Natural preservative industrialized purification process

A process and chromatographic column technology, which is applied in the field of natural preservative purification process, can solve the problems of low purification yield and achieve the effect of improving yield
CN1876674AActive Publication Date: 2006-12-13SHANGHAI HI TECH BIOENG
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI HI TECH BIOENG
Publication Date
2006-12-13

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Abstract

The invention discloses the purification technology of streptococcus lactis. The method comprises the ion exchange and backward high efficiency liquid chromatography. The recovery ratio is above 50%, and the purity displayed by HPLC is 98%.
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Description

technical field

[0001] The invention relates to a natural preservative purification process, in particular to an industrial purification process of nisin. Background technique

[0002] Nisin, also known as lactin or nisin, is called Nisin in English. It is a small peptide with strong bactericidal effect synthesized and secreted by certain lactococcus in N-type serum during the metabolic process. Nisin can inhibit the growth and reproduction of most Gram-positive bacteria and their spores, such as Staphylococcus, Streptococcus, Clostridium and Bacillus, especially Staphylococcus aureus and Streptococcus hemolyticus , Botox effect is obvious. In addition, Nisin can also work with some complexing agents (such as EDTA or citric acid), but only some Gram-negative bacteria are sensitive to it. Nisin is used in food preservation and cosmetics, but its purity is low. If it is to be used further as medicine, the problem of its purity must be solved.

[0003] J.Meghrous et al. hav...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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