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Refining method for Liuweidihuang compound preparation by membrane technology separation

A technology of Liuwei Dihuang and compound preparations, which can be applied to medical formulas, medical preparations containing active ingredients, and the digestive system. It can solve problems such as high production costs, large dosages, and inability to satisfy patients, and achieve the effect of reducing production costs.

Active Publication Date: 2005-10-19
JIANGZHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the chemical components in the prescription are soluble in water. The water-soluble ingredients in the prescription can be extracted by decoction, but the amount of the extract is large. If it is not purified, it will inevitably lead to a large dosage, which cannot meet the needs of patients. needs
[0004] At present, Liuwei Dihuang preparations have various dosage forms such as mixture, oral liquid, granules, tablets, honeyed pills, watered pills, concentrated pills, creams, soft capsules, hard capsules, etc. Most of the extraction processes use water extraction, water extraction, alcohol precipitation or Prepared by techniques such as alcohol reflux extraction, the process is more complicated, consumes a large amount of organic solvents, and the extract contains a large amount of impurities, which has the disadvantages of being difficult to take or taking a large dose (8 capsules each time); the existing publication number 1449806 patent document "Production Process of Chinese Medicine Liuwei Dihuang Preparation" discloses the use of multiple ultrafiltration technology to extract polysaccharides in Liuwei Dihuang recipe, and use macroporous resin to absorb small molecule active ingredients in the recipe, the process is quite complicated; Non-patent literature such as Wang Houting disclosed the method of extracting polysaccharides with ultrafiltration technology in the "Technology Research on Ultrafiltration Extraction of Liuwei Dihuang Tang Active Polysaccharides" published in the second phase of "Journal of Liberation Army Pharmacy" in 2001, but other methods in the prescription The small molecule active ingredient failed to separate; another example is the article "Macroporous resin adsorption and ultrafiltration combined with paeonol and loganin in Liuwei Dihuang Pills" published in the second issue of "Journal of Nanjing University of Traditional Chinese Medicine" in 1999 by Guo Liwei and others. Influence of content", the extraction process first uses macroporous resin technology to extract small molecule active ingredients in water decoction, and then uses ultrafiltration technology to extract polysaccharides. Although it can effectively reduce the dosage, the process is relatively complex and relatively high production cost; therefore, it is particularly urgent to find a method that can effectively extract the active ingredients in Liuwei Dihuang compound preparation, further separate and refine, remove invalid impurities, and have a simple process and low cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] prescription:

[0053] Rehmannia glutinosa 320g, dogwood 160g, peony bark 120g

[0054]Poria cocos 120g Yam 160g Alisma 120g

[0055] Take a total of 1 kg of the above six herbs, add water to soak for 40 minutes, decoct and extract twice, add 9 times the amount of medicinal materials for the first time, decoct for 1 hour, and add water for 7 times the amount of medicinal materials for the second time; decoct After 0.5 hour, combine the water decoction, centrifuge at a high speed (20,000 rpm), and set the volume of the filtrate to 14 liters, take a 0.04 square meter flat ultrafiltration membrane made of polysulfone with a molecular weight cut-off of 6000 and press "full filtration" Operation method Perform ultrafiltration (feed liquid temperature 20-45°C, inlet pressure 4-6bar, outlet pressure 0.5-1.5bar), collect 16 liters of ultrafiltrate, concentrate the ultrafiltrate under reduced pressure, and dry under reduced pressure to obtain the extract 92 grams, mixed with a...

Embodiment 2

[0057] prescription:

[0058] Rehmannia glutinosa 320g, dogwood 160g, peony bark 120g

[0059] Poria cocos 120g Yam 160g Alisma 120g

[0060] Take a total of 1 kg of the above six herbs, add water to soak for 40 minutes, decoct and extract twice, add 9 times the amount of medicinal materials for the first time, decoct for 1 hour, and add water for 7 times the amount of medicinal materials for the second time; decoct After 0.5 hour, the water decoction was combined, and through high-speed centrifugation (20,000 rpm), the filtrate was fixed to 14 liters, and the material with a molecular weight cut-off of 6000 was 0.04 square meters of flat-plate ultrafiltration membrane of cellulose acetate and pressed "full filtration "Operation method: carry out ultrafiltration (feed liquid temperature 20-45 °C, inlet pressure 4-6 bar, outlet pressure 0.5-1.5 bar), collect 16 liters of ultrafiltrate, concentrate the ultrafiltrate under reduced pressure, and dry it under reduced pressure to o...

Embodiment 3

[0062] Rehmannia glutinosa 160g Cornus officinalis 80g Moutan bark 60g

[0063] Poria cocos 60g Chinese yam 80g Alisma 60g

[0064] Take a total of 0.5 kg of the above six herbs, soak in water for 40 minutes, decoct and extract twice, add 9 times the amount of medicinal materials for the first time, decoct for 1 hour, and add water for 7 times the amount of medicinal materials for the second time; decoct After 0.5 hour, combine the water decoction, centrifuge at a high speed (20,000 rpm), set the filtrate to 6 liters, take a 0.04 square meter flat ultrafiltration membrane made of polysulfone with a molecular weight cut-off of 5000, and press "full filtration" Operation method Perform ultrafiltration (feed liquid temperature 20-45°C, inlet pressure 4-6bar, outlet pressure 0.5-1.5bar), collect 8 liters of ultrafiltrate, concentrate the ultrafiltrate under reduced pressure, and dry under reduced pressure to obtain the extract 46 grams, add appropriate amount of auxiliary materia...

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PUM

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Abstract

The present invention relates to the membrane separating and fining process of compound Chinese medicine Liuweidihuang preparation comprising Chinese medicinal materials prepared rhizome of rehmannia, dogwood, tree peony bark, Chinese yam, tuckahoe and oriental water plantain. The conventional water extract is ultrafiltered with organic membrane of polysulfone or acetate cellulose with intercepting molecular weight 5000-40000, so as to extract the effective components, with the effective components being further concentrated and dried. The said process is simple, has no organic solvent consumption, ensured product quality, low dosage and low cost, and is suitable for automatic production.

Description

technical field [0001] The invention relates to a membrane technology separation and refining method for a compound preparation of Liuwei Dihuang, which is a method for extracting and refining active components by using a membrane separation process to remove impurities and reduce dosage for the water decoction of the compound preparation of Liuwei Dihuang. Background technique [0002] Liuwei Dihuang Decoction was first created by Song Qianyi in "Pediatric Medicine and Syndrome Straight Formula". It is a classic prescription for nourishing yin and tonifying kidney. Night sweats, soreness of the waist and knees, insomnia, dreaminess, red tongue with little moss, thready and rapid pulse, etc. can be used for liver and kidney yin deficiency, and it is suitable for all yin deficiency and hyperactivity of fire. [0003] The formula of Liuwei Dihuang compound preparation comes from Liuwei Dihuang Decoction. The chemical components of Rehmannia glutinos...

Claims

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Application Information

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IPC IPC(8): A61P1/14A61P25/20
Inventor 季巧遇于长华
Owner JIANGZHONG PHARMA