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Tiopronin amino salt, and its preparing method
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A technology of tiopronin amino acid salt and tiopronin amino acid, which can be used in the preparation of thiols, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as thermal instability, easy oxidative degradation, and instability
Active Publication Date: 2008-11-26
WUHAN WUYAO PHARMA
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Problems solved by technology
[0005] But tiopronin has its major defect, that is, it is very unstable, and it is easy to oxidize and degrade in the presence of water, which affects the curative effect and safety of its clinical treatment.
Moreover, the melting point of tiopronin is relatively low at 96-99°C, so it is also unstable to heat.
The physical and chemical properties of tiopronin directly limit its use in the preparation of various pharmaceutical preparations
Therefore, in order to improve the use effect of tiopronin, many researchers prepare it and other components into a composition, and its use effect is still not good
For example, the invention patent application with publication date of February 23, 2005 and publication number CN1582911A discloses a new freeze-dried powder of tiopronin, which uses tiopronin as an active ingredient and pharmaceutical excipient amino acid to form a drug. Composition, it improves the stability of tiopronin in aqueous solution to a certain extent, and has a certain inhibitory effect on the oxidative degradation of tiopronin, but a considerable part of tiopronin will still be oxidatively degraded
In particular it shows little improvement in the thermal stability of tiopronin
So for a long time, how to solve the problem of easy oxidative degradation and poor thermal stability of tiopronin has always been the subject of research by those skilled in the art
Method used
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Embodiment 1
[0020] Embodiment 1: the preparation of tiopronin arginine salt
[0021] Feeding ratio:
[0022]
[0023] operate:
[0024] Put tiopronin, L-arginine, and ethanol into a 1000ml three-necked reaction flask, stir, heat to 50°C for reflux, and after 3 hours of reflux reaction, filter while hot, and place the filtrate in a refrigerator at 5-10°C to cool and crystallize. After 5 hours, it was filtered to obtain white crystals, which were dried in an oven at 80°C for 6 hours to obtain 196 g of white crystalline solids, yield 94.8%, mp 197-200°C.
[0025] The infrared absorption spectrum data of the sample:
[0034] Put tiopronin and phenylalanine salt into a 1000ml three-necked reaction flask at a ratio of 1:0.8, then add 650ml of ethyl acetate for stirring, heat to reflux at 100°C, and after 3 hours of reflux reaction, filter while hot, and place the filtrate in Cool and crystallize in the refrigerator at 5-10°C. After 5 hours, it was filtered to obtain white crystals, which were dried in an oven at 80° C. for 6 hours to obtain 196 g of white crystalline solids, yield 94.2%, mp 195-200° C.
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Abstract
This invention relates tioproninamino acid salt used to cure chronic hepatitis and its preparation method. Its constitutional formula is shown as follow; R is 1-20 carbon atoms straight chain or branched chain alkyl radical. This invention solves the problem of tiopronin oxidation degradation in water, and volatilization decomposition in heat. The tiopronin in this invention is prepared into amino acid salt, it prevent the tiopronin combining with oxygen, and its oxidation. Medical using substance melting point is improved, so its thermal stability is greatly improved, so its medical effect as effective constituent is greatly improved.
Description
technical field [0001] The invention relates to an amino acid salt used for preparing medicine and a preparation method thereof, in particular to a tiopronin amino acid salt used for treating acute and chronic liver diseases and a preparation method thereof. Background technique [0002] Tiopronin (English name Tiopronin, chemical name: N-(2-mercaptopropionyl) glycine) is a metabolic improvement antidote, its molecular formula: C 5 h 9 NO 3 S, molecular weight: 163.20, structural formula as follows: [0003] [0004] It can activate metabolic enzymes, improve proteinmetabolism, and promote liver function repair. It is mainly used for the treatment of acute and chronic liver diseases. Since the 1990s, my country has successfully developed the API of tiopronin, and after that, various preparations of tiopronin have been listed on the market: including tablets, capsules, aqueous injections and freeze-dried powder injections, etc., which are now widely used Clinically, it...
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