The invention discloses a manufacturing process of a sponge-free mattress. The manufacturing process comprises the following steps: (1) selecting raw materials, namely, selecting face cloth, soybean fiber cotton, polyester fiber cotton and a plurality of pieces of lining cloth; (2) forming a shell fabric, namely, carrying out quilting on the face cloth, the soybean fiber cotton, the polyester fiber cotton and the lining cloth by adopting a quilting machine, thus manufacturing a composite shell fabric; (3) carrying out cutting and sizing, namely, according to the needed manufacturing size of the mattress, cutting the composite shell fabric, and carrying out sewing and forming through a sewing machine; and (4) carrying out spring manufacturing and assembling, namely, manufacturing springs through a spring machine, and carrying out assembling for forming a net on the springs according to the size of the mattress. For the manufacturing process of the sponge-free mattress, the polyester fiber cotton and the soybean fiber cotton are adopted for replacing sponge in the mattress, through the reform and innovation of the manufacturing process, the service life of the mattress is greatly prolonged, and the potential safety hazards caused to the body health by the traditional mattress adopting the sponge technology are eliminated.