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Nanometer mesoporous silicon based xerogel hemostatic material and its preparing method and use

一种纳米介孔、止血材料的技术，应用在化学仪器和方法、氧化硅、血液疾病等方向，能够解决覆盖、止血效果欠佳、使用过程复杂、组织热灼伤等问题，达到止血效果好、提高效果、加速愈合的效果

Inactive Publication Date: 2007-05-30
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these materials have a certain hemostatic effect, they have the following significant problems: the coverage of large-area wounds, complex wounds, and multiple wounds, and the hemostatic effect are not good; there are too many materials, and the use process is relatively complicated, which is not conducive to on-site first aid, etc.
Mineral zeolite hemostats are not biodegradable, and they exist in the body as "foreign matter" for a long time after use, and there is an obvious exothermic reaction after the material absorbs water, and tissue thermal burns will occur when used on large bleeding wounds

Method used

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  • Nanometer mesoporous silicon based xerogel hemostatic material and its preparing method and use
  • Nanometer mesoporous silicon based xerogel hemostatic material and its preparing method and use
  • Nanometer mesoporous silicon based xerogel hemostatic material and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Weigh 10 g of tetraethyl orthosilicate, dissolve in a mixed solvent of 5.4 g of deionized water and 2 g of absolute ethanol, mix and stir for 10 minutes; add 1N hydrochloric acid dropwise, keep the pH value at 3, and continue stirring for 2 hours. The sol was injected into a polyethylene mold and sealed for aging for 2 days, and then the temperature was gradually raised to 180° C. for 4 hours. Under an optical microscope, the synthesized silicon-based xerogel is a smooth, transparent block (see Figure 1). Further nitrogen adsorption-desorption test results show that the calcium-free silicon-based xerogel material has a pore size of 3nm and a specific surface area of ​​670m2 / g, denoted as L-1.

Embodiment 2

[0042] Weigh 10g ethyl orthosilicate, 3.36g trimethyl phosphate and 2.67g calcium chloride, dissolve in a mixed solvent of 8g deionized water and 8g absolute ethanol, mix and stir for 10 minutes at room temperature; add dropwise 1N hydrochloric acid, keep the pH value at 4, and keep stirring for 2 hours. The sol was injected into a polyethylene mold and aged in a sealed environment for 2 days, and then freeze-dried for 10 hours. The sample was put into a corundum crucible, heated to 700°C with a program-controlled electric furnace, cooled naturally, ground through a 150-mesh standard sieve, and sealed for later use. The powder is a calcium-containing silicon-based xerogel hemostatic material. Using X-ray diffractometer (XRD), scanning electron microscope (SEM) and BET method to test the phase composition, morphology, pore size and pore distribution of the prepared powder respectively, the results are shown in Figure 2, Figure 3, Figure 4, Figure 5. The results show that the...

Embodiment 3

[0044] Weigh 15g ethyl orthosilicate, 2.16g trimethyl phosphate and 1.71g calcium chloride, dissolve in a mixed solvent of 8g deionized water and 8g absolute ethanol, mix and stir for 10 minutes at room temperature, slowly drop Add 1N hydrochloric acid to keep the pH at 6, and continue stirring for 2 hours. The sol was injected into a polyethylene mold and aged in a sealed environment for 2 days, and then freeze-dried for 10 hours. The sample was put into a corundum crucible, heated to 700°C with a program-controlled electric furnace, cooled naturally, ground through a 150-mesh standard sieve, and sealed for later use. The powder is a calcium-containing silicon-based xerogel hemostatic material. Nitrogen adsorption-desorption experiment The powder has a pore size of 50nm and a specific surface of 650m 2 / g of calcium-containing silica-based xerogel, denoted as L-3.

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Abstract

The invention discloses a making method and application of nanometer dielectric-hole silicon based dried gel styptic material, which is characterized by the following: the material possesses nanometer hole (1-50nm) and high specific surface area (100-1400m2 / g), whose chemical composition is adjustable with excellent biological decomposition.

Description

technical field [0001] The invention relates to a hemostatic material and its preparation method and application, in particular to a silicon-based xerogel hemostatic material with a nano-mesoporous structure and its preparation method and application. technical background [0002] Hemorrhage is a complication that can occur in any trauma, and is one of the main causes of threatening human life. At the same time, rapid and effective hemostasis is also an important part of clinical operations and first aid for war wounds. According to incomplete statistics, at present, about 500 tons of various hemostatic drugs are used clinically in my country every year. Therefore, finding effective hemostatic materials suitable for wound healing in various surgical operations and wound healing in field first aid has always been a hot spot of research at home and abroad. [0003] Traditional wound hemostatic materials are mainly first aid kits, four-head bands, tourniquets and bandages, as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/44A61L15/62A61L15/64
CPCC01B33/16A61L15/18C01B33/163A61L2400/12A61L2400/04A61L26/0004A61P7/04
Inventor 刘昌胜袁媛
Owner EAST CHINA UNIV OF SCI & TECH
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