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Process for preparing high purity breviscapine B raw material medicine

A technology for preparing scutellarin and its preparation technology, which is applied in the field of raw material medicine preparation technology, can solve the problems of improving the purity of scutellarin and eliminating side effects that have not been reported, and achieves easy industrial production, reduced toxicity, and simple process steps Effect

Active Publication Date: 2006-01-04
KUNMING LONGJIN PHARMA
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Problems solved by technology

There is no report on the refining process of scutellarin in the relevant literature and patent materials, and there is no report on the improvement of the purity of scutellarin and the elimination of side effects

Method used

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  • Process for preparing high purity breviscapine B raw material medicine

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Embodiment

[0021] Weigh 1000g of commercially available breviscapine crude drug, add 5 times the volume of water, adjust the pH value to 7 with 20% disodium hydrogen phosphate test solution, make it completely dissolved, filter, add 8 times of acetone to the filtrate to precipitate, stir while adding, Make the precipitation complete, let stand for 10 hours, filter, add acetone to wash three times, then move the precipitate to another container, add 5 times the amount of 30% acetone, stir well, add 20% hydrochloric acid to adjust the pH to 1-2 Set it aside for 10 hours, filter with suction, wash with water until neutral, wash once with ethanol, and dry to obtain refined scutellarin. The content of scutellarin by HPLC analysis is 99.43%, as shown in the attached figure.

[0022] Detection method: chromatographic conditions and system suitability test (using octadecyl bonded silica gel as filler: methanol-0.1% phosphoric acid solution (40:60) as mobile phase; detection wavelength is 335nm. T...

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PUM

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Abstract

The present invention relates to pharmaceutical technology, and is especially high purity material medicine preparation process. The preparation process of high purity breviscapine B material medicine consists of the following steps: 1. setting breviscapine in some container, adding 2 times or more water, adding alkali metal phosphate to regulate pH to 4-8 for dissolving completely; 2. adding 3 times or more solvent for depositing, letting stand, filtering and washing the precipitate with solvent; and 3. shifting the precipitate to solution with 10-60 wt% of solvent, adding acid to acidify to pH 2, filtering precipitate, water washing to neutrality, and drying to obtain high purity breviscapine B material medicine.

Description

technical field [0001] The invention relates to a preparation process of a bulk drug in the pharmaceutical industry, in particular to a preparation process of a high-purity bulk drug. Background technique [0002] Erigeron breviscapus (Vant.) Hand-Mazz is a flavonoid active ingredient isolated from the whole herb of Erigeron breviscapus (Vant.) Hand-Mazz, mainly scutellarin (also known as breviscapus, scutellarin, hereinafter referred to as B) , the chemical name is 4′5,6-trihydroxyflavone-7-O-glucuronide. The breviscapine raw material drug purchased from the market is analyzed by HPLC, and the content of B is about 90%. This preparation has been widely used clinically to treat cardiovascular and cerebrovascular diseases, and its curative effect is remarkable. However, its injection has poor stability and short storage time. Clinically, individual patients may experience cold and heat reactions, skin itching, and rashes after use. The appearance of the phenomenon is mainly ...

Claims

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Application Information

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IPC IPC(8): C07H17/07A61K31/7048
Inventor 张人伟程惠佳樊献俄
Owner KUNMING LONGJIN PHARMA
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