Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Electrochemical cross-linking process for surface modification of biological material

A biomaterial and surface modification technology, applied in the field of biomedical materials, can solve the problems of the influence of the material body structure, the complex operation process, the expensive equipment and other problems, to improve the anticoagulant performance, the process is simple, and the reproducibility is good. Effect

Inactive Publication Date: 2007-01-03
HARBIN INST OF TECH
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many pretreatment methods for artificial blood vessels, they all have problems such as expensive equipment, influence on the structure of the material body, and complicated operation processes, making it difficult to be widely used.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Electrochemical cross-linking process for surface modification of biological material
  • Electrochemical cross-linking process for surface modification of biological material
  • Electrochemical cross-linking process for surface modification of biological material

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0015] Specific embodiment 1: This embodiment is achieved in this way: a, soak the biological material in an organic solvent, ultrasonically clean it, and dry it; b, coat perfluorosulfonic acid on the surface of the biological material; c, prepare polyvinyl alcohol, A mixed solution of diazo resin and biologically active substances, and apply it on the surface of the biological material; d, after drying, irradiate the polymer coating with ultraviolet light, and make the polymer in the coating covalently react through photochemical reaction bonded crosslinks.

[0016] In this embodiment, the biological material can be artificial blood vessels of various calibers made of various materials including expanded polytetrafluoroethylene, or blood catheters of various calibers made of various materials, polymer Membranes or porous scaffolds, and biomedical devices of various shapes made of materials such as glass, ceramics, silicon, various metals or various polymers, preferably polyte...

specific Embodiment approach 2

[0021] Specific implementation mode two: this implementation mode is realized in this way:

[0022] (1) Artificial blood vessel pretreatment: ultrasonically clean the artificial blood vessel in absolute ethanol for 1-300 minutes, and dry at 10-150° C. for 0.1-24 hours.

[0023] (2) The artificial blood vessel is perfused with 0.01-30 wt% perfluorosulfonic acid solution, soaked for 1-300 minutes, and dried.

[0024] (3) Prepare a mixed aqueous solution of polyvinyl alcohol, diazo resin and heparin, perfuse the dried artificial blood vessel, and let it dry.

[0025] (4) The artificial blood vessel is irradiated with ultraviolet light, and covalent bond cross-linking occurs between polymers in the coating through photochemical reaction.

[0026] In step (1) of this embodiment, the ultrasonic time is preferably 30 minutes, the drying temperature is preferably 60° C., and the drying time is preferably 0.5 hour.

[0027] In step (2) of this embodiment, the concentration of the per...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Mwaaaaaaaaaa
Login to View More

Abstract

The present invention provides one photochemical crosslinking process for surface modification of biological material for reaching excellent blood compatibility and tissue compatibility. The photochemical crosslinking process includes the following steps: 1. ultrasonic cleaning artificial implant in organic solvent and drying; 2. painting the surface of biological material with fluorosulfuric acid; 3. compounding mixture solution of polyethylene alcohol, diazo resin and active biological matter, and painting the mixture solution to the surface of biological material; and 4. irradiating the dried polymer coating for photochemical reaction to reach covalent bond crosslinking of the polymer in the coating.

Description

Technical field: [0001] The invention belongs to the field of biomedical materials, and relates to a method for modifying and modifying the surface of an artificial implant with photochemical crosslinking so as to have good blood compatibility and tissue compatibility. Background technique: [0002] Biocompatibility, including hemocompatibility and tissue compatibility, is a basic requirement for the application of biomaterials. In addition to designing and manufacturing new materials with excellent performance, surface chemical treatment (surface grafting of macromolecules or groups), surface physical modification (plasma, ion implantation or ion beam) and biological modification of traditional materials It is the most effective way to improve the biocompatibility of biomaterials. Using cytology and molecular biology methods, proteins, cell growth factors, enzymes, and peptides can be immobilized on the surface of existing materials, and a new generation of molecular bioma...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/50
Inventor 戴志飞马艳邢雷刘萌彭涛
Owner HARBIN INST OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com