Pharmaceutical composition containing caffeoylquinic acids
A technology of caffeoylquinic acid and composition, applied in the field of functional health care products or cosmetics, medicine, composition containing natural plant extracts or monomers, capable of solving problems without providing scientific basis, without hint or try and other questions
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Embodiment 1
[0210] Example 1 Capsules
[0211] Take 5g of Radix Paeoniae Rubra, crush it into a coarse powder, add 75% ethanol to reflux and extract three times, the first and second times each for 2 hours, and the third time for 1 hour, combine the extracts, concentrate under reduced pressure to about 400ml, and extract three times with n-butanol , 300ml at a time, merge the n-butanol extract, concentrate under reduced pressure to no n-butanol smell, add 200ml of water, heat to dissolve, filter, and the filtrate is spray-dried to obtain Extract I for subsequent use;
[0212] Get one part of extract, get Flos Lonicerae extract (chlorogenic acid content is not less than 50%) 1g, add starch, magnesium stearate, mix, pack in the hard capsule. After testing, each capsule contains 500mg of chlorogenic acid and 100mg of paeoniflorin.
Embodiment 2
[0213] Example 2 tablet
[0214] Take 5 kg of coffee beans, extract with 95% ethanol, dissolve the extract in water and extract with petroleum ether, ethyl acetate and n-butanol respectively to obtain petroleum ether, ethyl acetate and n-butanol. The ethyl acetate part was subjected to silica gel column chromatography and MCI column chromatography to obtain 8 g of dicaffeoyloxyquinic acid and 4 g of quinic acid, respectively. Then 100 mg of dicaffeoyloxy-quinic acid was dissolved in 1000 ml of water to make a 0.1% aqueous solution, heated and dissolved, mixed evenly, sealed in a medicine bottle, sterilized to produce a product, and the extract II was obtained for subsequent use.
[0215] Take two parts of extract I and one part of extract II of Example 1, add low-substituted hydroxypropyl cellulose, magnesium stearate, starch, microcrystalline cellulose, and granulate according to the standard granulation and tableting process. After testing, it contains dicaffeoylquinic acid...
Embodiment 3
[0216] Embodiment 3 soft capsules
[0217] Get half part of the extract I and five parts of the extract II of Example 1, add starch and magnesium stearate, mix well, and make soft capsules according to the standard process. After testing, each capsule contains 500mg of dicaffeoylquinic acid and 50mg of paeoniflorin.
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