The invention is applicable to the technical field of pacemaker modeling, and provides a biological pacemaker model building method and terminal equipment. The method comprises: constructing an inward rectifying potassium current ion channel model, constructing a pacing current ion channel model, reconstructing according to the inward rectifying potassium current ion channel model, the pacing current ion channel model and pre-existing models of other ion channels on the ventricular myocyte membrane Generate a biological pacemaker model, judge whether the electrophysiological characteristics of the biological pacemaker model are qualified, and determine whether the biological pacemaker model is successfully constructed if the electrophysiological characteristics are judged to be qualified. After adopting the above scheme, the application process of the biological pacemaker is accelerated, which has important guiding significance for the clinical application of the biological pacemaker.