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Glossy ganoderma spore oil and its supercritical prepn process

A technology of Ganoderma lucidum spore oil and Ganoderma lucidum spores, which can be used in medical formulas, medical preparations containing active ingredients, plant raw materials, etc. It can solve the problems of long extraction time, high extraction pressure, shutdown, etc., and achieve high purity and good stability Effect

Inactive Publication Date: 2007-03-21
吴逸芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 2. Powder leakage from the filter plate of the extraction kettle is not considered
CO 2 Supercritical extraction is a high-pressure equipment, and the blockage of the pipeline will cause the pressure to rise abnormally and shut down
Because the particle size of Ganoderma lucidum spores is only 10 μm, they are even finer after breaking the wall, and the filter plate of the supercritical extraction kettle has a pore size of about 20-25 μm. The fine powder enters the pipeline through the filter plate, which not only affects the purity of the spore oil, the color of the oil becomes darker, and there are a large number of spore fragments under the microscope, but also blocks the pipeline
[0006] 3. The extraction conditions are not fully optimized
If both are taken into account at the same time, the conditions required by the above patents need to be higher extraction pressure (35--40MPa), and the extraction time is generally 4--30 hours. The existing supercritical pilot test and large-scale production equipment in China It is difficult to meet the requirements, it is easy to leak, and the service life of the equipment will be shortened; due to the consideration of both at the same time, the yield of oil is acceptable, but the content of triterpenoids is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 Get 5 kg of Ganoderma lucidum spores, put them into an ultrafine pulverizer, pass cooling water, and ultrafinely pulverize them into about 300 meshes. Get the ultrafinely pulverized Ganoderma lucidum spore powder and add 5% pregelatinized starch, mix well, and put into a dry press granulator to make 18-mesh granules, and put them into supercritical CO 2 In the extraction kettle, put the filter paper pulping plate into the filter plate in the extraction kettle, extraction pressure 25MPa, temperature 35°C, extraction for 60 minutes; then use 95% ethanol as entrainer, add 250g, extraction for 60 minutes; separation kettle 1 , separation pressure 8MPa, temperature 45°C; separation kettle 2, separation pressure 5.5MPa, temperature 30°C, release the extract from the bottom of the separation kettle to obtain a light yellow oily liquid with a special smell, and recover the entrainer under reduced pressure, and remove it by centrifugation at 15000rpm After miscellan...

Embodiment 2

[0029] Embodiment 2 Get 5 kg of Ganoderma lucidum spores, put them into a Bailey ultrafine pulverizer, pass through cooling water, and ultrafinely pulverize them into 300 meshes, take the ultrafine pulverized Ganoderma lucidum spore powder and add 8% pregelatinized starch, mix evenly, Put it into a dry press granulator to make 12-mesh granules, put in supercritical CO 2In the extraction kettle, put the filter paper pulping plate into the extraction kettle for extraction pressure 30MPa, temperature 40°C, extract for 90 minutes; then add 300g of methanol as entrainer. Extract for 30 minutes; Separation kettle 1, separation pressure 8.5MPa, temperature 50°C; Separation kettle 2, separation pressure 6MPa, temperature 30°C, release the extract from the bottom of the separation kettle to obtain a light yellow oily liquid with a special smell, which is recovered under reduced pressure Entrainer, after 15000rpm centrifugal removal of impurities, removes moisture by anhydrous sodium su...

Embodiment 3

[0030] Embodiment 3 Take 5 kg of Ganoderma lucidum spores, put them into a superfine pulverizer, pass cooling water, and superfinely pulverize them into about 300 meshes. Take the superfine pulverized Ganoderma lucidum spore powder and add 10% pregelatinized starch, mix well, and put into a dry press granulator to make 16-mesh granules, and put them into supercritical CO 2 In the extraction kettle, put absorbent cotton and filter paper into the filter plate in the extraction kettle, extract at a pressure of 28MPa, at a temperature of 40°C, and extract for 120 minutes; then use ethyl acetate as an entrainer, add 1000g of extraction for 45 minutes; separation kettle 1, separate Pressure 8MPa, temperature 45°C; separation kettle 2, separation pressure 6MPa, temperature 35°C, supercritical fluid containing Ganoderma lucidum spore oil enters the separation kettle, separation kettle 1, separation pressure 8MPa, temperature 50°C; separation kettle 2, separation pressure 6MPa , the te...

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PUM

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Abstract

The present invention discloses one kind of glossy ganoderma spore oil, and belongs to the field of Chinese medicine technology. The glossy ganoderma spore oil is measured to contain total triterpene in 25-35 % and unsaturated fatty acids in 60-80 %, and has density of 0.85-1.0, refractive index at 25 deg.c of 1.45-1.50, and acid value of 15-25. The present invention also discloses the supercritical preparation process of the glossy ganoderma spore oil, and the preparation process has high extracting rate, and is favorable to the stability of the glossy ganoderma spore oil and suitable for industrial production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine ganoderma lucidum spore oil, which belongs to the field of traditional Chinese medicines. Also involved in the CO of the Ganoderma lucidum spore oil 2 Supercritical extraction preparation method. Background technique [0002] Ganoderma lucidum is a fungus of the genus Ganoderma lucidum belonging to the family Polyporaceae. It has a long history of medicinal use in my country. The germ cells of Ganoderma lucidum are the seeds of Ganoderma lucidum. Recent studies have shown that Ganoderma lucidum spores have significant pharmacological effects in anti-tumor, immune regulation, anti-radiation, regulating nerves, protecting the cardiovascular system, regulating the respiratory system, and promoting digestion. Ganoderma lucidum The spores mainly contain active ingredients such as triterpenoids, unsaturated fatty acids, polysaccharides, nucleosides, organic germanium, sterols, alkaloids, etc. In 1982, K...

Claims

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Application Information

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IPC IPC(8): A61K36/074
Inventor 吴逸芳
Owner 吴逸芳
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