Externally applied emulsion for treating dermatitis and eczema

A technology for topical cream, dermatitis and eczema, applied in the field of plant materials, can solve the problems of easy occurrence of allergies, narrowed application range, weak anti-inflammatory properties, etc.

Inactive Publication Date: 2006-05-17
西安交大科技园博源生物医药有限责任公司
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical curative effect of the above-mentioned external preparations is not satisfactory due to weak anti-inflammatory properties or poor antipruritic properties or due to the addition of antibacterial and antifungal agents to complicate the prescription, reduce the scope of application, and are prone to allergies

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Externally applied emulsion for treating dermatitis and eczema

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Taking the production of medicament cream of the present invention 1000g as an example, the used medicinal active ingredients and adjuvants and their weight ratios are:

[0032] Clobetasol Propionate 0.5g Borneol 20g

[0033] Stearyl Alcohol 29g Stearic Acid 59g

[0034] Glyceryl monostearate 20g Liquid paraffin 73g

[0035] Glycerin 104g HR-S1 type emulsifier 24g

[0036] Emulsified silicone oil 24g Ethylparaben 1.5g

[0037] Distilled water up to 1000g

[0038] Its preparation method is as follows:

[0039] Take 0.5 g of clobetasol propionate and 20 g of borneol and dissolve in 50 ml of ethanol, seal it and set aside. Weigh 29g of stearyl alcohol, 59g of stearic acid, 20g of glyceryl monostearate, 73g of liquid paraffin, 24g of HR-S1 emulsifier, and 24g of emulsified silicone oil, heat and melt in a water bath to form an oil phase, keep it warm at 80°C, and add distilled water Heat to 90°C, then add 104g of glycerin and 1.5g of ethylparaben to dissolve into water ...

Embodiment 2

[0044] Taking the production of medicament cream of the present invention 1000g as an example, the used medicinal active ingredients and adjuvants and their weight ratios are:

[0045] Clobetasol Propionate 0.66g Borneol 19.84g

[0046] Stearyl Alcohol 29g Stearic Acid 59g

[0047] Glyceryl monostearate 20g Liquid paraffin 73g

[0048] Glycerin 104g HR-S1 type emulsifier 24g

[0049] Emulsified silicone oil 24g Ethylparaben 1.5g

[0050] Distilled water up to 1000g

[0051] Its preparation method is identical with embodiment 1. Each gram contains 0.0205g of medicinal active ingredients.

[0052] In the proportioning of the present embodiment, the parts by weight of each component of the medicinal active ingredient are:

[0053] Clobetasol Propionate 1 part

[0054] 30 servings of borneol

Embodiment 3

[0056] Taking the production of medicament cream of the present invention 1000g as an example, the used medicinal active ingredients and adjuvants and their weight ratios are:

[0057] Clobetasol Propionate 0.40g Borneol 20.1g

[0058] Stearyl Alcohol 29g Stearic Acid 59g

[0059] Glyceryl monostearate 20g Liquid paraffin 73g

[0060] Glycerin 104g HR-S1 type emulsifier 24g

[0061] Emulsified silicone oil 24g Ethylparaben 1.5g

[0062] Distilled water up to 1000g

[0063] Its preparation method is identical with embodiment 1. Each gram contains 0.0205g of medicinal active ingredients.

[0064] In the proportioning of the present embodiment, the parts by weight of each component of the medicinal active ingredient are:

[0065] Clobetasol Propionate 1 part

[0066] borneol 50 servings

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention is externally applied emulsion for treating dermatitis and eczema, and the emulsion is prepared with clobetasol propionate in 1 weight portions and borneol in 30-50 weight portions as the effective components and through conventional preparation process. The material for the emulsion includes also excipient of octadecanol, stearic acid, glycerol monostearate, liquid paraffin, glycerin, HR-S1 emulsifier, emulsifying silica oil and ethyl hydroxybenzoate. Animal experiments show that the emulsion of the present invention has the functions of resisting inflammation, resisting eczema, stopping itch and relieving pain, and may be used in clinical experiment.

Description

technical field [0001] The invention belongs to the technical field of medical preparations containing raw materials or their reaction products with unknown structures, and specifically relates to materials derived from plants. Background technique [0002] Most of the skin diseases are inflammatory skin diseases. Except for a few inflammatory skin diseases, patients all have varying degrees of itching, especially the most common dermatitis and eczema skin diseases, which seriously affect the physical and mental health of patients. Dermatitis and eczema-like skin diseases are common and frequently-occurring diseases in dermatology. Dermatitis includes contact dermatitis, atopic dermatitis, and autosensitivity dermatitis. [0003] Contact dermatitis is the most common skin disorder, accounting for an estimated 4 to 7% of dermatology visits. Contact dermatitis is an acute or chronic inflammatory reaction at the site of skin and mucous membrane contact due to exposure to a sub...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/57A61K9/06A61K31/045A61P17/00
Inventor 李伯勋牛小麟安彩贤刘俊田杨广德
Owner 西安交大科技园博源生物医药有限责任公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap