Check patentability & draft patents in minutes with Patsnap Eureka AI!

Bioactivity, porous nanometer titanium oxide ceramic used for sclerous tissues restoration and its prepn. method

A nano-titanium oxide and biologically active technology, applied in the field of biomedical engineering, can solve problems such as high cost, infection, and limited use of low-income patients, and achieve good repair and hard tissue repair effects

Inactive Publication Date: 2008-10-08
SICHUAN UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main problem faced by the bioactive material is: after implantation, the particles produced by the degradation or wear of the implant material may cause infection at the implant site; at the same time, the cost of the materials used is high, and the hydroxyapatite The market price is at least 5,000 RMB / kg; the cost of bioactive glass and bioactive metal is higher, thus limiting the use of low-income patients
[0003] At present, the inventor has developed bioactive titanium oxide ceramics for hard tissue repair and its preparation method, and has obtained the Chinese patent right, patent number ZL200310104134.X. The bioactive titanium oxide ceramics prepared by this method have microscopic penetrating pores , the grain size of the bioactive titanium oxide ceramics is between 0.1 and 1 micron, and the micropore size between the grains is 0.1 to 3 microns; although the bioactive titanium oxide ceramics provided by the above invention have microscopic penetrating pores, but Macroscopically, there are no penetrating pores, so bone tissue cannot grow into the material, and can only form a bioactive combination with bone tissue on the surface of the implant material

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bioactivity, porous nanometer titanium oxide ceramic used for sclerous tissues restoration and its prepn. method
  • Bioactivity, porous nanometer titanium oxide ceramic used for sclerous tissues restoration and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Put rutile nano-titanium oxide powder in the container, add 1% by mass of grain growth inhibitor hydroxyapatite to obtain powder, and stir the powder evenly; dissolve the binder polyvinyl alcohol in deionized water Obtain an aqueous solution containing 4%, then add foaming agent hydrogen peroxide in the above-mentioned aqueous solution to obtain a foaming solution containing 2% hydrogen peroxide: then after fully mixing the powder and the foaming solution with a volume ratio of 1: 4, in an oven for 40 After foaming and drying at a temperature of ℃, put it into a muffle furnace for sintering, and raise it to the holding temperature at a heating rate of 50°C / min. At this time, the holding temperature is 1200°C. After holding at the holding temperature for 4 hours, After cooling down to room temperature in the furnace, a biologically active porous nanometer titanium oxide ceramic block with nanometer crystallization is produced. In the biologically active porous nano-titan...

Embodiment 2

[0028] Put anatase nano-titanium oxide powder in the container, add 5% aluminum oxide by mass percentage as a grain growth inhibitor, obtain powder, and stir the powder evenly; dissolve the adhesive polyvinyl alcohol in deionized Obtain an 8% aqueous solution in water, then add foaming agent hydrogen peroxide to the aqueous solution to obtain a foaming solution containing 8% hydrogen peroxide; After foaming and drying at ℃, put it into a muffle furnace for sintering, and raise it to the holding temperature at a heating rate of 50°C / min. At this time, the holding temperature is 600°C. After being kept at the heat preservation temperature for 3 hours, it is cooled to room temperature with the furnace, and a biologically active porous nanometer titanium oxide ceramic block with nanometer crystallization is obtained. In the bioactive porous nano-titanium oxide ceramic block obtained in this example, there are macroscopic penetrating pores with an average pore diameter of 400 micro...

Embodiment 3

[0030] Put the mixed nano-titanium oxide powder of rutile and anatase in the container, add 1% by mass of calcium pyrophosphate as a grain growth inhibitor, and obtain the powder; dissolve the binder polyvinyl alcohol in deionized water Obtain a 1% aqueous solution, and then add the foaming agent hydrogen peroxide into the aqueous solution to obtain a foaming solution containing 1% hydrogen peroxide; then mix the powder and the foaming solution at a volume ratio of 1:3, and then heat it in an oven at 30°C After foaming and drying, put it into a muffle furnace for sintering, and raise it to the holding temperature at a rate of 50°C / min. At this time, the holding temperature is 1000°C; After cooling to room temperature, a biologically active porous nanometer titanium oxide ceramic block with nanometer crystallization is obtained. In the bioactive porous nano-titanium oxide ceramic block obtained in this example, there are macroscopic penetrating pores with an average pore diamet...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
sizeaaaaaaaaaa
Login to View More

Abstract

A bioactive porous nano-titanium oxide ceramic for repairing hard tissue by allowing the bone tissue to grow into it is prepared from the titanium oxide nanoparticles, crystal grain growth inhibitor, adhesive and foaming agent through foaming, drying, shaping and sintering.

Description

1. Technical field [0001] The invention relates to bioactive materials and preparation techniques thereof, in particular to a bioactive porous nano-titanium oxide ceramic for hard tissue repair and a preparation method thereof, belonging to the field of biomedical engineering. 2. Background technology [0002] Bioactive materials for hard tissue repair refer to materials that chemically combine with bone tissue through the formation of a bone-like apatite interface layer after implantation. Currently, bioactive materials widely used in hard tissue repair include hydroxyapatite ceramics, bioactive glass, and surface-modified bioactive metals. These bioactive materials are implanted into the bone, and the chemical combination of bioactivity is realized by forming a bone-like apatite interface layer on the interface between the material and the bone tissue. However, the main problem faced by the bioactive material is: after implantation, the particles produced by the degradati...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/10C04B35/46C04B38/02
Inventor 杨帮成李振声黄毅甘露屈阳顾忠伟张兴栋
Owner SICHUAN UNIV
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com