The invention discloses an impedance self-adaptive laser diode driver, and belongs to the technical field of electronic equipment. The impedance self-adaptive laser diode driver mainly comprises a current setting module (1), an amplitude limiting setting module (2), a power output module (3), a load judgment module (4), a delay compensation module (5), a voltage tracking module (6), a power-off protection module (8), a front panel (14) and the like. When the driver works, the driver can actively adapt to the load change, and has the advantages of high efficiency, wide load application range, high safety, high reliability and the like.