Selecting animals for desired genotypic or potential phenotypic properties

a genotypic or potential phenotypic technology, applied in the field of methods of selecting animals, can solve the problems of negative genetic correlation between reproductive capacity and production traits, and is ever considered feasible to employ this elusive genetic characteristic, and achieve the effects of reducing back fat, enhancing teat number, and increasing muscle mass

Inactive Publication Date: 2006-02-16
LEIGE UNIV OF +3
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  • Summary
  • Abstract
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Benefits of technology

[0090] Sires of two commercial lines were genotyped for the mutation. Shortly after birth, the number of teats was counted in all piglets. Piglet counts ranged from 12 to 18 teats and included 4477 individuals from 22 sires. A statistical analysis of teat number in piglets was performed by accounting for the following effects: 1) genetic line (lines A and B), 2) genotype of the sire for the mutation (QQ, Qq or qq) and 3) sex of the piglet (male/female). Analysis of variance was performed using Proc Mixed (SAS), assuming normality of dependent variable teat number. Estimates of some contrasts are given in Table 4.
[0091] The effect of genotype on teat number in piglets is −0.28 teats. This effect is opposite to the one described by Hirooka et al. 2001. An effect of genetic line could not be demonstrated. The sex of the piglet had a significant effect on teat number with female pigs having an average of 0.05 teat more than males. Mean values per genotype and per line are given in Table 5. TABLE 4Analysis of variance of teat number counted in pigletsof two commercial lines (n = 4477).EffectP-valueContrastEstimate(s.e)Genotype of sire<0.001QQ-qq−0.28 (0.05)Qq-qq−0.22 (0.03)Genetic line0.081Sex0.043M-F−0.05 (0.03)
[0092]TABLE 5Descriptive statistics of teat number counted in piglets oftwo commercial lines (n = 4477) descen...

Problems solved by technology

One of the major problems in breeding programs of domestic animals is the negative genetic correlation between reproductive capacity and production traits.
The phenomenon of genetic or par...

Method used

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  • Selecting animals for desired genotypic or potential phenotypic properties
  • Selecting animals for desired genotypic or potential phenotypic properties
  • Selecting animals for desired genotypic or potential phenotypic properties

Examples

Experimental program
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example 3

The Mutation has an Effect on Teat Number

[0090] Sires of two commercial lines were genotyped for the mutation. Shortly after birth, the number of teats was counted in all piglets. Piglet counts ranged from 12 to 18 teats and included 4477 individuals from 22 sires. A statistical analysis of teat number in piglets was performed by accounting for the following effects: 1) genetic line (lines A and B), 2) genotype of the sire for the mutation (QQ, Qq or qq) and 3) sex of the piglet (male / female). Analysis of variance was performed using Proc Mixed (SAS), assuming normality of dependent variable teat number. Estimates of some contrasts are given in Table 4.

[0091] The effect of genotype on teat number in piglets is −0.28 teats. This effect is opposite to the one described by Hirooka et al. 2001. An effect of genetic line could not be demonstrated. The sex of the piglet had a significant effect on teat number with female pigs having an average of 0.05 teat more than males. Mean values p...

example 1

REFERENCES WITH EXAMPLE 1

[0095] AMARGER, V., M. NGUYEN, A. S. VAN LAERE, C. NEZER, M. GEORGES, and L. ANDERSSON, 2002. Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs. Mammalian Genome 13:388-398. [0096] ANDERSSON, L. 2001. Genetic dissection of phenotypic diversity in farm animals. Nature Reviews Genetics 2:130-138. [0097] ARDLIE, K. G., L. KRUGLYAK, and M. SEIELSTAD, 2002. Patterns of linkage disequilibrium in the human genome. Nat. Rev. Genet. 3:299-309. [0098] BLOTT, S., J.-J. KIM, S. MOSIO, A. SCHMIDT-KÜNTZEL, A. CORNET, P. BERZI, N. CAMBISANO, C. FORD, B. GRISART, D. JOHNSON, L. KARIM, P. SIMON, R. SNELL, R. SPELMAN, J. WONG, J. VILKKI, M. GEORGES, F. FARNIR, and W. COPPIETERS (2002). Molecular dissection of a QTL: a phenylalanine to tyrosine substitution in the transmembrane domain of the bovine growth hormone receptor is associated with a major effect on milk yield and composition. Genetics, in the press. [0099] DARVASI, A. 1998. Experimental strategie...

example 2

REFERENCES AND NOTES WITH EXAMPLE 2

[0120] 1. C. Nezer et al., Nature Genet. 21, 155-156 (1999). [0121] 2. J.-T. Jeon et al., Nature Genet. 21, 157-158 (1999). [0122] 3. D. J. De Koning et al., Proc. Natl. Acad. Sci. U.S.A. 97, 7947-7950 (2000). [0123] 4. H. Thomsen, J. C. M. Dekkers, H. K. Lee, and M. Rothschild, paper presented at the 7th World Congress of Genetics Applied to Livestock Production, Montpellier, France 2002. [0124] 5. C. Nezer et al., submitted (2003). [0125] 6. J. R. Florini, D. Z. Ewton, and F. J. Mcwade, Diabetes Rev. 3, 73-92 (1995). [0126] 7. V. Amarger et al., Mammalian Genome 13, 388-398 (2002). [0127] 8. G. J. Evans et al., Genetics in press (2003). [0128] 9. QTL genotyping of the Pietrain / Large White, Wild Boar / Large White, and Hampshire / Landrace crosses by marker-assisted segregation analysis was performed as described (5). Briefly, the likelihood of the pedigree data was computed under two hypothesis: H0, postulating that the corresponding boar was homozyg...

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Abstract

The invention relates to methods to select animals, such as mammals, in particular, domestic animals such as breeding animals or animals destined for slaughter, for having desired genotypic or potential phenotypic properties, in particular, related to muscle mass and/or fat deposition or, in the case of mammals, to teat number. The invention provides a method for selecting an animal for having desired genotypic or potential phenotypic properties comprising testing the animal, a parent of the animal or its progeny for the presence of a nucleic acid modification affecting the activity of an evolutionary conserved CpG island, located in intron 3 of an IGF2 gene and/or for the presence of a nucleic acid modification affecting binding of a nuclear factor to an IGF2 gene.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation of PCT International Patent Application No. PCT / EP04 / 000149, filed on Jan. 9, 2004, designating the United States of America, and published, in English, as PCT International Publication No. WO 2004 / 063386 A2 on Jul. 29, 2004, which application claims priority to European Patent Application Serial No. 03075091.3 filed on Jan. 10, 2003, the contents of the entirety of each are incorporated herein by this reference.TECHNICAL FIELD [0002] The invention relates to methods to select animals, such as mammals, in particular, domestic animals such as breeding animals or animals destined for slaughter for having desired genotypic or potential phenotypic properties, in particular, related to muscle mass and / or fat deposition or, in the case of mammals, to teat number. Herein, a domestic animal is defined as an animal being purposely selected or having been derived from an animal having been purposely selected for...

Claims

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Application Information

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IPC IPC(8): A01K67/027C12Q1/68A61K48/00
CPCC12Q1/6876C12Q2600/124C12Q2600/154C12Q2600/156C12Q2600/158C12Q2600/172A61P21/00A61P3/04
Inventor ANDERSSON, LEIFANDERSSON, GORANGEORGES, MICHELBUYS, NADINE
Owner LEIGE UNIV OF
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