in the fluidized bed, use 80%-90% ethanol as binder, spray into the fluidized bed for powder direct Granulation. The granules were dried at 40°C for later use.

[0089] 150 grams of mannitol, 20 g of low-substituted hydroxypropyl cellulose, granulated with 2% sodium carboxymethyl...

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PUM

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Abstract

The invention relates to a wilsonii oral disintegrating tablet and its preparation process, wherein the tablet has the functions of enlivening the spleen, tonifying kidney and tranquillizing the mind, the preparation employs wilsonii extract as the raw material, and bulking agent, crumbling agent, flavoring agent, flow aid, and lubricating agent as adjuvant, bonding agent or dressing material can also be employed based on specific situation.

Description

technical field [0001] The invention relates to an Acanthopanax orally disintegrating tablet preparation which has the functions of nourishing qi and invigorating the spleen, nourishing the kidney and calming the nerves, and is used for symptoms such as spleen and kidney yang deficiency, physical weakness, loss of appetite, sore waist and knees, insomnia and dreaminess. Background technique [0002] "Compendium of Materia Medica" records that "Acanthopanax can replenish strength and improve essence, improve eyesight and lower qi", "can nourish five labors and seven injuries, and take it for a long time to lighten the body and endure old age". Modern medical and clinical studies have shown that eleuthero extracts have the following physiological functions: [0003] ①Dilate blood vessels, lower blood pressure, resist platelet aggregation, improve blood rheological properties and improve microcirculation; [0004] ② Improve the hemorheological properties of hyperlipidemia and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P1/14A61P25/20
Inventor 蒋海松王锦刚
Owner COSCI MED TECH CO LTD
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