Anticancer medicine slow-release preparation containing platinum compound and its synergist
A technology of anticancer drugs and compounds, applied in the direction of active ingredients of heavy metal compounds, non-active ingredients of polymer compounds, antitumor drugs, etc., which can solve problems such as treatment failure and increased tolerance
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Embodiment 1
[0130] Put 80mg polyphenylene propane (p-CPP: sebacic acid (SA) 20:80) copolymer into the container, add 100ml dichloromethane, dissolve and mix well, then add 10mg Cisplatin and 10 mg doxorubicin were shaken again to prepare microspheres for injection containing 10% cisplatin and 10% doxorubicin by spray drying. Then suspend the microspheres in physiological saline containing 15% mannitol to prepare the corresponding suspension-type sustained-release injection. The drug release time of the slow-release injection in physiological saline in vitro is 10-15 days, and the drug release time in mice subcutaneous is about 20-30 days.
Embodiment 2
[0132] The method step of being processed into sustained-release injection is the same as in Example 1, but the difference is that the contained anticancer active ingredients and their weight percentages are:
[0133] (a) 2-30% heptaplatin, lobaplatin, nedaplatin, oxaliplatin, denaplatin or enloplatin;
[0134] (b) 2-40% bleomycin, daunorubicin, clarithromycin, dactinomycin, amrubicin, arubicin, detorubicin, esorubicin, carrubicin, Rhodobi, Liu Rubi, Medobi, Naimo Rubi, Zorobi, Aroubi, Dorobi, Table Rubi, Idarbi, Pirabi , valrubicin, mitomycin C, actinomycin D, loxoxantrone, mitoxantrone, pyroxantrone, tiloxantrone, or clozocin; or
[0135] (c) 2-30% of cisplatin, carboplatin, omaplatin, dextro-omaplatin, heptaplatin, lobaplatin, nedaplatin, oxaliplatin, denaplatin or enloplatin with 2-40% blemplatin Daunomycin, daunomycin, clarithromycin, dactinomycin, amrubicin, arubicin, detorubicin, ethorubicin, carrubicin, rhodorubicin, rhrubicin , medorubicin, naimorubicin, zorubicin,...
Embodiment 3
[0137] Put 70 mg of polylactic acid (PLGA, 75:25) with a peak molecular weight of 65,000 into a container, add 100 ml of dichloromethane, dissolve and mix well, add 15 mg of carboplatin and 15 mg of 5-FU, re-shake, and vacuum dry to remove organic matter. solvent. Freezing and pulverizing the dried drug-containing solid composition to make micropowder containing 15% carboplatin and 15% 5-FU, and then suspending in physiological saline containing 1.5% carboxymethylcellulose sodium to prepare the corresponding suspension sustained-release injections. The drug release time of the slow-release injection in physiological saline in vitro is 10-15 days, and the drug release time in mice subcutaneous is about 20-30 days.
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