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Method for preparing 'Fen Ma Mei Yu' dispersible tablet

A technology for dispersible tablets and pseudoephedrine hydrochloride, which is applied in the field of preparation of Phenomameiyu dispersible tablets, can solve the problems of low melting point, high processing cost, easy volatility and the like, and achieves safe and effective clinical application, stable effective components of medicine, and bioavailability. high effect

Active Publication Date: 2006-05-10
四川泰华堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] When preparing fenmameiyu dispersible tablets, there are following difficulties: after the guaiacol glyceryl ether is mixed with the rest of the components, the mixture is not easy to dry, delaying the process, and the processing cost is high
At the same time, due to the low melting point of guaiacol glyceryl ether, it is easy to volatilize, and the proportion of active ingredients is difficult to accurately control, so the quality of the product is difficult to guarantee

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Get the following components by weight (unit g) ratio

[0038] Main ingredients: Acetaminophen 250; Pseudoephedrine hydrochloride 30;

[0039] Dextromethorphan Hydrobromide 15; Guaifenesin 100.

[0040] Excipients: microcrystalline cellulose 95; stevia 5;

[0041] Low-substituted hydroxypropyl cellulose 160; Sodium carboxymethyl starch 30;

[0042] Magnesium Stearate 3; 50% Ethanol 180.

[0043] Prepare 1000 tablets according to the following specific steps

[0044] 1. Grind the above main and auxiliary materials to 100 mesh respectively.

[0045] 2. Preparation of guaiacol glyceryl ether granules: (1) Take 80 g of low-substituted hydroxypropyl cellulose and 100 g of guaiacol glycerin ether in an airtight mixer and mix them uniformly by equal addition method; (2) add 50% 60 g of ethanol was used to granulate the mixed material with a sieve to make 40-mesh granules; (3) the granules were dried at a temperature of 50° C. for 2 hours.

[0046] 3. Pr...

Embodiment 2

[0049] Get the following components by weight (unit g) ratio

[0050] Main ingredients: Acetaminophen 250; Pseudoephedrine hydrochloride 30;

[0051] Dextromethorphan Hydrobromide 15; Guaifenesin 100.

[0052] Excipients: microcrystalline cellulose 120; aspartame 5;

[0053] Sucrose 25; Hydroxypropyl methylcellulose 150;

[0054] Starch 30; Mint essence 10;

[0055] stearic acid 5; water 100.

[0056] Prepare 1000 tablets according to the following specific steps

[0057] 1. Grind the above main and auxiliary materials to 120 mesh respectively.

[0058]2. Preparation of guaiacol glyceryl ether granules: (1) Take 80 g of hydroxypropyl methylcellulose, 20 g of microcrystalline cellulose, and 100 g of guaiacol glycerin ether and mix them uniformly in an airtight mixer with equal volume addition; (2) Add 30 g of water to granulate the mixed material with a screen to make 30-mesh granules; (3) Dry the granules at 45° C. for 5 hours.

[0059] 3. Prepar...

Embodiment 3

[0062] Get the following components by weight (unit g) ratio

[0063] Main ingredients: Acetaminophen 250; Pseudoephedrine hydrochloride 30;

[0064] Dextromethorphan Hydrobromide 15; Guaifenesin 100;

[0065] Excipients: microcrystalline cellulose 100; mannitol 30;

[0066] Low-substituted hydroxypropyl cellulose 130; sweet orange essence 8;

[0067] Sodium carboxymethyl starch 15; Talc 3;

[0068] 10% Polyvinylpyrrolidone 80.

[0069] Prepare 1000 tablets according to the following specific steps

[0070] 1. Grind the above main and auxiliary materials to 80 mesh respectively.

[0071] 2. Preparation of guaiacol glyceryl ether granules: (1) Take 60 g of low-substituted hydroxypropyl cellulose and 100 g of guaiacol glycerin ether in an airtight mixer and mix them uniformly by equal addition method; (2) add 10% 25 g of polyvinylpyrrolidone and granulating the mixed material with a sieve to make 20-mesh granules; (3) drying the granules at a temper...

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PUM

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Abstract

The invention discloses a process for preparing Paracetamol dispersible tablets, which consists of granulating guaiphenesin carbamate and adjuvant, then granulating acetaminopher, d-pesudoephedrine hydrochloride, Dextromethorphan Hydrobromide and adjuvant, drying the two kinds of particles, finally mixing uniformly and moulding.

Description

technical field [0001] The invention relates to a preparation method of pharmaceutical preparations, in particular to a preparation method of fenmameiyu dispersible tablets. Background technique [0002] Fen Mameiyu Dispersible Tablet is a compound preparation composed of active ingredients such as acetaminophen, dextromethorphan hydrobromide, guaiacol glyceryl ether, pseudoephedrine hydrochloride, disintegrant, adhesive and other auxiliary materials. Pain, anti-nasal congestion, antitussive, expectorant and contraction of upper respiratory tract mucosal blood vessels, mainly used for the treatment of colds and upper respiratory tract infections caused by headache, fever, pain in limbs, nasopharyngeal mucosal hyperemia, nasal congestion, runny nose, cough and Symptoms such as excess phlegm, it is a cold preparation with comprehensive therapeutic effects, and can more effectively improve various symptoms caused by colds compared with the existing cold preparations. The medic...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61K9/20A61K31/137A61K31/167A61P11/02A61P11/10A61P11/14A61P29/00
Inventor 俞凯
Owner 四川泰华堂制药有限公司
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