Eye medicine for treating fungal keratitis

A technology for fungal keratitis and ophthalmic medicine, which is applied in the field of ophthalmic medicine for treating fungal keratitis, can solve the problems of lack of supply, poor antibacterial effect of ocular fungi, and high cost, and achieves simple preparation method, obvious curative effect and exact curative effect. Effect

Inactive Publication Date: 2008-12-03
王香兰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although synthetic antifungal drugs have been greatly developed at present, due to the different species of eye infection fungi and other parts of infection fungi, especially the special requirements for eye medications, there is a shortage of antifungal eye drops.
It is reported that in the United States, only one kind of eye drops called Natezhen has been approved by the FDA, but this drug is an imported drug and the supply is scarce, so it is extremely expensive and difficult to promote and use in patients
The domestically produced only fluconazole eye drops (its trade name is "Bufen" or "Jingda"). Research shows that this drug has poor antibacterial effect on ocular fungi, and the treatment effect is not good.

Method used

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  • Eye medicine for treating fungal keratitis
  • Eye medicine for treating fungal keratitis
  • Eye medicine for treating fungal keratitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1, the preparation and detection of the eye medicine for the treatment of fungal keratitis

[0034] 1. Preparation of eye drops

[0035] Get terbinafine hydrochloride (by C 21 h 25 N) 2.5g, hydroxypropyl β-cyclodextrin 35g, dissolved in water for injection, then add 1.0mL of 5% benzalkonium bromide solution and 8g of NaCl, adjust the pH to 4.0-5.5 with 0.1M sodium hydroxide, Finally, add water for injection to make the volume to 1000mL, mix well, filter, and sterilize by flowing steam at 100°C for 30 minutes to obtain transparent eye drops for treating fungal keratitis, which are aseptically divided into 10mL bottles.

[0036] Terbinafine is insoluble in water and has certain irritation. Dissolution tests are carried out with various organic solvents such as acetone, ethanol, DMSO, methanol and chloroform. As a result, acetone, ethanol and DMSO dissolve the best, but they are not easy to use eyes. In the prescription research, different ratios of borax an...

Embodiment 2

[0063] Embodiment 2, the preparation of the eye medicine for the treatment of fungal keratitis

[0064] Get terbinafine hydrochloride (by C 21 h 25 N meter) 5g, β-cyclodextrin 25g, dissolved in water for injection, adjust pH to 4.0-5.5 with 0.1M sodium hydroxide, add water for injection to make up to 1000mL, mix well, filter, and circulate steam at 100°C Sterilize for 30 minutes to obtain transparent eye drops for treating fungal keratitis, which are aseptically divided into 10 mL bottles.

[0065] Detect with the method identical with embodiment 1, test result shows that every test result of ophthalmic medicine of the present invention all meets the regulations.

Embodiment 3

[0066] Embodiment 3, drug effect, pharmacology and toxicology analysis of eye drops of the present invention

[0067] 1. Efficacy test

[0068] Isolate pathogenic fungus specimens from the eyes of patients with fungal keratitis, and dilute to 2-5×10 after passage identification 6 / mL concentration, inoculate the corneal stromal layer of rabbit eyes, the specific method is: select 30 rabbits of 1.5 kg, divide into 6 groups, 5 in every group (total 10 eyes), wherein three groups are treatment groups, use three groups respectively. Terbinafine eye drops of different concentrations were used for treatment; the other three were control groups, one of which was treated with 5% natezhen as a positive control, and the remaining two groups were solvent eye drops negative control group and model control without treatment. Group. The observation results after 2 days of treatment are as follows Figure 1A-1B As shown, the observation results after 12 days of treatment are as follows ...

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Abstract

The invention discloses an eye medicament for treating fungal keratitis, which is the aqueous solution containing 0.1-0.5 wt% of terbinafine hydrochloride and 2.0-4.0 wt% of cyclodextrin.

Description

technical field [0001] The invention relates to an eye medicine, in particular to an eye medicine for treating fungal keratitis. Background technique [0002] Fungal keratitis is a serious blinding eye disease. In recent years, the abuse of antibiotics and glucocorticoids, the wide application of immunosuppressants, and the increase in autoimmune disease cases have led to a sharp increase in the incidence of this eye disease compared with previous years. There is still an increasing trend. my country is a large agricultural country, and young and middle-aged people engaged in industrial and agricultural work are likely to suffer from corneal trauma during labor, which affects production and leads to a decline in personal quality of life. [0003] Although synthetic antifungal drugs have been greatly developed at present, due to the different species of eye infection fungi and other parts of infection fungi, especially the special requirements for eye medications, there is a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/137A61K9/08A61K47/40A61P31/10A61P27/02
Inventor 王香兰
Owner 王香兰
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