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Cataplasma of bulleyaconitine A

A technology of aconitin and cataplasm, applied in the direction of anti-inflammatory agents, non-central analgesics, organic active ingredients, etc., which can solve the problems of biocompatibility, affinity, breathability, poor sweat resistance, continuous patching, etc. If it is applied on the skin for a long time, it is prone to skin discomfort and other problems, and achieves the effect of good moisturizing performance, favorable transdermal absorption and fast onset of action

Inactive Publication Date: 2007-05-23
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The patent of Publication No. CN1507866A relates to a transdermal patch of aconitin. The main feature of the patch is that it has a controlled release effect and can release the drug continuously for 1 to 12 minutes. Each patch of the transdermal patch contains the main drug Aconitum aconitum A content of 0.1 mg to 100 mg, because the transdermal patch has poor biocompatibility, affinity, air permeability, and sweat resistance to the skin, and is prone to allergies; and the transdermal patch has a slow onset of action, and it takes a long time to apply it continuously on the skin. Longer, more irritating to the skin, prone to skin discomfort symptoms

Method used

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  • Cataplasma of bulleyaconitine A
  • Cataplasma of bulleyaconitine A
  • Cataplasma of bulleyaconitine A

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Backing layer: non-woven fabric

[0064] Cover lining: polyester film

[0065] The composition of the medicated ointment layer is as follows by weight:

[0066] Aconitin (micronized) 0.05g

[0067] Gelatin 1.3g

[0068] Tragacanth Gum 1.8g

[0069] Macrogol-400 2.2g

[0070] Polyacrylic acid 1.8g

[0071] Glycerin 1.8g

[0072] Zinc oxide 0.13 g

[0073] Azone 1.0g

[0074] borneol 0.05g

[0075] Preparation method: Micronize and pulverize aconitin, weigh gelatin and tragacanth gum according to the prescription, add 65 grams of water, heat in a water bath to dissolve, mix polyacrylic acid, glycerin and zinc oxide evenly, add the above glue , stir and mix evenly, then add polyethylene glycol-400 to disperse borneol and aconitin, and finally add azone to obtain a paste. Then spread it evenly on the non-woven fabric, cover it with a polyester film, and cut it to get 10,000 pieces of gentianin cataplasm.

Embodiment 2

[0077] Backing layer: non-woven fabric

[0078] Cover lining: aluminum foil-polyethylene composite film

[0079] The composition of the medicated ointment layer is as follows by weight:

[0080] Aconitine 0.06g

[0081] Sodium Polyacrylate 2.0g

[0082] Gelatin 1.5g

[0083] Polyvinyl alcohol 2.5 grams

[0084] Glycerin 2.5g

[0085] Zinc oxide 0.2 g

[0086] Azone 0.3g

[0087] Propylene Glycol 1.0g

[0088] Menthol 0.06g

[0089] Preparation method: prepare aconitin solid dispersion, pulverize; weigh gelatin, sodium polyacrylate and polyvinyl alcohol according to the prescription amount, add 72 grams of water to make swelling, stir and mix evenly, mix glycerin and zinc oxide evenly, add the above In the swelling liquid, stir and mix evenly, then add the suspension liquid in which menthol and aconitin are dispersed with propylene glycol and azone to obtain a paste. Then spread it evenly on the non-woven fabric, cover it with a polyester film, and cut it into a suita...

Embodiment 3

[0091] Backing layer: non-woven fabric

[0092] Lid lining: Polyethylene film

[0093] The composition of the medicated ointment layer is as follows by weight:

[0094] Aconitin (micronized) 0.07g

[0095] Sodium polyacrylate 1.3g

[0096] Carbomer 934p 0.1g

[0097] Glycerin 5.3g

[0098] Propylene Glycol 1.4g

[0099] Kaolin 1.3g

[0100] Citric acid 0.04g

[0101] Aluminum trichloride 0.08 g

[0102] Menthol 0.07g

[0103] Preparation method: Micronize and pulverize aconitin, weigh sodium polyacrylate, carbomer 934p and add 55 grams of purified water to swell according to the prescription amount, add aluminum trichloride, stir and mix evenly; 2. Mix glycerin and kaolin and add to 1; 3. Use propylene glycol to add menthol and aconitin dispersion to 2; 4. Finally add citric acid, stir and mix evenly to obtain a paste. Then spread it evenly on the non-woven fabric, cover it with a polyethylene film, and cut it into pieces of suitable size to obtain 10,000 pieces of g...

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Abstract

The invention relates to an external agent-bab agent of wild aconite root element, wherein it is formed by wild aconite root element and some findings. And it comprises liner layer, drug paste and cover lliner layer. The drug paste comprises wild aconite root element, adhesive, stuff, accelerator, and humectant, while each unit comprises 0.5-30mg wild aconite root element. The invention comprises quick effect, better humidity property and ventilation. It has little excitation on skin.

Description

technical field [0001] The present invention relates to an external dosage form of orientalin which can be used for treating various pains and has certain anti-inflammation, antipyretic and local anesthetic effects-a cataplasm. Background technique [0002] Catapult is an external preparation that dissolves or mixes drugs in a natural or synthetic water-soluble polymer matrix and spreads them on the backing material for sticking on the skin. It can act systemically or locally through transdermal absorption. It is also a transdermal drug delivery preparation, and its prototype is "poultica". Due to the rapid development of modern fine chemical industry and polymer material science, more excipients with superior performance have been provided for pharmacy. Therefore, cataplasm was first successfully developed by Japan in the 1970s. Up to now, a large number of cataplasms have been launched in developed countries such as Europe, America and Japan, and are well received by doc...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/439A61P29/00A61K31/045
Inventor 丁江生张国丽
Owner KPC PHARM INC
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