Low virulent strain of recombinant newcastle disease lasota vaccine expressing HA protein of avian influenza-H5 virus

A technology of avian influenza virus and attenuated vaccine, which is applied to a method and the recombinant Newcastle disease LaSota attenuated vaccine strain in the field of preparation and prevention of poultry, HA and rLa, which can solve the problems of inconvenient use, high manufacturing cost, and unrealized wide application.
CN1942578BActive Publication Date: 2011-06-15HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Publication Date
2011-06-15

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Abstract

Low virulent strain of recombinant newcastle disease LaSota vaccine expressing wild or mutant hemagglutinin(HA)protein of avian influenza-H5 virus is provided. Particularly, Low virulent strains of recombinant newcastle disease LaSota vaccine are rLasota-H5wtHA and rLasota-H5mutHA. The present invention also provides method for preparing said low virulent strain, and the use of such strain in preparing vaccine for preventing avian influenza.
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Description

technical field

[0001] The present invention relates to the field of recombinant virus vaccines, more specifically, the present invention relates to a recombinant Newcastle disease LaSota attenuated vaccine strain expressing a gene encoding wild-type or mutant avian influenza virus H5 subtype hemagglutinin (HA) protein, more specifically Specifically, the recombinant Newcastle disease LaSota attenuated vaccine strains are rLasota-H5wtHA and rLasota-H5mutHA. The invention also discloses a method for preparing the recombinant Newcastle disease LaSota attenuated vaccine strain and the application of the recombinant Newcastle disease LaSota attenuated vaccine strain in preparing vaccines for preventing bird flu. Background technique

[0002] Newcastle disease virus (NDV) is a non-segmented single-stranded negative-sense RNA virus. As an important member and model virus of the Paramyxoviridae family, it has been deeply studied. Recombinant NDV has extraordinary advantages as a l...

Claims

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