Film-coated tablet of glycyrrhizinic acid monopotassiium salt and method for preparing the same

A technology of glycyrrhizic acid monopotassium salt and film-coated tablets, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc. Uniformity, sugar-coated tablets take a long time to produce and other problems, to achieve the effect of improving bioavailability, improving appearance and stable properties of the main drug

Inactive Publication Date: 2006-09-06
山东山大康诺制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although sugar-coated tablets are beneficial for patients to take and have a better taste, the sugar-coated tablets in the preparation will increase the weight of the embryo tablets and consume more materials, especially the finished sugar-coated tablets have a large volume, long disintegration and dissolution time, and The drying speed in the production process is slow, and the heating time of the drug is prolonged, which will affect the quality of the drug; in addition, the sugar-coated tablets are prone to mildew, softening, moisture absorption and disintegration; the color of the sugar-coated tablets is uneven, and the labeling is likely to be unclear; moreover , the production of sugar-coated tablets takes a long time and the production cost is relatively high
[0010] In recent years, tablet film coating has become the development direction of pharmaceuticals, and its use in drug production has attracted the attention of the pharmaceutical industry. The application for invention patents related to film coating has gradually increased, but so far, there is no monopotassium glycyrrhizinate film coating tablet. technology disclosure

Method used

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  • Film-coated tablet of glycyrrhizinic acid monopotassiium salt and method for preparing the same
  • Film-coated tablet of glycyrrhizinic acid monopotassiium salt and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Glycyrrhizinic acid monopotassium salt film-coated tablet, with oblate glycyrrhizic acid monopotassium salt tablet with a diameter of 0.8-1.0 cm as the tablet base, the surface of the tablet is spray-coated with a layer of coating material film-coating layer with a thickness of 0.4-0.5 mm.

[0031] The components of the monopotassium glycyrrhizinate tablet are as follows: monopotassium glycyrrhizinate 5g, starch 50g, sucrose 40g, micronized silica gel 5g, magnesium stearate 120g, sodium carboxymethyl starch 130g, sodium lauryl sulfate 50g, 150g of talcum powder, 6g of alcohol 50% by volume. Coating material Opadry 100.0g was added with 900ml of ethanol with a volume percentage of 80% to make slurry.

[0032] The preparation method is as follows:

[0033] Preparation of oblate monopotassium glycyrrhizic acid tablets with a diameter of 0.8 to 1.0 cm: (1) crushing and sieving: the main drug monopotassium glycyrrhizic acid was passed through a 100 mesh sieve, magnesium ste...

Embodiment 2

[0036] Glycyrrhizic acid monopotassium salt film-coated tablet, with oblate glycyrrhizic acid monopotassium salt tablet with a diameter of 0.9-1.1 cm as the tablet base, the surface of the tablet is spray-coated with a layer of coating material film-coating layer with a thickness of 0.5-0.6 mm. (Such as figure 1 shown)

[0037] The components of the monopotassium glycyrrhizinate tablet are as follows: monopotassium glycyrrhizinate 8g, starch 80g, sucrose 70g, micropowder silica gel 8g, magnesium stearate 150g, sodium carboxymethyl starch 170g, sodium lauryl sulfate 80g, 180g of talcum powder, 8g of alcohol 50% by volume. 200.0 g of the coating material Opadry was mixed with 2000 ml of 80% ethanol by volume.

[0038] The preparation method is as follows:

[0039] Preparation of oblate monopotassium glycyrrhizic acid tablets with a diameter of 0.9 to 1.1 cm: (1) crushing and sieving: the main drug monopotassium glycyrrhizic acid was passed through a 100 mesh sieve, magnesium st...

Embodiment 3

[0042] Glycyrrhizic acid monopotassium salt film-coated tablet, with oblate glycyrrhizic acid monopotassium salt tablet with a diameter of 1.0-1.15 cm as the tablet base, the surface of the tablet is spray-coated with a layer of coating material film-coating layer with a thickness of 0.6-0.7 mm.

[0043] The components of the monopotassium glycyrrhizic acid tablet are as follows: monopotassium glycyrrhizinate 10g, starch 100g, sucrose 100g, micronized silica gel 10g, magnesium stearate 200g, sodium carboxymethyl starch 200g, sodium lauryl sulfate 100g, talcum powder 200g, 50% alcohol by volume percentage 10g. Coating material Opadry 300.0g, add 3600ml of ethanol with a volume percentage of 80% to prepare slurry.

[0044] The preparation method is as follows:

[0045] Preparation of oblate monopotassium glycyrrhizic acid tablets with a diameter of 1.0 to 1.15 cm: (1) crushing and sieving: the main drug monopotassium glycyrrhizic acid was passed through a 100 mesh, magnesium st...

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Abstract

This is a glycyrrhizic single-sylvite film coating and its preparing method, which belongs to medicine technique field. Its characteristic is: it takes surbased glycyrrhizic single-sylvite plate, whose diameter is 0.8- 1.2cm as bullet base, and the bullet surface has a 0.3-0.9mm depth dressing material film coating, and the dressing material is damp-proofing. The manufacturing technique of glycyrrhizic single-sylvite film coating contains plate preparation and film coating preparation. This film coating is small, low cost, it has good damp-proofing, strong stability, it increases disintegration and dissolving rate of bullet, heightens biology availability and clinical curative effect. This glycyrrhizic single-sylvite film coating is available for auxiliary therapy in acute and chronic hepatic diseases and liver dysfunction patients, at the same time it relives the use limitation in diabetes patients.

Description

technical field [0001] The invention relates to a film-coated tablet and a preparation method thereof, in particular to a film-coated tablet of monopotassium glycyrrhizinate and a preparation method thereof. Background technique [0002] Glycyrrhizic acid monopotassium salt, the chemical name is: 20β-carboxy-11-oxo-n-oleanane-12-en-3β-yl-2-O-β-D-glucopyranuronic acid-α- D-glucopyranose monopotassium salt. [0003] Structural formula: [0004] [0005] Molecular formula: C 42 h 61 KO 16 [0006] Molecular weight: 861.02 [0007] Properties: The commercially available and clinically applied product is glycyrrhizic acid monopotassium salt sugar-coated tablet, which appears light brown or off-white after removing the sugar coating, and tastes sweet. [0008] Monopotassium glycyrrhizinate tablets are suitable for adjuvant treatment of acute and chronic liver diseases and patients with abnormal liver function, and at the same time lifted the restrictions on the use of di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K9/20A61P1/16A61P31/12
Inventor 赵桂森冯军涛武桂兰刘建峰张泰松李杨
Owner 山东山大康诺制药有限公司
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